-
1
-
-
84879415211
-
Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway
-
L. Adesso, S. Calabretta, F. Barbagallo, G. Capurso, E. Pilozzi, R. Geremia, G. Delle Fave, and C. Sette Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway Oncogene 32 2013 2848 2857
-
(2013)
Oncogene
, vol.32
, pp. 2848-2857
-
-
Adesso, L.1
Calabretta, S.2
Barbagallo, F.3
Capurso, G.4
Pilozzi, E.5
Geremia, R.6
Delle Fave, G.7
Sette, C.8
-
2
-
-
84879720960
-
Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors
-
J.K. Altman, A. Szilard, B.W. Konicek, P.W. Iversen, B. Kroczynska, H. Glaser, A. Sassano, E. Vakana, J.R. Graff, and L.C. Platanias Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors Blood 121 2013 3675 3681
-
(2013)
Blood
, vol.121
, pp. 3675-3681
-
-
Altman, J.K.1
Szilard, A.2
Konicek, B.W.3
Iversen, P.W.4
Kroczynska, B.5
Glaser, H.6
Sassano, A.7
Vakana, E.8
Graff, J.R.9
Platanias, L.C.10
-
3
-
-
67651089847
-
Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): A proof-of-principle clinical trial with ribavirin
-
S. Assouline, B. Culjkovic, E. Cocolakis, C. Rousseau, N. Beslu, A. Amri, S. Caplan, B. Leber, D.-C. Roy, W.H. Miller Jr., and K.L. Borden Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin Blood 114 2009 257 260
-
(2009)
Blood
, vol.114
, pp. 257-260
-
-
Assouline, S.1
Culjkovic, B.2
Cocolakis, E.3
Rousseau, C.4
Beslu, N.5
Amri, A.6
Caplan, S.7
Leber, B.8
Roy, D.-C.9
Miller Jr., W.H.10
Borden, K.L.11
-
4
-
-
36549040859
-
The selectivity of protein kinase inhibitors: A further update
-
J. Bain, L. Plater, M. Elliott, N. Shpiro, C.J. Hastie, H. McLauchlan, I. Klevernic, J.S.C. Arthur, D.R. Alessi, and P. Cohen The selectivity of protein kinase inhibitors: a further update Biochem. J. 408 2007 297 315
-
(2007)
Biochem. J.
, vol.408
, pp. 297-315
-
-
Bain, J.1
Plater, L.2
Elliott, M.3
Shpiro, N.4
Hastie, C.J.5
McLauchlan, H.6
Klevernic, I.7
Arthur, J.S.C.8
Alessi, D.R.9
Cohen, P.10
-
5
-
-
0030066934
-
Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation
-
L. Beretta, A.C. Gingras, Y.V. Svitkin, M.N. Hall, and N. Sonenberg Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation EMBO J. 15 1996 658 664
-
(1996)
EMBO J.
, vol.15
, pp. 658-664
-
-
Beretta, L.1
Gingras, A.C.2
Svitkin, Y.V.3
Hall, M.N.4
Sonenberg, N.5
-
6
-
-
57349100323
-
Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells
-
A. Bianchini, M. Loiarro, P. Bielli, R. Busà, M.P. Paronetto, F. Loreni, R. Geremia, and C. Sette Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells Carcinogenesis 29 2008 2279 2288
-
(2008)
Carcinogenesis
, vol.29
, pp. 2279-2288
-
-
Bianchini, A.1
Loiarro, M.2
Bielli, P.3
Busà, R.4
Paronetto, M.P.5
Loreni, F.6
Geremia, R.7
Sette, C.8
-
7
-
-
84858589998
-
Targeting the oncogene eIF4E in cancer: From the bench to clinical trials
-
K.L.B. Borden Targeting the oncogene eIF4E in cancer: from the bench to clinical trials Clin. Invest. Med. 34 2011 E315 E319
-
(2011)
Clin. Invest. Med.
