KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium

Blood

Volumn 107, Issue 11, 2006, Pages 4354-4363

  Dekker, Rob J ^b   Boon, Reinier A ^b   Rondaij, Mariska G ^b   Kragt, Astrid ^b   Volger, Oscar L ^b   Elderkamp, Yvonne W ^b   Meijers, Joost C M ^b   Voorberg, Jan ^b   Pannekoek, Hans ^b   Horrevoets, Anton J G ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; THROMBIN; THROMBOMODULIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR KLF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2; VON WILLEBRAND FACTOR;

ARTICLE; ATHEROSCLEROSIS; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; CELL MIGRATION; CELL POPULATION; CELL STRUCTURE; CONTROLLED STUDY; ENDOTHELIUM; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENOME ANALYSIS; HEMOSTASIS; HUMAN; HUMAN CELL; INFLAMMATION; LENTIVIRINAE; MARKER GENE; MICROARRAY ANALYSIS; MORPHOLOGY; PRIORITY JOURNAL; PROTEIN SECRETION; SHEAR STRESS; STRESS FIBER; VASCULARIZATION; VASOMOTOR REFLEX; WEIBEL PALADE BODY;

EID: 33646685311     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-08-3465     Document Type: Article

References (45)

1. Ghitescu L, Robert M. Diversity in unity: the biochemical composition of the endothelial cell surface varies between the vascular beds. Microsc Res Tech. 2002;57:381-389.
2. Drake CJ, Hungerford JE, Little CD. Morphogenesis of the first blood vessels. Ann N Y Acad Sci. 1998;857:155-179.
3. Aird WC. Spatial and temporal dynamics of the endothelium. J Thromb Haemost. 2005;3:1392-1406.
4. Ballermann BJ, Ott MJ. Adhesion and differentiation of endothelial cells by exposure to chronic shear stress: a vascular graft model. Blood Purif. 1995;13:125-134.
5. Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C. Roles of hemodynamic forces in vascular cell differentiation. Ann Biomed Eng. 2005;33:772-779.
6. Dekker RJ, van Soest S, Fontijn RD, et al. Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2). Blood. 2002;100:1689-1698.
7. SenBanerjee S, Lin Z, Atkins GB, et al. KLF2 is a novel transcriptional regulator of endothelial proinflammatory ctivation. J Exp Med. 2004;199:1305-1315.
8. Lin Z, Kumar A, SenBfanerjee S, et al. Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circ Res. 2005;96:e48-e57.
9. Bhattacharya R, Senbanerjee S, Lin Z, et al. Inhibition of vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis by the Kruppel-like factor KLF2. J Biol Chem. 2005;280:28848-28851.
10. Dekker RJ, van Thienen JV, Rohlena J, et al. Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes. Am J Pathol. 2005;167:609-618.
11. Kuo CT, Veselits ML, Barton KP, Lu MM, Clendenin C, Leiden JM. The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes Dev. 1997;11:2996-3006.
12. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins: identification by morphologic and immunologic criteria. J Clin Invest. 1973;52:2745-2756.
13. Baldi P, Long AD. A Bayesian framework for the analysis of microarray expression data: regularized t-test and statistical inferences of gene changes. Bioinformatics. 2001;17:509-519.
14. National Center for Biotechnology Information. LocusLink. http://www.ncbi.nlm.nih.gov/LocusLink/. Accessed April 26, 2005.
15. Doniger SW, Salomonis N, Dahlquist KD, Vranizan K, Lawlor SC, Conklin BR. MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data. Genome Biology. 2003;4:R7.
16. Rozen S, Skaletsky HJ. Primer3 on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S, eds. Bioinformatics Methods and Protocols: Methods in Molecular Biology. Totowa, NJ: Humana Press; 2000:365-386.
17. Fontijn RD, Goud B, Echard A, et al. The human kinesin-like protein RB6K is under tight cell cycle control and is essential for cytokinesis. Mol Cell Biol. 2001;21:2944-2955.
18. Romani de Wit T, Rondaij MG, Hordijk PL, Voorberg J, van Mourik JA. Real-time imaging of the dynamics and secretory behavior of Weibel-Palade bodies. Arterioscler Thromb Vasc Biol. 2003;23:755-761.
19. Yang HL, Hseu YC, Lu FJ, Tsai HD. Humic acid reduces protein-C-activating cofactor activity of thrombomodulin of human umbilical vein endothelial cells. Br J Haematol. 1998;101:16-23.
