Membrane androgen receptor sensitive Na+/H+ exchanger activity in prostate cancer cells

FEBS Letters

Volumn 588, Issue 9, 2014, Pages 1571-1579

  Chatterjee, Soumya ^a   Schmidt, Sebastian ^a   Pouli, Stella ^b   Honisch, Sabina ^a   Alkahtani, Saad ^b,c   Stournaras, Christos ^a,b   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF CRETE   (Greece)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Actin; Cytosolic pH; EMD638683; ROCK; SGK1; Y 27632

Indexed keywords

ALBUMIN CONJUGATE; ANDROGEN RECEPTOR; CARIPORIDE; G ACTIN; MEMBRANE ANDROGEN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; RHO KINASE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN 2; TESTOSTERONE ALBUMIN CONJUGATE; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ALKALINIZATION; ARTICLE; CANCER CELL CULTURE; CELL STIMULATION; CELL VOLUME; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOSOLIC PH; ENZYME ACTIVITY; ENZYME INHIBITION; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; PH; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTON SODIUM EXCHANGE; REALKALINIZATION;

ACTIN; CYTOSOLIC PH; EMD638683; NA(+)/H(+) EXCHANGER; ROCK; SGK1; Y-27632;

AMIDES; BENZAMIDES; BENZOATES; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE, TUMOR; CELL MEMBRANE; CELL SIZE; GUANIDINES; HUMANS; HYDRAZINES; HYDROGEN-ION CONCENTRATION; IMMEDIATE-EARLY PROTEINS; MALE; PROSTATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RECEPTORS, ANDROGEN; RHO-ASSOCIATED KINASES; SODIUM-HYDROGEN ANTIPORTER; SULFONES;

EID: 84899627726     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.02.040     Document Type: Article

References (52)

