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Volumn 3, Issue 5, 2014, Pages 643-652

Concise review: Optimizing expansion of bone marrow mesenchymal stem/stromal cells for clinical applications

Author keywords

Bioreactor; Expansion; Growth factor; Hypoxia; Mesenchymal stromal stem cell; Progenitor

Indexed keywords

ALKALINE PHOSPHATASE; ASCORBIC ACID; BONE MORPHOGENETIC PROTEIN 2; CHITOSAN; COLLAGEN; DEXAMETHASONE; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; GELATIN; HYDROXYAPATITE; INTERLEUKIN 6; PLATELET DERIVED GROWTH FACTOR BB; POLYETHYLENE TEREPHTHALATE; SOMATOMEDIN C; TRANSFERRIN; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN; WNT3A PROTEIN;

EID: 84899683599     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2013-0196     Document Type: Article
Times cited : (116)

References (106)
  • 1
    • 0026578530 scopus 로고
    • Characterization of cells with osteogenic potential from human marrow
    • Haynesworth SE, Goshima J, GoldbergVM et al. Characterization of cells with osteogenic potential from human marrow. Bone 1992;13: 81-88.
    • (1992) Bone , vol.13 , pp. 81-88
    • Haynesworth, S.E.1    Goshima, J.2    Goldberg, V.M.3
  • 2
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147.
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1    McKay, A.M.2    Beck, S.C.3
  • 3
    • 84860008632 scopus 로고    scopus 로고
    • Differentiation-dependent secretion of proangiogenic factors by mesenchymal stem cells
    • Hoch AI, Binder BY, Genetos DC et al. Differentiation-dependent secretion of proangiogenic factors by mesenchymal stem cells. PLoS One 2012;7:e35579.
    • (2012) PLoS One , vol.7
    • Hoch, A.I.1    Binder, B.Y.2    Genetos, D.C.3
  • 4
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • Dominici M, Le Blanc K, Mueller I et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006;8:315-317.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3
  • 5
    • 0037173116 scopus 로고    scopus 로고
    • Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone
    • Horwitz EM, Gordon PL, Koo WK et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone. Proc Natl Acad Sci USA 2002;99:8932-8937.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8932-8937
    • Horwitz, E.M.1    Gordon, P.L.2    Koo, W.K.3
  • 6
    • 2342482526 scopus 로고    scopus 로고
    • Treatment of severe acute graft-versushost disease with third party haploidentical mesenchymal stemcells
    • Le Blanc K, Rasmusson I, Sundberg B et al. Treatment of severe acute graft-versushost disease with third party haploidentical mesenchymal stemcells. Lancet2004;363:1439-1441.
    • (2004) Lancet , vol.363 , pp. 1439-1441
    • Le Blanc, K.1    Rasmusson, I.2    Sundberg, B.3
  • 7
    • 3042662157 scopus 로고    scopus 로고
    • Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction
    • Chen SL, FangWW, Ye F et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol 2004;94:92-95.
    • (2004) Am J Cardiol , vol.94 , pp. 92-95
    • Chen, S.L.1    Fang, W.W.2    Ye, F.3
  • 8
    • 78649895490 scopus 로고    scopus 로고
    • Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: Results of a phase I study
    • Duijvestein M, Vos AC, Roelofs H et al. Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: Results of a phase I study. Gut 2010;59:1662-1669.
    • (2010) Gut , vol.59 , pp. 1662-1669
    • Duijvestein, M.1    Vos, A.C.2    Roelofs, H.3
  • 10
    • 0028032831 scopus 로고
    • Bone-marrow transplantation in Hurler's syndrome. Effect on skeletal development
    • Field RE, Buchanan JA, Copplemans MG et al. Bone-marrow transplantation in Hurler's syndrome. Effect on skeletal development. J Bone Joint Surg Br 1994;76:975-981.
    • (1994) J Bone Joint Surg Br , vol.76 , pp. 975-981
    • Field, R.E.1    Buchanan, J.A.2    Copplemans, M.G.3
  • 11
    • 0032822268 scopus 로고    scopus 로고
    • Stromal damage as consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients
    • Galotto M, Berisso G, Delfino L et al. Stromal damage as consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients. Exp Hematol 1999;27:1460-1466.
    • (1999) Exp Hematol , vol.27 , pp. 1460-1466
    • Galotto, M.1    Berisso, G.2    Delfino, L.3
  • 12
    • 0017119380 scopus 로고
    • Fibroblast precursors in normal and irradiated mouse hematopoietic organs
    • Friedenstein AJ, Gorskaja JF, Kulagina NN. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol 1976;4:267-274.
    • (1976) Exp Hematol , vol.4 , pp. 267-274
    • Friedenstein, A.J.1    Gorskaja, J.F.2    Kulagina, N.N.3
  • 13
    • 0034047440 scopus 로고    scopus 로고
    • Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy
    • Banfi A, Muraglia A, Dozin B et al. Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy. Exp Hematol 2000;28:707-715.
    • (2000) Exp Hematol , vol.28 , pp. 707-715
    • Banfi, A.1    Muraglia, A.2    Dozin, B.3
  • 14
    • 84957843345 scopus 로고    scopus 로고
    • An in vitro expansion score for tissueengineering applications with human bone marrow-derived mesenchymal stem cells
    • [Epub ahead of print]
    • Bertolo A, Mehr M, Janner-Jametti T et al. An in vitro expansion score for tissueengineering applications with human bone marrow-derived mesenchymal stem cells. J Tissue Eng Regen Med 2013 [Epub ahead of print].
    • (2013) J Tissue Eng Regen Med
    • Bertolo, A.1    Mehr, M.2    Janner-Jametti, T.3
  • 16
    • 0031012465 scopus 로고    scopus 로고
    • Growth kinetics, self-renewal, and the osteogenic potential of purifiedhumanmesenchymal stem cells during extensive subcultivation and following cryopreservation
    • Bruder SP, Jaiswal N, Haynesworth SE. Growth kinetics, self-renewal, and the osteogenic potential of purifiedhumanmesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biochem 1997;64:278-294.