20. Malinda KM, Goldstein AL, Kleinman HK. Thymosin beta 4 stimulates directional migration of human umbilical vein endothelial cells. FASEB J. 1997;11:474-481.
21. Rondaij MG, Sellink E, Gijzen KA, et al. Small GTP-binding protein Ral is involved in cAMP-mediated release of von Willebrand factor from endothelial cells. Arterioscler Thromb Vasc Biol. 2004;24:1315-1320.
22. Daniel TO, Abrahamson D. Endothelial signal integration in vascular assembly. Annu Rev Physiol. 2000;62:649-671.
23. Harvey NL, Oliver G. Choose your fate: artery, vein or lymphatic vessel? Curr Opin Genet Dev. 2004;14:499-505.
24. The Gene Ontology Consortium. The Gene Ontology. http://www.geneontology. org. Accessed March 8, 2005.
25. Bielenberg DR, Hida Y, Shimizu A, et al. Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype. J Clin Invest. 2004;114:1260-1271.
26. Conway EM, Rosenberg RD. Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Mol Cell Biol. 1988;8:5588-5892.
27. Zhang J, Patel JM, Li YD, Block ER. Proinflammatory cytokines downregulate gene expression and activity of constitutive nitric oxide synthase in porcine pulmonary artery endothelial cells. Res Commun Mol Pathol Pharmacol. 1997;96:71-87.
28. van den Berg EA, Sprengers ED, Jaye M, Burgess W, Maciag T, van Hinsbergh VW. Regulation of plasminogen activator inhibitor-1 mRNA in human endothelial cells. Thromb Haemost. 1988;60:63-67.
29. Horrevoets AJ, Tans G, Smilde AE, van Zonneveld AJ, Pannekoek H. Thrombin-variable region 1 (VR1): evidence for the dominant contribution of VR1 of serine proteases to their interaction with plasminogen activator inhibitor 1. J Biol Chem. 1993;268:779-782.
30. Lijnen HR. Plasmin and matrix metalloproteinases in vascular remodeling. Thromb Haemost. 2001;86:324-333.
31. Bai Y, Soda Y, Izawa K, et al. Effective transduction and stable transgene expression in human blood cells by a third-generation lentiviral vector. Gene Ther. 2003;10:1446-1457.
32. Ignarro LJ. Signal transduction mechanisms involving nitric oxide. Biochem Pharmacol. 1991;41:485-490.
33. Braam B, de Roos R, Dijk A, et al. Nitric oxide donor induces temporal and dose-dependent reduction of gene expression in human endothelial cells. Am J Physiol Heart Circ Physiol. 2004;287:H1977-H1986.
34. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. Vascular-specific growth factors and blood vessel formation. Nature. 2000;407:242-248.
35. Hogan KA, Bautch VL. Blood vessel patterning at the embryonic midline. Curr Top Dev Biol. 2004;62:55-85.
36. Topper JN, Cai J, Stavrakis G, et al. Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo. Circulation. 1998;98:2396-2403.
37. Isogai C, Laug WE, Shimada H, et al. Plasminogen activator inhibitor-1 promotes angiogenesis by stimulating endothelial cell migration toward fibronectin. Cancer Res. 2001;61:5587-5594.
38. Healy AM, Rayburn HB, Rosenberg RD, Weiler H. Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Proc Natl Acad Sci USA. 1995;92:850-854.
39. Van de Wouwer M, Collen D, Conway EM. Thrombomodulin-protein C-EPCR system: integrated to regulate coagulation and inflammation. Arterioscler Thromb Vasc Biol. 2004;24:1374-1383.
40. Zeng H, Sanyal S, Mukhopadhyay D. Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor/vascular endothelial growth factor-induced endothelium migration and proliferation, respectively. J Biol Chem. 2001;276:32714-32719.
41. Matsumoto T, Bohman S, Dixelius J, et al. VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis. EMBO J. 2005;24:2342-2353.
42. Shalaby F, Rossant J, Yamaguchi TP, et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature. 1995;376:62-65.
43. Horrevoets AJ, Fontijn RD, van Zonneveld AJ, de Vries CJ, ten Cate JW, Pannekoek H. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. Blood. 1999;93:3418-3431.
44. Methia N, Andre P, Denis CV, Economopoulos M, Wagner DD. Localized reduction of atherosclerosis in von Willebrand factor-deficient mice. Blood. 2001;98:1424-1428.
45. Esmon CT. Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. FASEB J. 1995;9:946-955.