AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation

Nature Medicine

Volumn 18, Issue 2, 2012, Pages 244-251

  Lanner, Johanna T ^a   Georgiou, Dimitra K ^a   Dagnino Acosta, Adan ^a   Ainbinder, Alina ^b   Cheng, Qing ^a   Joshi, Aditya D ^a   Chen, Zanwen ^a   Yarotskyy, Viktor ^b   Oakes, Joshua M ^a   Lee, Chang Seok ^a   Monroe, Tanner O ^a   Santillan, Arturo ^a   Dong, Keke ^a   Goodyear, Laurie ^c   Ismailov, Iskander I ^a   Rodney, George G ^a   Dirksen, Robert T ^b   Hamilton, Susan L ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; CALCIUM ION; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; RYANODINE RECEPTOR 1;

ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL MEMBRANE STEADY POTENTIAL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE PREDISPOSITION; DOSE RESPONSE; ENZYME ACTIVATION; GENE MUTATION; HEAT INJURY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MUSCLE CELL; MUSCLE CONTRACTION; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RHABDOMYOLYSIS; SARCOPLASM; SARCOPLASMIC RETICULUM; SUDDEN DEATH; TEMPERATURE; THERMAL EXPOSURE; TREATMENT DURATION;

ADENOSINE TRIPHOSPHATE; AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CALCIUM; DEATH, SUDDEN; ENZYME ACTIVATION; HEAT STRESS DISORDERS; HOT TEMPERATURE; MALE; MICE; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MUSCLE, SKELETAL; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; RIBONUCLEOTIDES; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM;

MUS;

EID: 84856694906     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2598     Document Type: Article

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