    • (1997) J Cell Biochem , vol.64 , pp. 278-294
    • Bruder, S.P.1    Jaiswal, N.2    Haynesworth, S.E.3
  • 17
    • 0032748173 scopus 로고    scopus 로고
    • Propagation and senescence of human marrow stromal cells in culture: A simple colonyforming assay identifies samples with the greatest potential to propagate and differentiate
    • Digirolamo CM, Stokes D, Colter D et al. Propagation and senescence of human marrow stromal cells in culture: A simple colonyforming assay identifies samples with the greatest potential to propagate and differentiate. Br J Haematol 1999;107:275-281.
    • (1999) Br J Haematol , vol.107 , pp. 275-281
    • Digirolamo, C.M.1    Stokes, D.2    Colter, D.3
  • 18
    • 0034056758 scopus 로고    scopus 로고
    • Clonal mesenchymal progenitors from human bone marrowdifferentiate in vitro according toa hierarchical model
    • Muraglia A, Cancedda R, Quarto R. Clonal mesenchymal progenitors from human bone marrowdifferentiate in vitro according toa hierarchical model. J Cell Sci 2000;113:1161-1166.
    • (2000) J Cell Sci , vol.113 , pp. 1161-1166
    • Muraglia, A.1    Cancedda, R.2    Quarto, R.3
  • 19
    • 0037530021 scopus 로고    scopus 로고
    • Ex vivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2
    • Bianchi G, Banfi A, Mastrogiacomo M et al. Ex vivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2. Exp Cell Res 2003;287:98-105.
    • (2003) Exp Cell Res , vol.287 , pp. 98-105
    • Bianchi, G.1    Banfi, A.2    Mastrogiacomo, M.3
  • 20
    • 0033084169 scopus 로고    scopus 로고
    • Effects of TGFbeta and bFGF on the differentiation of human bone marrow stromal fibroblasts
    • Locklin RM, Oreffo RO, Triffitt JT. Effects of TGFbeta and bFGF on the differentiation of human bone marrow stromal fibroblasts. Cell Biol Int 1999;23:185-194.
    • (1999) Cell Biol Int , vol.23 , pp. 185-194
    • Locklin, R.M.1    Oreffo, R.O.2    Triffitt, J.T.3
  • 21
    • 0030885841 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow
    • Martin I, Muraglia A, Campanile G et al. Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. Endocrinology 1997;138:4456-4462.
    • (1997) Endocrinology , vol.138 , pp. 4456-4462
    • Martin, I.1    Muraglia, A.2    Campanile, G.3
  • 22
    • 0034852846 scopus 로고    scopus 로고
    • Effect of different growth factors on the chondrogenic potential of human bone marrow stromal cells
    • Mastrogiacomo M, Cancedda R, Quarto R. Effect of different growth factors on the chondrogenic potential of human bone marrow stromal cells. Osteoarthritis Cartilage 2001;9 (suppl A):S36-S40.
    • (2001) Osteoarthritis Cartilage , vol.9 , Issue.SUPPL. A
    • Mastrogiacomo, M.1    Cancedda, R.2    Quarto, R.3
  • 23
    • 0030042746 scopus 로고    scopus 로고
    • Effects of fibroblast growth factor-4 (k-FGF) on longterm cultures of human bone marrow cells
    • Quito FL, Beh J, Bashayan O et al. Effects of fibroblast growth factor-4 (k-FGF) on longterm cultures of human bone marrow cells. Blood 1996;87:1282-1291.
    • (1996) Blood , vol.87 , pp. 1282-1291
    • Quito, F.L.1    Beh, J.2    Bashayan, O.3
  • 24
    • 16344377055 scopus 로고    scopus 로고
    • FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrowderived mesenchymal stem cells
    • Solchaga LA, Penick K, Porter JD et al. FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrowderived mesenchymal stem cells. J Cell Physiol 2005;203:398-409.
    • (2005) J Cell Physiol , vol.203 , pp. 398-409
    • Solchaga, L.A.1    Penick, K.2    Porter, J.D.3
  • 25
    • 33745266607 scopus 로고    scopus 로고
    • Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells
    • Sotiropoulou PA, Perez SA, Salagianni M et al. Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells. STEM CELLS 2006;24:462-471.
    • (2006) STEM CELLS , vol.24 , pp. 462-471
    • Sotiropoulou, P.A.1    Perez, S.A.2    Salagianni, M.3
  • 26
    • 0035955303 scopus 로고    scopus 로고
    • Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF
    • Tsutsumi S, Shimazu A, Miyazaki K et al. Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF. Biochem Biophys Res Commun 2001;288:413-419.
    • (2001) Biochem Biophys Res Commun , vol.288 , pp. 413-419
    • Tsutsumi, S.1    Shimazu, A.2    Miyazaki, K.3
  • 27
    • 84859447752 scopus 로고    scopus 로고
    • Hypoxia mediated isolation and expansion enhances the chondrogenic capacity of bone marrow mesenchymal stromal cells
    • Adesida AB, Mulet-Sierra A, Jomha NM. Hypoxia mediated isolation and expansion enhances the chondrogenic capacity of bone marrow mesenchymal stromal cells. Stem Cell Res Ther 2012;3:9.
    • (2012) Stem Cell Res Ther , vol.3 , pp. 9
    • Adesida, A.B.1    Mulet-Sierra, A.2    Jomha, N.M.3
  • 28
    • 79953100662 scopus 로고    scopus 로고
    • Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status
    • Basciano L, Nemos C, Foliguet B et al. Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status. BMC Cell Biol 2011;12:12.
    • (2011) BMC Cell Biol , vol.12 , pp. 12
    • Basciano, L.1    Nemos, C.2    Foliguet, B.3
  • 29
    • 84877056819 scopus 로고    scopus 로고
    • Low oxygen tension maintains multipotency, whereas normoxia increases differentiation of mouse bone marrow stromal cells
    • Berniakovich I, Giorgio M. Low oxygen tension maintains multipotency, whereas normoxia increases differentiation of mouse bone marrow stromal cells. Int J Mol Sci 2013;14: 2119-2134.
