Gene expression profiling of human mesenchymal stem cells derived from bone marrow during expansion and osteoblast differentiation

BMC Genomics

Volumn 8, Issue , 2007, Pages

  Kulterer, Birgit ^a   Friedl, Gerald ^b   Jandrositz, Anita ^c   Sanchez Cabo, Fatima ^a   Prokesch, Andreas ^a   Paar, Christine ^a   Scheideler, Marcel ^a   Windhager, Reinhard ^b   Preisegger, Karl Heinz ^c   Trajanoski, Zlatko ^a  

^a GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c EccoCell Biotechnology Inc   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; BETA CRYSTALLIN; BONE MORPHOGENETIC PROTEIN; GLYCOPROTEIN; INHIBITOR OF DIFFERENTIATION 4; NEUROTENSIN RECEPTOR; OLIGONUCLEOTIDE; SMAD PROTEIN; SORTILIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL EXPANSION; CELL POPULATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; HUMAN; HUMAN CELL; LONG TERM EXPOSURE; MALE; MESENCHYMAL STEM CELL; MICROARRAY ANALYSIS; MINERALIZATION; NUCLEOTIDE SEQUENCE; OSTEOBLAST; SIGNAL TRANSDUCTION;

EID: 34548773294     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-8-70     Document Type: Article

References (58)