1. N. Papadopoulou, I. Charalampopoulos, K. Alevizopoulos, A. Gravanis, and C. Stournaras Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cells Exp. Cell Res. 314 2008 3162 3174
2. E.A. Papakonstanti, M. Kampa, E. Castanas, and C. Stournaras A rapid, nongenomic, signaling pathway regulates the actin reorganization induced by activation of membrane testosterone receptors Mol. Endocrinol. 17 2003 870 881
3. G. Kallergi, S. Agelaki, H. Markomanolaki, V. Georgoulias, and C. Stournaras Activation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells Cell. Physiol. Biochem. 20 2007 977 986
4. M. Kampa, V. Pelekanou, and E. Castanas Membrane-initiated steroid action in breast and prostate cancer Steroids 73 2008 953 960
5. S. Gu, N. Papadopoulou, E.M. Gehring, O. Nasir, K. Dimas, S.K. Bhavsar, M. Foller, K. Alevizopoulos, F. Lang, and C. Stournaras Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivo Mol. Cancer 8 2009 114
6. E.M. Schmidt, S. Gu, V. Anagnostopoulou, K. Alevizopoulos, M. Foller, F. Lang, and C. Stournaras Serum- and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor FEBS J. 279 2012 1231 1242
7. S. Gu, N. Papadopoulou, O. Nasir, M. Foller, K. Alevizopoulos, F. Lang, and C. Stournaras Activation of membrane androgen receptors in colon cancer inhibits the prosurvival signals Akt/bad in vitro and in vivo and blocks migration via vinculin/actin signaling Mol. Med. 17 2011 48 58
8. N. Papadopoulou, I. Charalampopoulos, V. Anagnostopoulou, G. Konstantinidis, M. Foller, A. Gravanis, K. Alevizopoulos, F. Lang, and C. Stournaras Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells Mol. Cancer 7 2008 88
9. D. Aki, Y. Minoda, H. Yoshida, S. Watanabe, R. Yoshida, G. Takaesu, T. Chinen, T. Inaba, M. Hikida, T. Kurosaki, K. Saeki, and A. Yoshimura Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells Genes Cells 13 2008 199 208
10. N. Papadopoulou, E.A. Papakonstanti, G. Kallergi, K. Alevizopoulos, and C. Stournaras Membrane androgen receptor activation in prostate and breast tumor cells: molecular signaling and clinical impact IUBMB Life 61 2009 56 61
11. M. Kampa, C. Kogia, P.A. Theodoropoulos, P. Anezinis, I. Charalampopoulos, E.A. Papakonstanti, E.N. Stathopoulos, A. Hatzoglou, C. Stournaras, A. Gravanis, and E. Castanas Activation of membrane androgen receptors potentiates the antiproliferative effects of paclitaxel on human prostate cancer cells Mol. Cancer Ther. 5 2006 1342 1351
12. A. Hatzoglou, M. Kampa, C. Kogia, I. Charalampopoulos, P.A. Theodoropoulos, P. Anezinis, C. Dambaki, E.A. Papakonstanti, E.N. Stathopoulos, C. Stournaras, A. Gravanis, and E. Castanas Membrane androgen receptor activation induces apoptotic regression of human prostate cancer cells in vitro and in vivo J. Clin. Endocrinol. Metab. 90 2005 893 903
13. F. Lang, K. Alevizopoulos, and C. Stournaras Targeting membrane androgen receptors in tumors Expert Opin. Ther. Targets 17 2013 951 963
14. P. De Vito The sodium/hydrogen exchanger: a possible mediator of immunity Cell. Immunol. 240 2006 69 85
15. T.A. Heming, and A. Bidani Na(+)-H+ exchange in resident alveolar macrophages: activation by osmotic cell shrinkage J. Leukoc. Biol. 57 1995 609 616
16. E.K. Hoffmann, I.H. Lambert, and S.F. Pedersen Physiology of cell volume regulation in vertebrates Physiol. Rev. 89 2009 193 277
17. F. Lang, G.L. Busch, M. Ritter, H. Volkl, S. Waldegger, E. Gulbins, and D. Haussinger Functional significance of cell volume regulatory mechanisms Physiol. Rev. 78 1998 247 306
18. L. Fliegel The Na+/H+ exchanger isoform 1 Int. J. Biochem. Cell Biol. 37 2005 33 37
19. J. Luo, and D. Sun Physiology and pathophysiology of Na(+)/H(+) exchange isoform 1 in the central nervous system Curr. Neurovasc. Res. 4 2007 205 215
20. J. Orlowski, and S. Grinstein Diversity of the mammalian sodium/proton exchanger SLC9 gene family Pflugers Arch. 447 2004 549 565
21. F. Lang, J. Madlung, J. Bock, U. Lukewille, S. Kaltenbach, K.S. Lang, C. Belka, C.A. Wagner, H.J. Lang, E. Gulbins, and A. Lepple-Wienhues Inhibition of Jurkat-T-lymphocyte Na+/H+-exchanger by CD95(Fas/Apo-1)-receptor stimulation Pflugers Arch. 440 2000 902 907
22. T. Tominaga, and D.L. Barber Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading Mol. Biol. Cell 9 1998 2287 2303
23. J. Voelkl, V. Pasham, M.S. Ahmed, B. Walker, K. Szteyn, D. Kuhl, B. Metzler, I. Alesutan, and F. Lang Sgk1-dependent stimulation of cardiac Na+/H+ exchanger Nhe1 by dexamethasone Cell. Physiol. Biochem. 32 2013 25 38
24. M. Bhandaru, V. Pasham, W. Yang, D. Bobbala, A. Rotte, and F. Lang Effect of azathioprine on Na(+)/H(+) exchanger activity in dendritic cells Cell. Physiol. Biochem. 29 2012 533 542
25. A. Rotte, V. Pasham, M. Eichenmuller, W. Yang, M. Bhandaru, and F. Lang Influence of dexamethasone on Na+/H+ exchanger activity in dendritic cells Cell. Physiol. Biochem. 28 2011 305 314
26. A. Rotte, V. Pasham, M. Eichenmuller, M. Bhandaru, M. Foller, and F. Lang Upregulation of Na+/H+ exchanger by the AMP-activated protein kinase Biochem. Biophys. Res. Commun. 398 2010 677 682