, vol.34
-
-
Borden, K.L.B.1
-
8
-
-
23844516065
-
The Mnks are novel components in the control of TNF α biosynthesis and phosphorylate and regulate hnRNP A1
-
M. Buxadé, J.L. Parra, S. Rousseau, N. Shpiro, R. Marquez, N. Morrice, J. Bain, E. Espel, and C.G. Proud The Mnks are novel components in the control of TNF α biosynthesis and phosphorylate and regulate hnRNP A1 Immunity 23 2005 177 189
-
(2005)
Immunity
, vol.23
, pp. 177-189
-
-
Buxadé, M.1
Parra, J.L.2
Rousseau, S.3
Shpiro, N.4
Marquez, R.5
Morrice, N.6
Bain, J.7
Espel, E.8
Proud, C.G.9
-
9
-
-
52049088725
-
The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)
-
M. Buxade, J.L. Parra-Palau, and C.G. Proud The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases) Front. Biosci. 13 2008 5359 5373
-
(2008)
Front. Biosci.
, vol.13
, pp. 5359-5373
-
-
Buxade, M.1
Parra-Palau, J.L.2
Proud, C.G.3
-
10
-
-
19744364796
-
Structural bioinformatics-based design of selective, irreversible kinase inhibitors
-
M.S. Cohen, C. Zhang, K.M. Shokat, and J. Taunton Structural bioinformatics-based design of selective, irreversible kinase inhibitors Science 308 2005 1318 1321
-
(2005)
Science
, vol.308
, pp. 1318-1321
-
-
Cohen, M.S.1
Zhang, C.2
Shokat, K.M.3
Taunton, J.4
-
11
-
-
33846648989
-
Controlling gene expression through RNA regulons: The role of the eukaryotic translation initiation factor eIF4E
-
B. Culjkovic, I. Topisirovic, and K.L.B. Borden Controlling gene expression through RNA regulons: the role of the eukaryotic translation initiation factor eIF4E Cell Cycle 6 2007 65 69
-
(2007)
Cell Cycle
, vol.6
, pp. 65-69
-
-
Culjkovic, B.1
Topisirovic, I.2
Borden, K.L.B.3
-
12
-
-
2342489456
-
EIF-4E expression and its role in malignancies and metastases
-
A. De Benedetti, and J.R. Graff eIF-4E expression and its role in malignancies and metastases Oncogene 23 2004 3189 3199
-
(2004)
Oncogene
, vol.23
, pp. 3189-3199
-
-
De Benedetti, A.1
Graff, J.R.2
-
13
-
-
43749107283
-
Comparative protein structure modeling using Modeller
-
5.6
-
N. Eswar, B. Webb, M.A. Marti-Renom, M. Madhusudhan, D. Eramian, M.Y. Shen, U. Pieper, and A. Sali Comparative protein structure modeling using Modeller Curr. Protoc. Bioinformatics 5 2006 5.6
-
(2006)
Curr. Protoc. Bioinformatics
, vol.5
-
-
Eswar, N.1
Webb, B.2
Marti-Renom, M.A.3
Madhusudhan, M.4
Eramian, D.5
Shen, M.Y.6
Pieper, U.7
Sali, A.8
-
14
-
-
85046915181
-
Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues
-
S. Fan, S.S. Ramalingam, J. Kauh, Z. Xu, F.R. Khuri, and S.Y. Sun Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues Cancer Biol. Ther. 8 2009 1463 1469
-
(2009)
Cancer Biol. Ther.
, vol.8
, pp. 1463-1469
-
-
Fan, S.1
Ramalingam, S.S.2
Kauh, J.3
Xu, Z.4
Khuri, F.R.5
Sun, S.Y.6
-
15
-
-
84882291342
-
Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity
-
K. Feoktistova, E. Tuvshintogs, A. Do, and C.S. Fraser Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity Proc. Natl. Acad. Sci. USA 110 2013 13339 13344
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 13339-13344
-
-
Feoktistova, K.1
Tuvshintogs, E.2
Do, A.3
Fraser, C.S.4
-
16
-
-
77956275419
-
EIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
-
L. Furic, L. Rong, O. Larsson, I.H. Koumakpayi, K. Yoshida, A. Brueschke, E. Petroulakis, N. Robichaud, M. Pollak, and L.A. Gaboury et al. eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression Proc. Natl. Acad. Sci. USA 107 2010 14134 14139
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 14134-14139
-
-
Furic, L.1
Rong, L.2
Larsson, O.3
Koumakpayi, I.H.4
Yoshida, K.5
Brueschke, A.6
Petroulakis, E.7
Robichaud, N.8
Pollak, M.9
Gaboury, L.A.10
-
17
-
-
34848901974
-
Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity
-