1. Haynesworth SE Goshima J Goldberg VM Caplan AI: Characterization of cells with osteogenic potential from human marrow. Bone 1992, 13:81-88. 10.1016/8756-3282(92)90364-3 1581112
2. Bruder SP Jaiswal N Haynesworth SE: Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biochem 1997, 64:278-294. 10.1002/ (SICI)1097-4644(199702)64:2<278::AID-JCB11>3.0.CO;2-F 9027588
3. Pittenger MF Martin BJ: Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 2004, 95:9-20. 10.1161/ 01.RES.0000135902.99383.6f 15242981
4. Xu W Zhang X Qian H Zhu W Sun X Hu J Zhou H Chen Y: Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro. Exp Biol Med (Maywood) 2004, 229:623-631. 15229356
5. Hofstetter CP Schwarz EJ Hess D Widenfalk J El M Prockop DJ Olson L: Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc Natl Acad Sci U S A 2002, 99:2199-2204. 122342 11854516 10.1073/pnas.042678299
6. Sanchez-Ramos J Song S Cardozo-Pelaez F Hazzi C Stedeford T Willing A Freeman TB Saporta S Janssen W Patel N Cooper DR Sanberg PR: Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 2000, 164:247-256. 10.1006/exnr.2000.7389 10915564
7. Hayflick L: Antecedents of cell aging research. Exp Gerontol 1989, 24:355-365. 10.1016/0531-5565(89)90043-0 2698813
8. Shake JG Gruber PJ Baumgartner WA Senechal G Meyers J Redmond JM Pittenger MF Martin BJ: Mesenchymal stem cell implantation in a swine myocardial infarct model: Engraftment and functional effects. Ann Thorac Surg 2002, 73:1919-1925. 10.1016/S0003-4975(02)03517-8 12078791
9. Bruder SP Kraus KH Goldberg VM Kadiyala S: The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J Bone Joint Surg Am 1998, 80:985-996. 9698003
10. Kon E Muraglia A Corsi A Bianco P Marcacci M Martin I Boyde A Ruspantini I Chistolini P Rocca M Giardino R Cancedda R Quarto R: Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical-size defects of sheep long bones. J Biomed Mater Res 2000, 49:328-337. 10.1002/ (SICI)1097-4636(20000305)49:3<328::AID-JBM5>3.0.CO;2-Q 10602065
11. Wakitani S Goto T Pineda SJ Young RG Mansour JM Caplan AI Goldberg VM: Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg Am 1994, 76:579-592. 8150826
12. Bruder SP Jaiswal N Ricalton NS Mosca JD Kraus KH Kadiyala S: Mesenchymal stem cells in osteobiology and applied bone regeneration. Clin Orthop Relat Res 1998:S247-S256. 10.1097/00003086-199810001-00025 9917644
13. Johnstone B Hering TM Caplan AI Goldberg VM Yoo JU: In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 1998, 238:265-272. 10.1006/excr.1997.3858 9457080
14. Woodbury D Schwarz EJ Prockop DJ Black IB: Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 2000, 61:364-370. 10.1002/1097-4547(20000815 61:4<364::AID-JNR2>3.0.CO;2-C 10931522
15. Terada N Hamazaki T Oka M Hoki M Mastalerz DM Nakano Y Meyer EM Morel L Petersen BE Scott EW: Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 2002, 416:542-545. 10.1038/ nature730 11932747
16. Dezawa M Takahashi I Esaki M Takano M Sawada H: Sciatic nerve regeneration in rats induced by transplantation of in vitro differentiated bone-marrow stromal cells. Eur J Neurosci 2001, 14:1771-1776. 10.1046/j.0953-816x.2001.01814.x 11860471
17. Horwitz EM Gordon PL Koo WK Marx JC Neel MD McNall RY Muul L Hofmann T: Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone. Proc Natl Acad Sci U S A 2002, 99:8932-8937. 124401 12084934 10.1073/pnas.132252399
18. Koc ON Gerson SL Cooper BW Dyhouse SM Haynesworth SE Caplan AI Lazarus HM: Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol 2000, 18:307-316. 10637244
19. Quarto R Mastrogiacomo M Cancedda R Kutepov SM Mukhachev V Lavroukov A Kon E Marcacci M: Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 2001, 344:385-386. 10.1056/NEJM200102013440516 11195802
20. Petite H Viateau V Bensaid W Meunier A de Pollak C Bourguignon M Oudina K Sedel L Guillemin G: Tissue-engineered bone regeneration. Nat Biotechnol 2000, 18:959-963. 10.1038/79449 10973216
21. Lazarus HM Haynesworth SE Gerson SL Rosenthal NS Caplan AI: Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): Implications for therapeutic use. Bone Marrow Transplant 1995, 16:557-564. 8528172
22. Baldi P Long AD: A Bayesian framework for the analysis of microarray expression data: Regularized t -test and statistical inferences of gene changes. Bioinformatics 2001, 17:509-519. 10.1093/bioinformatics/ 17.6.509 11395427
23. Cheng SL Shao JS Charlton-Kachigian N Loewy AP Towler DA: MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors. J Biol Chem 2003, 278:45969-45977. 10.1074/ jbc.M306972200 12925529
24. Satokata I Ma L Ohshima H Bei M Woo I Nishizawa K Maeda T Takano Y Uchiyama M Heaney S Peters H Tang ZQ Maxson R Maas R: Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nature Genetics 2000, 24:391-395. 10.1038/74231 10742104
25. Jikko A Harris SE Chen D Mendrick DL Damsky CH: Collagen integrin receptors regulate early osteoblast differentiation induced by BMP-2. Journal of Bone and Mineral Research 1999, 14:1075-1083. 10.1359/ jbmr.1999.14.7.1075
26. J.E.A Regulation of osteoblast formation and function. Rev Endocr Metab Disord 2001, 2:81-94. 10.1023/A:1010011209064 11704982
27. Aubin JEl: Bone stem cells. Journal of Cellular Biochemistry 1998, 73:82. 10.1002/(SICI)1097-4644(1998)72:30/31+ <73::AID-JCB11>3.0.CO;2-L 9893258
28. Hartigan JA: Clustering. Annu Rev Biophys Bioeng 1973, 2:81-101. 10.1146/ annurev.bb.02.060173.000501 4583660
29. Biocarta pathway database 2005 http://www.biocarta.com/genes/index.asp
30. Kanehisa M Goto S Kawashima S Nakaya A: The KEGG databases at GenomeNet. Nucleic Acids Res 2002, 30:42-46. 99091 11752249 10.1093/nar/30.1.42
31. Massague J: TGF-beta signal transduction. Annu Rev Biochem 1998, 67:753-791. 10.1146/annurev.biochem.67.1.753 9759503