    • (2013) Int J Mol Sci , vol.14 , pp. 2119-2134
    • Berniakovich, I.1    Giorgio, M.2
  • 30
    • 84860517151 scopus 로고    scopus 로고
    • Atmospheric oxygen inhibits growth and differentiation of marrow-derived mouse mesenchymal stem cells via a p53-dependent mechanism: Implications for long-term culture expansion
    • Boregowda SV, Krishnappa V, Chambers JW et al. Atmospheric oxygen inhibits growth and differentiation of marrow-derived mouse mesenchymal stem cells via a p53-dependent mechanism: Implications for long-term culture expansion. STEM CELLS 2012;30:975-987.
    • (2012) STEM CELLS , vol.30 , pp. 975-987
    • Boregowda, S.V.1    Krishnappa, V.2    Chambers, J.W.3
  • 31
    • 36249020427 scopus 로고    scopus 로고
    • Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan
    • Fehrer C, Brunauer R, Laschober G et al. Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan. Aging Cell 2007;6:745-757.
    • (2007) Aging Cell , vol.6 , pp. 745-757
    • Fehrer, C.1    Brunauer, R.2    Laschober, G.3
  • 32
    • 34249113091 scopus 로고    scopus 로고
    • Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells
    • Grayson WL, Zhao F, Bunnell B et al. Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells. Biochem Biophys Res Commun 2007;358:948-953.
    • (2007) Biochem Biophys Res Commun , vol.358 , pp. 948-953
    • Grayson, W.L.1    Zhao, F.2    Bunnell, B.3
  • 33
    • 31744442047 scopus 로고    scopus 로고
    • Effects of hypoxia on human mesenchymal stem cell expansion and plasticity in 3D constructs
    • Grayson WL, Zhao F, Izadpanah R et al. Effects of hypoxia on human mesenchymal stem cell expansion and plasticity in 3D constructs. J Cell Physiol 2006;207:331-339.
    • (2006) J Cell Physiol , vol.207 , pp. 331-339
    • Grayson, W.L.1    Zhao, F.2    Izadpanah, R.3
  • 34
    • 83855165785 scopus 로고    scopus 로고
    • Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells
    • Hung SP, Ho JH, Shih YRV et al. Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells. J Orthop Res 2012;30:260-266.
    • (2012) J Orthop Res , vol.30 , pp. 260-266
    • Hung, S.P.1    Ho, J.H.2    Shih, Y.R.V.3
  • 35
    • 0035028655 scopus 로고    scopus 로고
    • Cultivation of rat marrow-derived mesenchymal stem cells in reduced oxygen tension: Effects on in vitro and in vivo osteochondrogenesis
    • Lennon DP, Edmison JM, Caplan AI. Cultivation of rat marrow-derived mesenchymal stem cells in reduced oxygen tension: Effects on in vitro and in vivo osteochondrogenesis. J Cell Physiol 2001;187:345-355.
    • (2001) J Cell Physiol , vol.187 , pp. 345-355
    • Lennon, D.P.1    Edmison, J.M.2    Caplan, A.I.3
  • 36
    • 34147144960 scopus 로고    scopus 로고
    • Transcriptional profiling of human cord blood CD133+ and cultured bone marrow mesenchymal stemcells in response to hypoxia
    • Martin-Rendon E, Hale SJ, Ryan D et al. Transcriptional profiling of human cord blood CD133+ and cultured bone marrow mesenchymal stemcells in response to hypoxia. STEM CELLS 2007;25:1003-1012.
    • (2007) STEM CELLS , vol.25 , pp. 1003-1012
    • Martin-Rendon, E.1    Hale, S.J.2    Ryan, D.3
  • 37
    • 78751535908 scopus 로고    scopus 로고
    • Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through downregulation of E2A-p21 by HIF-TWIST
    • Tsai CC, Chen YJ, Yew TL et al. Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through downregulation of E2A-p21 by HIF-TWIST. Blood 2011;117:459-469.
    • (2011) Blood , vol.117 , pp. 459-469
    • Tsai, C.C.1    Chen, Y.J.2    Yew, T.L.3
  • 38
    • 0042668340 scopus 로고    scopus 로고
    • Adult human bone marrow-derived mesenchymal progenitor cells are capable of adhesionindependent survival and expansion
    • Baksh D, Davies JE, Zandstra PW. Adult human bone marrow-derived mesenchymal progenitor cells are capable of adhesionindependent survival and expansion. Exp Hematol 2003;31:723-732.
    • (2003) Exp Hematol , vol.31 , pp. 723-732
    • Baksh, D.1    Davies, J.E.2    Zandstra, P.W.3
  • 39
    • 25444435416 scopus 로고    scopus 로고
    • Three-dimensional perfusion culture of human bone marrow cells and generation of osteoinductive grafts
    • Braccini A, Wendt D, Jaquiery C et al. Three-dimensional perfusion culture of human bone marrow cells and generation of osteoinductive grafts. STEM CELLS 2005;23:1066-1072.
    • (2005) STEM CELLS , vol.23 , pp. 1066-1072
    • Braccini, A.1    Wendt, D.2    Jaquiery, C.3
  • 40
    • 77955000681 scopus 로고    scopus 로고
    • Dynamic three-dimensional culture methods enhance mesenchymal stem cell properties and increase therapeutic potential
    • Frith JE, Thomson B, Genever PG. Dynamic three-dimensional culture methods enhance mesenchymal stem cell properties and increase therapeutic potential. Tissue Eng Part C Methods 2010;16:735-749.
    • (2010) Tissue Eng Part C Methods , vol.16 , pp. 735-749
    • Frith, J.E.1    Thomson, B.2    Genever, P.G.3
  • 41
    • 84871672621 scopus 로고    scopus 로고
    • The threedimensional collagen scaffold improves the stemness of rat bone marrow mesenchymal stem cells
    • Han S, Zhao Y, Xiao Z et al. The threedimensional collagen scaffold improves the stemness of rat bone marrow mesenchymal stem cells. J Genet Genomics 2012;39:633-641.
    • (2012) J Genet Genomics , vol.39 , pp. 633-641
    • Han, S.1    Zhao, Y.2    Xiao, Z.3
  • 42
    • 30944465395 scopus 로고    scopus 로고
    • Engineering of osteoinductive grafts by isolation and expansion of ovine bone marrow stromal cells directly on 3D ceramic scaffolds
    • Scaglione S, Braccini A, Wendt D et al. Engineering of osteoinductive grafts by isolation and expansion of ovine bone marrow stromal cells directly on 3D ceramic scaffolds. Biotechnol Bioeng 2006;93:181-187.
