Listeria monocytogenes Infection Causes Metabolic Shifts in Drosophila melanogaster

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Chambers, Moria C ^a   Song, Kyung Han ^a   Schneider, David S ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN; LEVODOPA; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL; TYROSINE; URATE OXIDASE; URIC ACID;

AMINO ACID ANALYSIS; AMINO ACID METABOLISM; ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENERGY METABOLISM; ENZYME DEGRADATION; FATTY ACID OXIDATION; GLYCOLYSIS; HOST PATHOGEN INTERACTION; LISTERIA MONOCYTOGENES; LISTERIOSIS; MELANOGENESIS; METABOLIC DISORDER; METABOLITE; NONHUMAN;

AMINO ACIDS; ANIMALS; DROSOPHILA MELANOGASTER; FATTY ACIDS; GENE EXPRESSION REGULATION; GLYCOGEN; GLYCOLYSIS; IMMUNITY, INNATE; LISTERIA MONOCYTOGENES; LISTERIOSIS; MELANINS; METABOLOMICS; MODELS, BIOLOGICAL; MUTATION; NUCLEOTIDES; OXYGEN; STEM CELLS; TIME FACTORS; TRIGLYCERIDES; URIC ACID;

DROSOPHILA MELANOGASTER; LISTERIA MONOCYTOGENES;

EID: 84871293204     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050679     Document Type: Article

References (20)

1. Dionne MS, Pham LN, Shirasu-Hiza M, Schneider DS, (2006) Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila. Curr Biol 16: 1977-1985.
2. Opota O, Vallet-Gely I, Vincentelli R, Kellenberger C, Iacovache I, et al. (2011) Monalysin, a novel ss-pore-forming toxin from the Drosophila pathogen Pseudomonas entomophila, contributes to host intestinal damage and lethality. PLoS Pathog 7: e1002259.
3. Liehl P, Blight M, Vodovar N, Boccard F, Lemaitre B, (2006) Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model. PLoS Pathog 2: e56.
4. Vodovar N, Vinals M, Liehl P, Basset A, Degrouard J, et al. (2005) Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species. Proc Natl Acad Sci U S A 102: 11414-11419.
5. Becker T, Loch G, Beyer M, Zinke I, Aschenbrenner AC, et al. (2010) FOXO-dependent regulation of innate immune homeostasis. Nature 463: 369-373.
6. Brown AE, Baumbach J, Cook PE, Ligoxygakis P, (2009) Short-term starvation of immune deficient Drosophila improves survival to gram-negative bacterial infections. PLoS One 4: e4490.
7. Ayres JS, Schneider DS, (2009) The role of anorexia in resistance and tolerance to infections in Drosophila. PLoS Biol 7: e1000150.
8. Cotter SC, Simpson SJ, Raubenheimer D, Wilson K, (2011) Macronutrient balance mediates trade-offs between immune function and life history traits. Functional Ecology 25: 186-198.
9. Adamo SA, Bartlett A, Le J, Spencer N, Sullivan K, (2010) Illness-induced anorexia may reduce trade-offs between digestion and immune function. Animal Behaviour 79: 3-10.
10. Cherry S, Kunte A, Wang H, Coyne C, Rawson RB, et al. (2006) COPI activity coupled with fatty acid biosynthesis is required for viral replication. PLoS Pathog 2: e102.
11. Moser TS, D S, Cherry S, (2012) AMP-Activated Kinase Restricts Rift Valley Fever Virus Infection by Inhibiting Fatty Acid Synthesis. PLoS Pathog 8: e1002661.
12. Sun Y, O'Riordan MX, (2010) Branched-chain fatty acids promote Listeria monocytogenes intracellular infection and virulence. Infect Immun 78: 4667-4673.
13. Chambers MC, Lightfield KL, Schneider DS, (2012) How the Fly Balances Its Ability to Combat Different Pathogens. PLoS Pathog (accepted).
14. Ames BN, Cathcart R, Schwiers E, Hochstein P, (1981) Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A 78: 6858-6862.
15. Dow JA, Romero MF, (2010) Drosophila provides rapid modeling of renal development, function, and disease. Am J Physiol Renal Physiol 299: F1237-1244.
16. Wu XW, Lee CC, Muzny DM, Caskey CT, (1989) Urate oxidase: primary structure and evolutionary implications. Proc Natl Acad Sci U S A 86: 9412-9416.
17. Wu XW, Muzny DM, Lee CC, Caskey CT, (1992) Two independent mutational events in the loss of urate oxidase during hominoid evolution. J Mol Evol 34: 78-84.
18. Il'yasova D, Spasojevic I, Wang F, Tolun AA, Base K, et al. (2010) Urinary biomarkers of oxidative status in a clinical model of oxidative assault. Cancer Epidemiol Biomarkers Prev 19: 1506-1510.
19. Nandakumar M, Tan MW, (2008) Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity. PLoS Genet 4: e1000273.
20. Schneider D, Shahabuddin M, (2000) Malaria parasite development in a Drosophila model. Science 288: 2376-2379.