32. Zwijsen A Verschueren K Huylebroeck D: New intracellular components of bone morphogenetic protein/Smad signaling cascades. FEBS Lett 2003, 546:133-139. 10.1016/S0014-5793(03)00566-0 12829249
33. Wan M Cao X: BMP signaling in skeletal development. Biochem Biophys Res Commun 2005, 328:651-657. 10.1016/j.bbrc.2004.11.067 15694398
34. Ducy P Karsenty G: The family of bone morphogenetic proteins. Kidney Int 2000, 57:2207-2214. 10.1046/j.1523-1755.2000.00081.x 10844590
35. Banfi A Muraglia A Dozin B Mastrogiacomo M Cancedda R Quarto R: Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy. Exp Hematol 2000, 28:707-715. 10.1016/S0301-472X(00)00160-0 10880757
36. Bruder SP Kurth AA Shea M Hayes WC Jaiswal N Kadiyala S: Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells. J Orthop Res 1998, 16:155-162. 10.1002/ jor.1100160202 9621889
37. Stein GS Lian JB: Molecular mechanisms mediating proliferation/ differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr Rev 1993, 14:424-442. 10.1210/er.14.4.424 8223340
38. Kreider BL Benezra R Rovera G Kadesch T: Inhibition of myeloid differentiation by the helix-loop-helix protein Id. Science 1992, 255:1700-1702. 10.1126/science.1372755 1372755
39. Zebedee Z Hara E: Id proteins in cell cycle control and cellular senescence. Oncogene 2001, 20:8317-8325. 10.1038/sj.onc.1205092 11840324
40. Ruzinova MB Benezra R: Id proteins in development, cell cycle and cancer. Trends Cell Biol 2003, 13:410-418. 10.1016/S0962-8924(03)00147-8 12888293
41. Norton JD: ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J Cell Sci 2000, 113 (Pt 22):3897-3905. 11058077
42. Benezra R Aavis RL Lockshon D Turner DL Weintraub H: The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 1990, 61:49-59. 10.1016/0092-8674(90)90214-Y 2156629
43. Pagliuca A Cannada-Bartoli P Lania L: A role for Sp and helix-loop-helix transcription factors in the regulation of the human Id4 gene promoter activity. J Biol Chem 1998, 273:7668-7674. 10.1074/jbc.273.13.7668 9516472
44. Peng Y Kang Q Luo Q Jiang W Si W Liu BA Luu HH Park JK Li X Luo J Montag AG Haydon RC He TC: Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells. J Biol Chem 2004, 279:32941-32949. 10.1074/jbc.M403344200 15161906
45. Derham BK Harding JJ: Alpha-crystallin as a molecular chaperone. Prog Retin Eye Res 1999, 18:463-509. 10.1016/S1350-9462(98)00030-5 10217480
46. Furushima K Shimo-Onoda K Maeda S Nobukuni T Ikari K Koga H Komiya S Nakajima T Harata S Inoue I: Large-scale screening for candidate genes of ossification of the posterior longitudinal ligament of the spine. J Bone Miner Res 2002, 17:128-137. 10.1359/jbmr.2002.17.1.128 11771659
47. Petersen CM Nielsen MS Nykjaer A Jacobsen L Tommerup N Rasmussen HH Roigaard H Gliemann J Madsen P Moestrup SK: Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. J Biol Chem 1997, 272:3599-3605. 10.1074/jbc.272.6.3599 9013611
48. Maeda S Nobukuni T Shimo-Onoda K Hayashi K Yone K Komiya S Inoue I: Sortilin is upregulated during osteoblastic differentiation of mesenchymal stem cells and promotes extracellular matrix mineralization. J Cell Physiol 2002, 193:73-79. 10.1002/jcp.10151 12209882
49. Nohe A Hassel S Ehrlich M Neubauer F Sebald W Henis YI Knaus P: The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways. J Biol Chem 2002, 277:5330-5338. 10.1074/jbc.M102750200 11714695
50. Afzal F Pratap J Ito K Ito Y Stein JL van Wijnen AJ Stein GS Lian JB Javed A: Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription. J Cell Physiol 2005, 204:63-72. 10.1002/jcp.20258 15573378
51. ten Dijke P Goumans MJ Itoh F Itoh S: Regulation of cell proliferation by Smad proteins. J Cell Physiol 2002, 191:1-16. 10.1002/jcp.10066 11920677
52. Pieler R Sanchez-Cabo F Hackl H Thallinger GG Trajanoski Z: ArrayNorm: comprehensive normalization and analysis of microarray data. Bioinformatics 2004, 20:1971-1973. 10.1093/bioinformatics/bth174 15073026
53. StuCn A Quackenbush J Trajanoski Z: Genesis: cluster analysis of microarray data. Bioinformatics 2002, 18:207-208. 10.1093/bioinformatics/ 18.1.207 11836235
54. Harris MA Clark J Ireland A Lomax J Ashburner M Foulger R Eilbeck K Lewis S Marshall B Mungall C Richter J Rubin GM Blake JA Bult C Dolan M Drabkin H Eppig JT Hill DP Ni L Ringwald M Balakrishnan R Cherry JM Christie KR Costanzo MC Dwight SS Engel S Fisk DG Hirschman JE Hong EL Nash RS Sethuraman A Theesfeld CL Botstein D Dolinski K Feierbach B Berardini T Mundodi S Rhee SY Apweiler R Barrell D Camon E Dimmer E Lee V Chisholm R Gaudet P Kibbe W Kishore R Schwarz EM Sternberg P Gwinn M Hannick L Wortman J Berriman M Wood V de la CN Tonellato P Jaiswal P Seigfried T White R: The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res 2004, 32:D258-D261. 308770 14681407 10.1093/ nar/gkh066
55. Mlecnik B Scheideler M Hackl H Hartler J Sanchez-Cabo F Trajanoski Z: PathwayExplorer: Web service for visualizing high-throughput expression data on biological pathways. Nucleic Acids Res 2005, 33:W633-W637. 1160152 15980551 10.1093/nar/gki391
56. Yeung KY Haynor DR Ruzzo WL: Validating clustering for gene expression data. Bioinformatics 2001, 17:309-318. 10.1093/bioinformatics/17.4.309 11301299
57. Maurer M Molidor R Sturn A Hartler J Hackl H Stocker G Prokesch A Mcheideler M Trajanoski Z: MARS: microarray analysis, retrieval, and storage system. BMC Bioinformatics 2005, 6:101-101. 1090551 15836795 10.1186/1471-2105-6-101
58. Brazma A Parkinson H Sarkans U Shojatalab M Vilo J Abeygunawardena N Holloway E Kapushesky M Kemmeren P Lara GG Oezcimen A Rocca-Serra P Sansone SA: ArrayExpress - a public repository for microarray gene expression data at the EBI. Nucleic Acids Res 2003, 31:68-71. 165538 12519949 10.1093/nar/gkg091