    • (2006) Biotechnol Bioeng , vol.93 , pp. 181-187
    • Scaglione, S.1    Braccini, A.2    Wendt, D.3
  • 43
    • 34247141436 scopus 로고    scopus 로고
    • Ex vivo expansion of rat bone marrow mesenchymal stromal cells on microcarrier beads in spin culture
    • Yang Y, Rossi FMV, Putnins EE. Ex vivo expansion of rat bone marrow mesenchymal stromal cells on microcarrier beads in spin culture. Biomaterials 2007;28:3110-3120.
    • (2007) Biomaterials , vol.28 , pp. 3110-3120
    • Yang, Y.1    Rossi, F.M.V.2    Putnins, E.E.3
  • 44
    • 33846928754 scopus 로고    scopus 로고
    • Effects of shear stress on 3-D human mesenchymal stem cell construct development in a perfusion bioreactor system: Experiments and hydrodynamic modeling
    • Zhao F, Chella R, Ma T. Effects of shear stress on 3-D human mesenchymal stem cell construct development in a perfusion bioreactor system: Experiments and hydrodynamic modeling. Biotechnol Bioeng 2007;96:584-595.
    • (2007) Biotechnol Bioeng , vol.96 , pp. 584-595
    • Zhao, F.1    Chella, R.2    Ma, T.3
  • 45
    • 28744439514 scopus 로고    scopus 로고
    • Effects of hydroxyapatite in 3-D chitosan-gelatin polymer network on human mesenchymal stem cell construct development
    • Zhao F, Grayson WL, Ma T et al. Effects of hydroxyapatite in 3-D chitosan-gelatin polymer network on human mesenchymal stem cell construct development. Biomaterials 2006;27: 1859-1867.
    • (2006) Biomaterials , vol.27 , pp. 1859-1867
    • Zhao, F.1    Grayson, W.L.2    Ma, T.3
  • 46
    • 62149127776 scopus 로고    scopus 로고
    • Perfusion affects the tissue developmental patterns of human mesenchymal stem cells in 3D scaffolds
    • Zhao F, Grayson WL, MaT et al. Perfusion affects the tissue developmental patterns of human mesenchymal stem cells in 3D scaffolds. J Cell Physiol 2009;219:421-429.
    • (2009) J Cell Physiol , vol.219 , pp. 421-429
    • Zhao, F.1    Grayson, W.L.2    Ma, T.3
  • 47
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965;37: 614-636.
    • (1965) Exp Cell Res , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 48
    • 49349108165 scopus 로고    scopus 로고
    • Effects of plating density and culture time on bone marrow stromal cell characteristics
    • Neuhuber B, Swanger SA, Howard L et al. Effects of plating density and culture time on bone marrow stromal cell characteristics. Exp Hematol 2008;36:1176-1185.
    • (2008) Exp Hematol , vol.36 , pp. 1176-1185
    • Neuhuber, B.1    Swanger, S.A.2    Howard, L.3
  • 49
    • 0034724369 scopus 로고    scopus 로고
    • Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow
    • Colter DC, Class R, DiGirolamo CM et al. Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc Natl Acad Sci USA 2000;97:3213-3218.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3213-3218
    • Colter, D.C.1    Class, R.2    DiGirolamo, C.M.3
  • 50
    • 0036456669 scopus 로고    scopus 로고
    • Expansion of human adult stem cells from bone marrow stroma: Conditions that maximize the yields of early progenitors and evaluate their quality
    • Sekiya I, Larson BL, Smith JR et al. Expansion of human adult stem cells from bone marrow stroma: Conditions that maximize the yields of early progenitors and evaluate their quality. STEM CELLS 2002;20:530-541.
    • (2002) STEM CELLS , vol.20 , pp. 530-541
    • Sekiya, I.1    Larson, B.L.2    Smith, J.R.3
  • 51
    • 57449102937 scopus 로고    scopus 로고
    • Comparison of human placenta-and bone marrow-derived multipotent mesenchymal stem cells
    • Barlow S, Brooke G, Chatterjee K et al. Comparison of human placenta-and bone marrow-derived multipotent mesenchymal stem cells. Stem Cells Dev 2008;17:1095-1107.
    • (2008) Stem Cells Dev , vol.17 , pp. 1095-1107
    • Barlow, S.1    Brooke, G.2    Chatterjee, K.3
  • 52
    • 84855264212 scopus 로고    scopus 로고
    • Multipotent mesenchymal stromal stem cell expansion by plating whole bone marrow at a low cellular density: A more advantageous method for clinical use
    • 2012
    • Mareschi K, Rustichelli D, Calabrese R et al. Multipotent mesenchymal stromal stem cell expansion by plating whole bone marrow at a low cellular density: A more advantageous method for clinical use. Stem Cells Int 2012; 2012:920581.
    • (2012) Stem Cells Int , pp. 920581
    • Mareschi, K.1    Rustichelli, D.2    Calabrese, R.3
  • 53
    • 34548773294 scopus 로고    scopus 로고
    • Gene expression profiling of human mesenchymal stem cells derived from bone marrow during expansion and osteoblast differentiation
    • Kulterer B, Friedl G, Jandrositz A et al. Gene expression profiling of human mesenchymal stem cells derived from bone marrow during expansion and osteoblast differentiation. BMC Genomics 2007;8:70.
    • (2007) BMC Genomics , vol.8 , pp. 70
    • Kulterer, B.1    Friedl, G.2    Jandrositz, A.3
  • 54
    • 84880573708 scopus 로고    scopus 로고
    • Assessing the potential of colony morphology for dissecting the CFU-F population from human bone marrow stromal cells
    • GothardD, DawsonJI, OreffoRO. Assessing the potential of colony morphology for dissecting the CFU-F population from human bone marrow stromal cells. Cell Tissue Res 2013;352:237-247.
