Degenerative aortic valve stenosis, but not coronary disease, is associated with shorter telomere length in the elderly

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 26, Issue 6, 2006, Pages

  Kurz, David J ^a,b,c   Kloeckener Gruissem, Barbara ^b   Akhmedov, Alexander ^b   Eberli, Franz R ^a   Bühler, Ines ^a   Berger, Wolfgang ^b   Bertel, Osmund ^c   Lüscher, Thomas F ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c TRIEMLI HOSPITAL   (Switzerland)

Author keywords

Aging; Aortic stenosis; Coronary disease; Risk factors; Telomere

Indexed keywords

ADULT; AORTA VALVE STENOSIS; ARTICLE; CALCIFICATION; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DEGENERATIVE DISEASE; DISEASE PREDISPOSITION; FEMALE; GENETIC ASSOCIATION; HUMAN; HYPOTHESIS; INCIDENCE; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENESCENCE; SOUTHERN BLOTTING; TELOMERE; AGED; AGING; BLOOD; CASE CONTROL STUDY; COHORT ANALYSIS; GENETICS; PILOT STUDY; PROSPECTIVE STUDY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

AGED; AGING; AORTIC VALVE STENOSIS; CASE-CONTROL STUDIES; COHORT STUDIES; CORONARY DISEASE; FEMALE; HUMANS; LEUKOCYTES; MALE; PILOT PROJECTS; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROSPECTIVE STUDIES; TELOMERE;

EID: 33745044044     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000222961.24912.69     Document Type: Article

References (20)

1. Stewart BF, Siscovick D, Lind BK, Gardin JM, Gottdiener JS, Smith VE, Kitzman DW, Otto CM. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J Am Coll Cardiol. 1997;29:630-634.
2. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell. 2005;120:513-522.
3. Blackburn EH. Switching and signaling at the telomere. Cell. 2001;106:661-673.
4. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature. 1990;345:458-460.
5. Chang E, Harley CB. Telomere length and replicative aging in human vascular tissues. Proc Natl Acad Sci U S A. 1995;92:11190-11194.
6. Okuda K, Khan MY, Skurnick J, Kimura M, Aviv H, Aviv A. Telomere attrition of the human abdominal aorta: relationships with age and atherosclerosis. Atherosclerosis. 2000;152:391-398.
7. Slagboom PE, Droog S, Boomsma DI. Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet. 1994;55:876-882.
8. von Zglinicki T, Serra V, Lorenz M, Saretzki G, Lenzen-Grossimlighaus R, Gessner R, Risch A, Steinhagen-Thiessen E. Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor? Lab Invest. 2000;80:1739-1747.
9. Nawrot TS, Staessen JA, Gardner JP, Aviv A. Telomere length and possible link to X chromosome. Lancet. 2004;363:507-510.
10. Vasa-Nicotera M, Brouilette S, Mangino M, Thompson JR, Braund P, Clemitson JR, Mason A, Bodycote CL, Raleigh SM, Louis E, Samani NJ. Mapping of a major locus that determines telomere length in humans. Am J Hum Genet. 2005;76:147-151.
11. Friedrich U, Griese E, Schwab M, Fritz P, Thon K, Klotz U. Telomere length in different tissues of elderly patients. Mech Ageing Dev. 2000;119:89-99.
12. Currie PJ, Hagler DJ, Seward JB, Reeder GS, Fyfe DA, Bove AA, Tajik AJ. Instantaneous pressure gradient: a simultaneous Doppler and dual catheter correlative study. J Am Coll Cardiol. 1986;7:800-806.
13. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res. 2002;30:e47.
14. Broberg K, Bjork J, Paulsson K, Hoglund M, Albin M. Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. Carcinogenesis. 2005;26:1263-1271.
15. Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 2003;361:393-395.
16. Grabowski P, Hultdin M, Karlsson K, Tobin G, Aleskog A, Thunberg U, Laurell A, Sundstrom C, Rosenquist R, Roos G. Telomere length as a prognostic parameter in chronic lymphocytic leukemia with special reference to VH gene mutation status. Blood. 2005;105:4807-4812.
17. Samani NJ, Boultby R, Butler R, Thompson JR, Goodall AH. Telomere shortening in atherosclerosis. Lancet. 2001;358:472-473.
18. Brouilette S, Singh RK, Thompson JR, Goodall AH, Samani NJ. White cell telomere length and risk of premature myocardial infarction. Arterioscler Thromb Vasc Biol. 2003;23:842-846.
19. Erusalimsky JD, Kurz DJ Cellular senescence in vivo: Its relevance in ageing and cardiovascular disease. Exp Gerontol. 2005.
20. Campisi J. Cancer and ageing: rival demons? Nat Rev Cancer. 2003;3:339-349.