Effects of shear stress on 3-D human mesenchymal stem cell construct development in a perfusion bioreactor system: Experiments and hydrodynamic modeling

Biotechnology and Bioengineering

Volumn 96, Issue 3, 2007, Pages 584-595

  Zhao, Feng ^a   Chella, Ravindran ^a   Ma, Teng ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

Author keywords

Flow rate; Human mesenchymal stem cells; Hydrodynamic modeling; Lattice boltzmann method; Perfusion bioreactor; Shear stress

Indexed keywords

CELL CULTURE; COMPUTER SIMULATION; GROWTH KINETICS; MATHEMATICAL TECHNIQUES; METABOLISM; SHEAR STRESS;

FIBRONECTIN; HUMAN MESENCHYMAL STEM CELLS; HYDRODYNAMIC MODELING; LATTICE-BOLTZMANN METHOD; OXYGEN TRANSPORT; PERFUSION BIOREACTOR;

BIOREACTORS;

ALKALINE PHOSPHATASE; CALCIUM; FIBRONECTIN; HEAT SHOCK PROTEIN 47; POLYETHYLENE TEREPHTHALATE;

ARTICLE; BIOREACTOR; CELL DIFFERENTIATION; CELL GROWTH; CELL METABOLISM; CELL PROLIFERATION; COLONY FORMING UNIT F; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FLOW RATE; HUMAN; HUMAN CELL; HYDRODYNAMICS; MATHEMATICAL MODEL; MESENCHYMAL STEM CELL; OXYGEN TRANSPORT; PERFUSION; PROTEIN EXPRESSION; PROTEIN SECRETION; SHEAR STRESS; UPREGULATION;

ADULT; ANTIGENS, DIFFERENTIATION; BIOLOGICAL TRANSPORT; BIOREACTORS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; HUMANS; MALE; MESENCHYMAL STEM CELLS; MIDDLE AGED; MODELS, BIOLOGICAL; OSTEOBLASTS; OXYGEN; RHEOLOGY; SHEAR STRENGTH; STRESS, MECHANICAL; TIME FACTORS;

EID: 33846928754     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21184     Document Type: Article

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