    • (2013) Cell Tissue Res , vol.352 , pp. 237-247
    • Gothard, D.1    Dawson, J.I.2    Oreffo, R.O.3
  • 55
    • 84858661300 scopus 로고    scopus 로고
    • Population dynamics of mesenchymal stromal cells during culture expansion
    • Schellenberg A, Stiehl T, Horn P et al. Population dynamics of mesenchymal stromal cells during culture expansion. Cytotherapy 2012;14: 401-411.
    • (2012) Cytotherapy , vol.14 , pp. 401-411
    • Schellenberg, A.1    Stiehl, T.2    Horn, P.3
  • 56
    • 0026722875 scopus 로고
    • Bone marrow stromal colony formation requires stimulation by haemopoietic cells
    • Friedenstein AJ, Latzinik NV, Gorskaya YuF et al. Bone marrow stromal colony formation requires stimulation by haemopoietic cells. Bone Miner 1992;18:199-213.
    • (1992) Bone Miner , vol.18 , pp. 199-213
    • Friedenstein, A.J.1    Latzinik, N.V.2    Gorskaya Yu, F.3
  • 57
    • 84880628630 scopus 로고    scopus 로고
    • Tracking of replicative senescence in mesenchymal stem cells by colony-forming unit frequency
    • Schellenberg A, Hemeda H, Wagner W. Tracking of replicative senescence in mesenchymal stem cells by colony-forming unit frequency. Methods Mol Biol 2013;976:143-154.
    • (2013) Methods Mol Biol , vol.976 , pp. 143-154
    • Schellenberg, A.1    Hemeda, H.2    Wagner, W.3
  • 58
    • 34547185045 scopus 로고    scopus 로고
    • The osteogenicity of implanted engineered bone constructs is related to the density of clonogenic bone marrow stromal cells
    • Braccini A, Wendt D, Farhadi J et al. The osteogenicity of implanted engineered bone constructs is related to the density of clonogenic bone marrow stromal cells. J Tissue Eng Regen Med 2007;1:60-65.
    • (2007) J Tissue Eng Regen Med , vol.1 , pp. 60-65
    • Braccini, A.1    Wendt, D.2    Farhadi, J.3
  • 59
    • 0031090621 scopus 로고    scopus 로고
    • Human mesenchymal stem cells respond to fibroblast growth factors
    • vandenBosC, MoscaJD, Winkles Jetal. Human mesenchymal stem cells respond to fibroblast growth factors. Hum Cell 1997;10:45-50.
    • (1997) Hum Cell , vol.10 , pp. 45-50
    • vandenBos, C.1    Mosca, J.D.2    Winkles, J.3
  • 60
    • 0024518507 scopus 로고
    • Cultured bovine bone cells synthesize basic fibroblast growth factor and store it in their extracellular matrix
    • Globus RK, Plouet J, Gospodarowicz D. Cultured bovine bone cells synthesize basic fibroblast growth factor and store it in their extracellular matrix. Endocrinology 1989;124:1539-1547.
    • (1989) Endocrinology , vol.124 , pp. 1539-1547
    • Globus, R.K.1    Plouet, J.2    Gospodarowicz, D.3
  • 61
    • 0023037767 scopus 로고
    • Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose
    • Hauschka PV, MavrakosAE, IafratiMDet al. Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose. J Biol Chem 1986;261:12665-12674.
    • (1986) J Biol Chem , vol.261 , pp. 12665-12674
    • Hauschka, P.V.1    Mavrakos, A.E.2    Iafrati, M.D.3
  • 62
    • 78649859752 scopus 로고    scopus 로고
    • Influence of shear stress in perfusion bioreactor cultures for the development of three-dimensional bone tissue constructs: A review
    • McCoy RJ, O'Brien FJ. Influence of shear stress in perfusion bioreactor cultures for the development of three-dimensional bone tissue constructs: A review. Tissue Eng Part B Rev 2010;16:587-601.
    • (2010) Tissue Eng Part B Rev , vol.16 , pp. 587-601
    • McCoy, R.J.1    O'Brien, F.J.2
  • 63
    • 0034490461 scopus 로고    scopus 로고
    • Oxygen tension influences the differentiation, maturation and apoptosis of human megakaryocytes
    • Mostafa SS, Miller WM, Papoutsakis ET. Oxygen tension influences the differentiation, maturation and apoptosis of human megakaryocytes. Br J Haematol 2000;111:879-889.
    • (2000) Br J Haematol , vol.111 , pp. 879-889
    • Mostafa, S.S.1    Miller, W.M.2    Papoutsakis, E.T.3
  • 64
    • 84862889994 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c
    • DiMaggioN, MehrkensA, Papadimitropoulos A et al. Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c. STEM CELLS 2012;30: 1455-1464.
    • (2012) STEM CELLS , vol.30 , pp. 1455-1464
    • DiMaggio, N.1    Mehrkens, A.2    Papadimitropoulos, A.3
  • 65
    • 78449232489 scopus 로고    scopus 로고
    • Toward modeling the bone marrow niche using scaffold-based 3D culture systems
    • Di Maggio N, Piccinini E, JaworskiMet al. Toward modeling the bone marrow niche using scaffold-based 3D culture systems. Biomaterials 2011;32:321-329.
    • (2011) Biomaterials , vol.32 , pp. 321-329
    • Di Maggio, N.1    Piccinini, E.2    Jaworski, M.3
  • 66
    • 78049383613 scopus 로고    scopus 로고
    • Presentation counts: Microenvironmental regulation of stem cells by biophysical and material cues
    • Keung AJ, Kumar S, Schaffer DV. Presentation counts: Microenvironmental regulation of stem cells by biophysical and material cues. Annu Rev Cell Dev Biol 2010;26:533-556.
    • (2010) Annu Rev Cell Dev Biol , vol.26 , pp. 533-556
    • Keung, A.J.1    Kumar, S.2    Schaffer, D.V.3
  • 67
    • 77953158654 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF) treatment on multipotential stromal cells (MSCs). Possible enhancement of therapeutic potential of MSC
    • 2010
    • Tamama K, Kawasaki H, Wells A. Epidermal growth factor (EGF) treatment on multipotential stromal cells (MSCs). Possible enhancement of therapeutic potential of MSC. J Biomed Biotechnol 2010;2010:795385.
