Chloroquine-mediated lysosomal dysfunction enhances the anticancer effect of nutrient deprivation

Pharmaceutical Research

Volumn 29, Issue 8, 2012, Pages 2249-2263

  Harhaji Trajkovic, Ljubica ^a   Arsikin, Katarina ^a   Kravic Stevovic, Tamara ^a   Petricevic, Sasa ^b   Tovilovic, Gordana ^a   Pantovic, Aleksandar ^a   Zogovic, Nevena ^a   Ristic, Biljana ^a   Janjetovic, Kristina ^a   Bumbasirevic, Vladimir ^a   Trajkovic, Vladimir ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b Institute of Biomedical Research   (Serbia)

Author keywords

AMPK; Autophagy; Caloric restriction; Cancer; Chloroquine

Indexed keywords

BAFILOMYCIN; CASPASE; CHLOROQUINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA;

ACIDIFICATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CALORIC RESTRICTION; CANCER CELL CULTURE; CANCER INHIBITION; CELL COUNT; CELL MEMBRANE DEPOLARIZATION; CELL RESPIRATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; FIBROSARCOMA; FLOW CYTOMETRY; GENETIC TRANSFECTION; GLIOMA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; LYSOSOME; MELANOMA B16; MELANOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; NUTRIENT DEPRIVATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RNA INTERFERENCE; SARCOMA CELL; TOXICITY; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ANTIMALARIALS; CALORIC RESTRICTION; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CHLOROQUINE; FEMALE; HUMANS; LYSOSOMES; MELANOMA; MICE; MICE, INBRED C57BL; NEOPLASMS; OXIDATIVE STRESS;

EID: 84864447560     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0753-1     Document Type: Article

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