NG, a novel PABA/NO-based oleanolic acid derivative, induces Human hepatoma cell apoptosis via a ROS/MAPK-dependent mitochondrial pathway

European Journal of Pharmacology

Volumn 691, Issue 1-3, 2012, Pages 61-68

  Liu, Ling ^a,b   Fu, Junjie ^a   Li, Tingting ^a   Cui, Ran ^a   Ling, Jingjing ^a   Yu, Xing ^a   Ji, Hui ^a   Zhang, Yihua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b HENAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Hepatocellular carcinoma; Nitric oxide; Oleanolic acid; Reactive oxygen species

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 AMINOBENZOIC ACID; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 9; CYTOCHROME C; FLUOROURACIL; HEMOGLOBIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; O [2,4 DINITRO 5 [[2 (12 EN 28 BETA DEXTRO GALACTOPYRANOSYLOLEANOLATE 3 YL) OXY 2 OXOETHYL]AMINO]PHENYL]1 (N HYDROXYETHYLMETHYLAMINO)DIAZEN 1 IUM 1,2 DIOLATE; OLEANOLIC ACID DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER SIZE; CELL STRAIN HEPG2; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION;

4-AMINOBENZOIC ACID; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AZO COMPOUNDS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MITOCHONDRIA; NITRIC OXIDE; OLEANOLIC ACID; REACTIVE OXYGEN SPECIES; SAPONINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84865020408     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.07.031     Document Type: Article

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