    • (2010) J Biomed Biotechnol , pp. 795385
    • Tamama, K.1    Kawasaki, H.2    Wells, A.3
  • 68
    • 20344363684 scopus 로고    scopus 로고
    • Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation
    • Kratchmarova I, Blagoev B, Haack-Sorensen M et al. Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation. Science 2005;308:1472-1477.
    • (2005) Science , vol.308 , pp. 1472-1477
    • Kratchmarova, I.1    Blagoev, B.2    Haack-Sorensen, M.3
  • 69
    • 33744979059 scopus 로고    scopus 로고
    • Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells
    • Tamama K, Fan VH, Griffith LG et al. Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells. STEM CELLS 2006;24:686-695.
    • (2006) STEM CELLS , vol.24 , pp. 686-695
    • Tamama, K.1    Fan, V.H.2    Griffith, L.G.3
  • 70
    • 84873038745 scopus 로고    scopus 로고
    • Effects of medium supplements on proliferation, differentiation potential, and in vitro expansion of mesenchymal stem cells
    • Gharibi B, Hughes FJ. Effects of medium supplements on proliferation, differentiation potential, and in vitro expansion of mesenchymal stem cells. STEM CELLS TRANSLATIONAL MEDICINE 2012;1:771-782.
    • (2012) STEM CELLS TRANSLATIONAL MEDICINE , vol.1 , pp. 771-782
    • Gharibi, B.1    Hughes, F.J.2
  • 71
    • 0029116176 scopus 로고
    • A chemically defined medium supports in vitro proliferation and maintains the osteochondral potential of rat marrow-derived mesenchymal stem cells
    • Lennon DP, Haynesworth SE, Young RG et al. A chemically defined medium supports in vitro proliferation and maintains the osteochondral potential of rat marrow-derived mesenchymal stem cells. Exp Cell Res 1995;219:211-222.
    • (1995) Exp Cell Res , vol.219 , pp. 211-222
    • Lennon, D.P.1    Haynesworth, S.E.2    Young, R.G.3
  • 72
    • 0025845372 scopus 로고
    • Initiation and progression of mineralization of bone nodules formed in vitro: The role of alkaline phosphatase and organic phosphate
    • Bellows CG, Aubin JE, Heersche JN. Initiation and progression of mineralization of bone nodules formed in vitro: The role of alkaline phosphatase and organic phosphate. Bone Miner 1991;14:27-40.
    • (1991) Bone Miner , vol.14 , pp. 27-40
    • Bellows, C.G.1    Aubin, J.E.2    Heersche, J.N.3
  • 73
    • 0033173019 scopus 로고    scopus 로고
    • Systemic injection of FGF-2 stimulates endocortical bone modelling in SAMP6, a murine model of low turnover osteopenia
    • Nagai H, Tsukuda R, YamasakiHet al. Systemic injection of FGF-2 stimulates endocortical bone modelling in SAMP6, a murine model of low turnover osteopenia. J Vet Med Sci 1999; 61:869-875.
    • (1999) J Vet Med Sci , vol.61 , pp. 869-875
    • Nagai, H.1    Tsukuda, R.2    Yamasaki, H.3
  • 74
    • 0005000539 scopus 로고
    • Critical effect of oxygen tension on rate of growth of animal cells in continuous suspended culture
    • Cooper PD, Burt AM, Wilson JN. Critical effect of oxygen tension on rate of growth of animal cells in continuous suspended culture. Nature 1958;182:1508-1509.
    • (1958) Nature , vol.182 , pp. 1508-1509
    • Cooper, P.D.1    Burt, A.M.2    Wilson, J.N.3
  • 75
    • 0026501993 scopus 로고
    • The pericyte as a possible osteoblast progenitor cell
    • Brighton CT, Lorich DG, Kupcha R et al. The pericyte as a possible osteoblast progenitor cell. Clin Orthop Relat Res 1992;275287-299.
    • (1992) Clin Orthop Relat Res , vol.275 , pp. 287-299
    • Brighton, C.T.1    Lorich, D.G.2    Kupcha, R.3
  • 77
    • 0018238715 scopus 로고
    • The effect of oxygen tension on haemopoietic and fibroblast cell proliferation in vitro
    • Bradley TR, Hodgson GS, Rosendaal M. The effect of oxygen tension on haemopoietic and fibroblast cell proliferation in vitro. J Cell Physiol 1978;97(suppl 1):517-522.
    • (1978) J Cell Physiol , vol.97 , Issue.SUPPL. 1 , pp. 517-522
    • Bradley, T.R.1    Hodgson, G.S.2    Rosendaal, M.3
  • 78
    • 0022397536 scopus 로고
    • Bone marrow circulation after osteotomy. Blood flow, pO2, pCO2, and pressure studied in dogs
    • Kofoed H, Sjøntoft E, Siemssen SO et al. Bone marrow circulation after osteotomy. Blood flow, pO2, pCO2, and pressure studied in dogs. Acta Orthop Scand 1985;56:400-403.
    • (1985) Acta Orthop Scand , vol.56 , pp. 400-403
    • Kofoed, H.1    Sjøntoft, E.2    Siemssen, S.O.3
  • 79
    • 0001766243 scopus 로고
    • Bone marrow gas tensions, bone marrow blood flow, and erythropoiesis in man
    • Grant JL, Smith B. Bone marrow gas tensions, bone marrow blood flow, and erythropoiesis in man. Ann Intern Med 1963;58:801-809.
    • (1963) Ann Intern Med , vol.58 , pp. 801-809
    • Grant, J.L.1    Smith, B.2
  • 80
    • 0018871893 scopus 로고
    • Oxygen toxicity
    • Frank L, Massaro D. Oxygen toxicity. AmJ Med 1980;69:117-126.
    • (1980) AmJ Med , vol.69 , pp. 117-126
    • Frank, L.1    Massaro, D.2
  • 81
    • 84879840462 scopus 로고    scopus 로고
    • Culture of human mesenchymal stem cells on microcarriers in a 5 l stirred-tank bioreactor
    • Rafiq QA, Brosnan KM, Coopman K et al. Culture of human mesenchymal stem cells on microcarriers in a 5 l stirred-tank bioreactor. Biotechnol Lett 2013;35:1233-1245.