J.R. Graff, B.W. Konicek, T.M. Vincent, R.L. Lynch, D. Monteith, S.N. Weir, P. Schwier, A. Capen, R.L. Goode, and M.S. Dowless et al. Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity J. Clin. Invest. 117 2007 2638 2648
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2638-2648
-
-
Graff, J.R.1
Konicek, B.W.2
Vincent, T.M.3
Lynch, R.L.4
Monteith, D.5
Weir, S.N.6
Schwier, P.7
Capen, A.8
Goode, R.L.9
Dowless, M.S.10
-
18
-
-
80054114844
-
A phase 1 dose escalation, pharmacokinetic, and pharmacodynamic evaluation of eIF-4E antisense oligonucleotide LY2275796 in patients with advanced cancer
-
D.S. Hong, R. Kurzrock, Y. Oh, J. Wheler, A. Naing, L. Brail, S. Callies, V. André, S.K. Kadam, and A. Nasir et al. A phase 1 dose escalation, pharmacokinetic, and pharmacodynamic evaluation of eIF-4E antisense oligonucleotide LY2275796 in patients with advanced cancer Clin. Cancer Res. 17 2011 6582 6591
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 6582-6591
-
-
Hong, D.S.1
Kurzrock, R.2
Oh, Y.3
Wheler, J.4
Naing, A.5
Brail, L.6
Callies, S.7
André, V.8
Kadam, S.K.9
Nasir, A.10
-
20
-
-
84881451886
-
Insights into the importance of DFD-motif and insertion I1 in stabilizing the DFD-out conformation of Mnk2 kinase
-
J. Hou, T. Teo, M.J. Sykes, and S. Wang Insights into the importance of DFD-motif and insertion I1 in stabilizing the DFD-out conformation of Mnk2 kinase ACS Med. Chem. Lett. 4 2013 736 741
-
(2013)
ACS Med. Chem. Lett.
, vol.4
, pp. 736-741
-
-
Hou, J.1
Teo, T.2
Sykes, M.J.3
Wang, S.4
-
21
-
-
26444592983
-
Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site
-
R. Jauch, S. Jäkel, C. Netter, K. Schreiter, B. Aicher, H. Jäckle, and M.C. Wahl Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site Structure 13 2005 1559 1568
-
(2005)
Structure
, vol.13
, pp. 1559-1568
-
-
Jauch, R.1
Jäkel, S.2
Netter, C.3
Schreiter, K.4
Aicher, B.5
Jäckle, H.6
Wahl, M.C.7
-
22
-
-
33748358167
-
Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment
-
R. Jauch, M.K. Cho, S. Jäkel, C. Netter, K. Schreiter, B. Aicher, M. Zweckstetter, H. Jäckle, and M.C. Wahl Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment EMBO J. 25 2006 4020 4032
-
(2006)
EMBO J.
, vol.25
, pp. 4020-4032
-
-
Jauch, R.1
Cho, M.K.2
Jäkel, S.3
Netter, C.4
Schreiter, K.5
Aicher, B.6
Zweckstetter, M.7
Jäckle, H.8
Wahl, M.C.9
-
23
-
-
38049018155
-
A quantitative analysis of kinase inhibitor selectivity
-
M.W. Karaman, S. Herrgard, D.K. Treiber, P. Gallant, C.E. Atteridge, B.T. Campbell, K.W. Chan, P. Ciceri, M.I. Davis, and P.T. Edeen et al. A quantitative analysis of kinase inhibitor selectivity Nat. Biotechnol. 26 2008 127 132
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 127-132
-
-
Karaman, M.W.1
Herrgard, S.2
Treiber, D.K.3
Gallant, P.4
Atteridge, C.E.5
Campbell, B.T.6
Chan, K.W.7
Ciceri, P.8
Davis, M.I.9
Edeen, P.T.10
-
24
-
-
11144220618
-
Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap
-
A. Kentsis, I. Topisirovic, B. Culjkovic, L. Shao, and K.L. Borden Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap Proc. Natl. Acad. Sci. USA 101 2004 18105 18110
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 18105-18110
-
-
Kentsis, A.1
Topisirovic, I.2
Culjkovic, B.3
Shao, L.4
Borden, K.L.5
-
25
-
-
0034928792
-
Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2
-
U. Knauf, C. Tschopp, and H. Gram Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2 Mol. Cell. Biol. 21 2001 5500 5511
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5500-5511
-
-
Knauf, U.1
Tschopp, C.2
Gram, H.3
-
26
-
-
79952223149
-
Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases
-
B.W. Konicek, J.R. Stephens, A.M. McNulty, N. Robichaud, R.B. Peery, C.A. Dumstorf, M.S. Dowless, P.W. Iversen, S. Parsons, and K.E. Ellis et al. Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases Cancer Res. 71 2011 1849 1857
-
(2011)
Cancer Res.