27. S.J. Waisbren, J. Geibel, W.F. Boron, and I.M. Modlin Luminal perfusion of isolated gastric glands Am. J. Physiol. 266 1994 C1013 C1027
28. A. Roos, and W.F. Boron Intracellular pH Physiol. Rev. 61 1981 296 434
29. A. Rotte, V. Pasham, M. Bhandaru, D. Bobbala, C. Zelenak, and F. Lang Rapamycin sensitive ROS formation and Na(+)/H(+) exchanger activity in dendritic cells Cell. Physiol. Biochem. 29 2012 543 550
30. G. Boyarsky, M.B. Ganz, R.B. Sterzel, and W.F. Boron PH regulation in single glomerular mesangial cells. I. Acid extrusion in absence and presence of HCO3- Am. J. Physiol. 255 1988 C844 C856
31. W. Yang, M. Bhandaru, V. Pasham, D. Bobbala, C. Zelenak, K. Jilani, A. Rotte, and F. Lang Effect of thymoquinone on cytosolic pH and Na+/H+ exchanger activity in mouse dendritic cells Cell. Physiol. Biochem. 29 2012 21 30
32. E.A. Papakonstanti, and C. Stournaras Actin cytoskeleton architecture and signaling in osmosensing Methods Enzymol. 428 2007 227 240
33. E. Boedtkjer, L. Bunch, and S.F. Pedersen Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: similarities, differences, and implications for cancer therapy Curr. Pharm. Des. 18 2012 1345 1371
34. P.A. Theodoropoulos, C. Stournaras, B. Stoll, E. Markogiannakis, F. Lang, A. Gravanis, and D. Haussinger Hepatocyte swelling leads to rapid decrease of the G-/total actin ratio and increases actin mRNA levels FEBS Lett. 311 1992 241 245
35. A. Moustakas, P.A. Theodoropoulos, A. Gravanis, D. Haussinger, and C. Stournaras The cytoskeleton in cell volume regulation Contrib. Nephrol. 123 1998 121 134
36. E.A. Papakonstanti, E.A. Vardaki, and C. Stournaras Actin cytoskeleton: a signaling sensor in cell volume regulation Cell. Physiol. Biochem. 10 2000 257 264
37. K. Szaszi, S. Grinstein, J. Orlowski, and A. Kapus Regulation of the epithelial Na(+) /H(+) exchanger isoform by the cytoskeleton Cell. Physiol. Biochem. 10 2000 265 272
38. F. Alimirah, J. Chen, Z. Basrawala, H. Xin, and D. Choubey DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation FEBS Lett. 580 2006 2294 2300
39. S. Mitchell, P. Abel, M. Ware, G. Stamp, and E.N. Lalani Phenotypic and genotypic characterization of commonly used human prostatic cell lines Bju Int. 85 2000 932 944
40. Y. Shi, H. Yuan, D. Kim, V. Chanana, A. Baba, T. Matsuda, P. Cengiz, P. Ferrazzano, and D. Sun Stimulation of na(+)/h(+) exchanger isoform 1 promotes microglial migration PLoS ONE 8 2013 e74201
41. A. Rotte, V. Pasham, W. Yang, M. Eichenmuller, M. Bhandaru, E. Shumilina, and F. Lang Phosphoinositide 3-kinase-dependent regulation of Na+/H+ exchanger in dendritic cells Pflugers Arch. 460 2010 1087 1096
42. M. Bhandaru, W. Yang, A. Rotte, V. Pasham, and F. Lang Regulation of Na+/H+ exchanger in dendritic cells by Akt2 Pflugers Arch. 463 2012 355 363
43. L.M. Henderson, J.B. Chappell, and O.T. Jones Internal pH changes associated with the activity of NADPH oxidase of human neutrophils. Further evidence for the presence of an H+ conducting channel Biochem. J. 251 1988 563 567
44. C.J. Swallow, S. Grinstein, R.A. Sudsbury, and O.D. Rotstein Relative roles of Na+/H+ exchange and vacuolar-type H+ ATPases in regulating cytoplasmic pH and function in murine peritoneal macrophages J. Cell. Physiol. 157 1993 453 460
45. V. Pasham, A. Rotte, W. Yang, C. Zelenak, M. Bhandaru, M. Foller, and F. Lang OSR1-sensitive regulation of Na+/H+ exchanger activity in dendritic cells Am. J. Physiol. Cell Physiol. 303 2012 C416 426
46. A. Bellocq, S. Suberville, C. Philippe, F. Bertrand, J. Perez, B. Fouqueray, G. Cherqui, and L. Baud Low environmental pH is responsible for the induction of nitric-oxide synthase in macrophages. Evidence for involvement of nuclear factor-kappaB activation J. Biol. Chem. 273 1998 5086 5092
47. P. Dieter, A. Schulze-Specking, U. Karck, and K. Decker Prostaglandin release but not superoxide production by rat Kupffer cells stimulated in vitro depends on Na+/H+ exchange Eur. J. Biochem. 170 1987 201 206
48. Z.H. Nemeth, J.G. Mabley, E.A. Deitch, C. Szabo, and G. Hasko Inhibition of the Na(+)/H(+) antiporter suppresses IL-12 p40 production by mouse macrophages Biochim. Biophys. Acta 1539 2001 233 242
49. V. Prpic, S.F. Yu, F. Figueiredo, P.W. Hollenbach, G. Gawdi, B. Herman, R.J. Uhing, and D.O. Adams Role of Na+/H+ exchange by interferon-gamma in enhanced expression of JE and I-A beta genes Science 244 1989 469 471
50. M.W. Rolfe, S.L. Kunkel, B. Rowens, T.J. Standiford, E.J. Cragoe Jr., and R.M. Strieter Suppression of human alveolar macrophage-derived cytokines by amiloride Am. J. Respir. Cell Mol. Biol. 6 1992 576 582
51. C.J. Swallow, S. Grinstein, and O.D. Rotstein Regulation and functional significance of cytoplasmic pH in phagocytic leukocytes S. Grinstein, O.D. Rotstein, Mechanisms of Leukocytes Activation Current Topics in Membranes and Transport 1990 Academic Press Inc. New York 227 247
52. G. Vairo, S. Argyriou, A.M. Bordun, T.J. Gonda, E.J. Cragoe Jr., and J.A. Hamilton Na+/H+ exchange involvement in colony-stimulating factor-1-stimulated macrophage proliferation. Evidence for a requirement during late G1 of the cell cycle but not for early growth factor responses J. Biol. Chem. 265 1990 16929 16939