    • (2013) Biotechnol Lett , vol.35 , pp. 1233-1245
    • Rafiq, Q.A.1    Brosnan, K.M.2    Coopman, K.3
  • 82
    • 0035671158 scopus 로고    scopus 로고
    • The design of scaffolds for use in tissue engineering. Part I. Traditional factors
    • Yang S, Leong KF, Du Z et al. The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Eng 2001;7:679-689.
    • (2001) Tissue Eng , vol.7 , pp. 679-689
    • Yang, S.1    Leong, K.F.2    Du, Z.3
  • 83
    • 33749188522 scopus 로고    scopus 로고
    • Bioreactor expansion of human adult bone marrow-derived mesenchymal stem cells
    • Chen X, Xu H, Wan C et al. Bioreactor expansion of human adult bone marrow-derived mesenchymal stem cells. STEM CELLS 2006;24: 2052-2059.
    • (2006) STEM CELLS , vol.24 , pp. 2052-2059
    • Chen, X.1    Xu, H.2    Wan, C.3
  • 84
    • 0344690099 scopus 로고    scopus 로고
    • Experimental and theoretical considerations on oxygen supply for animal cell growth in fixed-bed reactors
    • Fassnacht D, Pörtner R. Experimental and theoretical considerations on oxygen supply for animal cell growth in fixed-bed reactors. J Biotechnol 1999;72:169-184.
    • (1999) J Biotechnol , vol.72 , pp. 169-184
    • Fassnacht, D.1    Pörtner, R.2
  • 85
    • 1642563967 scopus 로고    scopus 로고
    • The role of bioreactors in tissue engineering
    • Martin I, Wendt D, Heberer M. The role of bioreactors in tissue engineering. Trends Biotechnol 2004;22:80-86.
    • (2004) Trends Biotechnol , vol.22 , pp. 80-86
    • Martin, I.1    Wendt, D.2    Heberer, M.3
  • 86
    • 79960621058 scopus 로고    scopus 로고
    • Bioreactor systems for bone tissue engineering
    • Rauh J, Milan F, Günther KP et al. Bioreactor systems for bone tissue engineering. Tissue Eng Part B Rev 2011;17:263-280.
    • (2011) Tissue Eng Part B Rev , vol.17 , pp. 263-280
    • Rauh, J.1    Milan, F.2    Günther, K.P.3
  • 87
    • 84874000672 scopus 로고    scopus 로고
    • Comparative study of in vitro expansion of bone marrow-derived mesenchymal stem cells
    • Peter S, Scutt AM, Wright PC et al. Comparative study of in vitro expansion of bone marrow-derived mesenchymal stem cells. Biotechnol Lett 2013;35:463-469.
    • (2013) Biotechnol Lett , vol.35 , pp. 463-469
    • Peter, S.1    Scutt, A.M.2    Wright, P.C.3
  • 88
    • 0034609615 scopus 로고    scopus 로고
    • Engineering three-dimensional bone tissue in vitro using biodegradable scaffolds: Investigating initial cell-seeding density and culture period
    • Holy CE, Shoichet MS, Davies JE. Engineering three-dimensional bone tissue in vitro using biodegradable scaffolds: Investigating initial cell-seeding density and culture period. J Biomed Mater Res 2000;51:376-382.
    • (2000) J Biomed Mater Res , vol.51 , pp. 376-382
    • Holy, C.E.1    Shoichet, M.S.2    Davies, J.E.3
  • 89
    • 0034798881 scopus 로고    scopus 로고
    • Effects of filtration seeding on cell density, spatial distribution, and proliferation in nonwoven fibrous matrices
    • Li Y, Ma T, Kniss DA et al. Effects of filtration seeding on cell density, spatial distribution, and proliferation in nonwoven fibrous matrices. Biotechnol Prog 2001;17:935-944.
    • (2001) Biotechnol Prog , vol.17 , pp. 935-944
    • Li, Y.1    Ma, T.2    Kniss, D.A.3
  • 90
    • 84899703775 scopus 로고    scopus 로고
    • Ceramic identity contributes to mechanical properties and osteoblast behavior on macroporous composite scaffolds
    • Morales-Hernandez DG, Genetos DC, Murphy KC et al. Ceramic identity contributes to mechanical properties and osteoblast behavior on macroporous composite scaffolds. J Functional Biomater 2012;3:382-397.
    • (2012) J Functional Biomater , vol.3 , pp. 382-397
    • Morales-Hernandez, D.G.1    Genetos, D.C.2    Murphy, K.C.3
  • 91
    • 0141596127 scopus 로고    scopus 로고
    • Oscillating perfusion of cell suspensions through three-dimensional scaffolds enhances cell seeding efficiency and uniformity
    • Wendt D, Marsano A, Jakob M et al. Oscillating perfusion of cell suspensions through three-dimensional scaffolds enhances cell seeding efficiency and uniformity. Biotechnol Bioeng 2003;84:205-214.
    • (2003) Biotechnol Bioeng , vol.84 , pp. 205-214
    • Wendt, D.1    Marsano, A.2    Jakob, M.3
  • 93
    • 0345598939 scopus 로고    scopus 로고
    • Mineralized matrix deposition by marrow stromal osteoblasts in 3D perfusion culture increases with increasing fluid shear forces
    • Sikavitsas VI, Bancroft GN, Holtorf HL et al. Mineralized matrix deposition by marrow stromal osteoblasts in 3D perfusion culture increases with increasing fluid shear forces. Proc Natl Acad Sci USA 2003;100:14683-14688.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14683-14688
    • Sikavitsas, V.I.1    Bancroft, G.N.2    Holtorf, H.L.3
  • 94
    • 80053146421 scopus 로고    scopus 로고
    • Chondrogenic differentiation of human bone marrow mesenchymal stem cells in chitosan-based scaffolds using a flow-perfusion bioreactor
    • Alves da Silva ML, Martins A, Costa-Pinto AR et al. Chondrogenic differentiation of human bone marrow mesenchymal stem cells in chitosan-based scaffolds using a flow-perfusion bioreactor. J Tissue Eng Regen Med 2011;5:722-732.
