The osteogenicity of implanted engineered bone constructs is related to the density of clonogenic bone marrow stromal cells

Journal of Tissue Engineering and Regenerative Medicine

Volumn 1, Issue 1, 2007, Pages 60-65

  Braccini, Alessandra ^a   Wendt, David ^a   Farhadi, Jian ^a   Schaeren, Stefan ^a   Heberer, Michael ^a   Martin, Ivan ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Bioreactor; Bone tissue engineering; CFU f; Mesenchymal stem cells

Indexed keywords

BIOREACTORS; BONE; CELL ENGINEERING; MAMMALS; SCAFFOLDS (BIOLOGY); STEM CELLS;

BIOREACTOR; BONE MARROW STROMAL CELLS; BONE SUBSTITUTES; BONE TISSUE ENGINEERING; BONE-CONSTRUCTS; CFU-F; CLONOGENICS; MESENCHYMAL STEM CELL; OSTEOGENIC; OSTEOGENICITY;

CELL CULTURE;

BIOMATERIAL;

ADULT; AGED; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; HUMAN; MIDDLE AGED; PHENOTYPE; STROMA CELL;

ADULT; AGED; BIOCOMPATIBLE MATERIALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; HUMANS; MIDDLE AGED; OSTEOGENESIS; PHENOTYPE; STROMAL CELLS;

EID: 34547185045     PISSN: 19326254     EISSN: 19327005     Source Type: Journal    
DOI: 10.1002/term.11     Document Type: Article

References (19)

1. Baksh D, Davies JE, Zandstra PW. 2005; Soluble factor crosstalk between human bone marrow-derived hematopoietic and mesenchymal cells enhances in vitro CFU-F and CFU-O growth and reveals heterogeneity in the mesenchymal progenitor cell compartment. Blood 106: 3012-3019.
2. Boiret N, Rapatel C, Veyrat-Masson R, et al. 2005; Characterization of nonexpanded mesenchymal progenitor cells from normal adult human bone marrow. Exp Hematol 33: 219-225.
3. Braccini A, Wendt D, Jaquiery C, et al. 2005; Three-dimensional perfusion culture of human bone marrow cells and generation of osteoinductive grafts. Stem Cells 23: 1066-1072.
4. D'Ippolito G, Schiller PC, Ricordi C, Roos BA, Howard GA. 1999; Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow. J Bone Miner Res 14: 1115-1122.
5. Frank O, Heim M, Jakob M, et al. 2002; Real-time quantitative RT-PCR analysis of human bone marrow stromal cells during osteogenic differentiation in vitro. J Cell Biochem 85: 737-746.
6. + fraction of adult human bone marrow contains the osteogenic precursors. Blood 84: 4164-4173.
7. Haynesworth SE, Goshima J, Goldberg VM, Caplan AI. 1992; Characterization of cells with osteogenic potential from human marrow. Bone 13: 81-88.
8. Jaquiery C, Schaeren S, Farhadi J, et al. 2005; In vitro osteogenic differentiation and in vivo bone-forming capacity of human isogenic jaw periosteal cells and bone marrow stromal cells. Ann Surg 242: 859-867 [discussion].
9. Jones EA, Kinsey SE, English A, et al. 2002; Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. Arthrit Rheum 46: 3349-3360.
10. Joyner CJ, Bennett A, Triffitt JT. 1997; Identification and enrichment of human osteoprogenitor cells by using differentiation stagespecific monoclonal antibodies. Bone 21: 1-6.
11. Kon E, Muraglia A, Corsi A, et al. 2000; Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical-size defects of sheep long bones. J Biomed Mater Res 49: 328-337.
12. Martin I, Muraglia A, Campanile G, Cancedda R, Quarto R. 1997; Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. Endocrinology 138: 4456-4462.
13. Mendes SC, Tibbe JM, Veenhof M, et al. 2004; Relation between in vitro and in vivo osteogenic potential of cultured human bone marrow stromal cells. J Mater Sci Mater Med 15: 1123-1128.
14. Muraglia A, Martin I, Cancedda R, Quarto R. 1998; A nude mouse model for human bone formation in unloaded conditions. Bone 22: S 131-134.
15. Quarto R, Mastrogiacomo M, Cancedda R, et al. 2001; Repair of large bone defects with the use of autologous bonemarrowstromal cells. N Engl JMed 344: 385-386.
16. Silber JS, Anderson DG, Daffner SD, et al. 2003; Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion. Spine 28: 134-139.
17. Simmons PJ, Torok-Storb B. 1991; Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood 78: 55-62.
18. Stewart K, Monk P, Walsh S, et al. 2003; STRO-1, HOP-26 (CD63), CD49a and SB-10 (CD166) as markers of primitive humanmarrow stromal cells and their more differentiated progeny: a comparative investigation in vitro. Cell Tissue Res 313: 281-290.
19. Wendt D, Marsano A, Jakob M, Heberer M, Martin I. 2003; Oscillating perfusion of cell suspensions through threedimensional scaffolds enhances cell seeding efficiency and uniformity. Biotechnol Bioeng 84: 205-214.