    • (2011) J Tissue Eng Regen Med , vol.5 , pp. 722-732
    • da Silva Alves, M.L.1    Martins, A.2    Costa-Pinto, A.R.3
  • 95
    • 84858668486 scopus 로고    scopus 로고
    • Singleplatformquality control assay to quantifymultipotential stromal cells inbonemarrowaspiratesprior to bulk manufacture or direct therapeutic use
    • Cuthbert R, Boxall SA, Tan HB et al. Singleplatformquality control assay to quantifymultipotential stromal cells inbonemarrowaspiratesprior to bulk manufacture or direct therapeutic use. Cytotherapy 2012;14:431-440.
    • (2012) Cytotherapy , vol.14 , pp. 431-440
    • Cuthbert, R.1    Boxall, S.A.2    Tan, H.B.3
  • 96
    • 77955864457 scopus 로고    scopus 로고
    • Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines
    • Tsai CC, Chen CL, LiuHCet al. Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines. J Biomed Sci 2010;17:64.
    • (2010) J Biomed Sci , vol.17 , pp. 64
    • Tsai, C.C.1    Chen, C.L.2    Liu, H.C.3
  • 97
    • 0348015840 scopus 로고    scopus 로고
    • Flow perfusion culture of marrow stromal osteoblasts in titanium fiber mesh
    • van den Dolder J, Bancroft GN, Sikavitsas VI et al. Flow perfusion culture of marrow stromal osteoblasts in titanium fiber mesh. J Biomed Mater Res A 2003;64:235-241.
    • (2003) J Biomed Mater Res A , vol.64 , pp. 235-241
    • van den Dolder, J.1    Bancroft, G.N.2    Sikavitsas, V.I.3
  • 98
    • 38749098732 scopus 로고    scopus 로고
    • Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts
    • Chen XD, Dusevich V, Feng JQ et al. Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts. J Bone Miner Res 2007;22:1943-1956.
    • (2007) J Bone Miner Res , vol.22 , pp. 1943-1956
    • Chen, X.D.1    Dusevich, V.2    Feng, J.Q.3
  • 99
    • 79954424469 scopus 로고    scopus 로고
    • Design of experiments approach to engineer cell-secreted matrices for directing osteogenic differentiation
    • Decaris ML, Leach JK. Design of experiments approach to engineer cell-secreted matrices for directing osteogenic differentiation. Ann Biomed Eng 2011;39:1174-1185.
    • (2011) Ann Biomed Eng , vol.39 , pp. 1174-1185
    • Decaris, M.L.1    Leach, J.K.2
  • 100
    • 33644907150 scopus 로고    scopus 로고
    • In vitro localization of bone growth factors in constructs of biodegradable scaffolds seeded with marrow stromal cells and cultured in a flow perfusion bioreactor
    • Gomes ME, Bossano CM, Johnston CM et al. In vitro localization of bone growth factors in constructs of biodegradable scaffolds seeded with marrow stromal cells and cultured in a flow perfusion bioreactor. Tissue Eng 2006;12:177-188.
    • (2006) Tissue Eng , vol.12 , pp. 177-188
    • Gomes, M.E.1    Bossano, C.M.2    Johnston, C.M.3
  • 101
    • 33847713357 scopus 로고    scopus 로고
    • Hypoxia affects mesenchymal stromal cell osteogenic differentiation and angiogenic factor expression
    • Potier E, Ferreira E, Andriamanalijaona R et al. Hypoxia affects mesenchymal stromal cell osteogenic differentiation and angiogenic factor expression. Bone 2007;40:1078-1087.
    • (2007) Bone , vol.40 , pp. 1078-1087
    • Potier, E.1    Ferreira, E.2    Andriamanalijaona, R.3
  • 102
    • 0033589363 scopus 로고    scopus 로고
    • Analysisofcellgrowth kinetics and substrate diffusion in a polymer scaffold
    • GalbanCJ, LockeBR. Analysisofcellgrowth kinetics and substrate diffusion in a polymer scaffold. Biotechnol Bioeng 1999;65:121-132.
    • (1999) Biotechnol Bioeng , vol.65 , pp. 121-132
    • Galban, C.J.1    Locke, B.R.2
  • 103
    • 1542510685 scopus 로고    scopus 로고
    • Oxygen gradients in tissue-engineered PEGT/PBT cartilaginous constructs: Measurement and modeling
    • Malda J, Rouwkema J, Martens DE et al. Oxygen gradients in tissue-engineered PEGT/PBT cartilaginous constructs: Measurement and modeling. Biotechnol Bioeng 2004;86:9-18.
    • (2004) Biotechnol Bioeng , vol.86 , pp. 9-18
    • Malda, J.1    Rouwkema, J.2    Martens, D.E.3
  • 104
    • 84884352926 scopus 로고    scopus 로고
    • A liposome-based ion release impedance sensor for biological detection
    • Damhorst GL, Smith CE, SalmEMet al. A liposome-based ion release impedance sensor for biological detection. Biomed Microdevices 2013;15:895-905.
    • (2013) Biomed Microdevices , vol.15 , pp. 895-905
    • Damhorst, G.L.1    Smith, C.E.2    Salm, E.M.3
  • 105
    • 79953664916 scopus 로고    scopus 로고
    • Noninvasive multimodal evaluation of bioengineered cartilage constructs combining time-resolved fluorescence and ultrasound imaging
    • Fite BZ, Decaris M, Sun Y et al. Noninvasive multimodal evaluation of bioengineered cartilage constructs combining time-resolved fluorescence and ultrasound imaging. Tissue Eng Part C Methods 2011;17:495-504.
    • (2011) Tissue Eng Part C Methods , vol.17 , pp. 495-504
    • Fite, B.Z.1    Decaris, M.2    Sun, Y.3
  • 106
    • 84867098666 scopus 로고    scopus 로고
    • Online monitoring of oxygen as a non-destructive method to quantify cells in engineered 3D tissue constructs
    • Santoro R, Krause C, Martin I et al. Online monitoring of oxygen as a non-destructive method to quantify cells in engineered 3D tissue constructs. J Tissue Eng Regen Med 2011; 6:696-701.
    • (2011) J Tissue Eng Regen Med , vol.6 , pp. 696-701
    • Santoro, R.1    Krause, C.2    Martin, I.3


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