, vol.71
, pp. 1849-1857
-
-
Konicek, B.W.1
Stephens, J.R.2
McNulty, A.M.3
Robichaud, N.4
Peery, R.B.5
Dumstorf, C.A.6
Dowless, M.S.7
Iversen, P.W.8
Parsons, S.9
Ellis, K.E.10
-
27
-
-
75349091799
-
Defining the conserved internal architecture of a protein kinase
-
A.P. Kornev, and S.S. Taylor Defining the conserved internal architecture of a protein kinase Biochim. Biophys. Acta 1804 2010 440 444
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 440-444
-
-
Kornev, A.P.1
Taylor, S.S.2
-
28
-
-
33845197964
-
Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism
-
A.P. Kornev, N.M. Haste, S.S. Taylor, and L.F. Eyck Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism Proc. Natl. Acad. Sci. USA 103 2006 17783 17788
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 17783-17788
-
-
Kornev, A.P.1
Haste, N.M.2
Taylor, S.S.3
Eyck, L.F.4
-
29
-
-
58149102648
-
Type-II kinase inhibitor docking, screening, and profiling using modified structures of active kinase states
-
I. Kufareva, and R. Abagyan Type-II kinase inhibitor docking, screening, and profiling using modified structures of active kinase states J. Med. Chem. 51 2008 7921 7932
-
(2008)
J. Med. Chem.
, vol.51
, pp. 7921-7932
-
-
Kufareva, I.1
Abagyan, R.2
-
30
-
-
84949179572
-
Cap-dependent protein translation initiation in multiple myeloma: An attractive target for therapy
-
S. Lentzsch, Springer New York
-
S. Li, J. Fu, and M. Suzanne Lentzsch Cap-dependent protein translation initiation in multiple myeloma: an attractive target for therapy S. Lentzsch, Genetic and Molecular Epidemiology of Multiple Myeloma 2013 Springer New York 43 57
-
(2013)
Genetic and Molecular Epidemiology of Multiple Myeloma
, pp. 43-57
-
-
Li, S.1
Fu, J.2
Suzanne Lentzsch, M.3
-
31
-
-
84876277464
-
Upregulation of the eIF4E signaling pathway contributes to the progression of gastric cancer, and targeting eIF4E by perifosine inhibits cell growth
-
S. Liang, R. Guo, Z. Zhang, D. Liu, H. Xu, Z. Xu, X. Wang, and L. Yang Upregulation of the eIF4E signaling pathway contributes to the progression of gastric cancer, and targeting eIF4E by perifosine inhibits cell growth Oncol. Rep. 29 2013 2422 2430
-
(2013)
Oncol. Rep.
, vol.29
, pp. 2422-2430
-
-
Liang, S.1
Guo, R.2
Zhang, Z.3
Liu, D.4
Xu, H.5
Xu, Z.6
Wang, X.7
Yang, L.8
-
32
-
-
84879316511
-
Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function
-
S. Lim, T.Y. Saw, M. Zhang, M.R. Janes, K. Nacro, J. Hill, A.Q. Lim, C.-T. Chang, D.A. Fruman, and D.A. Rizzieri et al. Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function Proc. Natl. Acad. Sci. USA 110 2013 E2298 E2307
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
-
-
Lim, S.1
Saw, T.Y.2
Zhang, M.3
Janes, M.R.4
Nacro, K.5
Hill, J.6
Lim, A.Q.7
Chang, C.-T.8
Fruman, D.A.9
Rizzieri, D.A.10
-
33
-
-
33745298429
-
Rational design of inhibitors that bind to inactive kinase conformations
-
Y. Liu, and N.S. Gray Rational design of inhibitors that bind to inactive kinase conformations Nat. Chem. Biol. 2 2006 358 364
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 358-364
-
-
Liu, Y.1
Gray, N.S.2
-
34
-
-
84874301754
-
Developing irreversible inhibitors of the protein kinase cysteinome
-
Q. Liu, Y. Sabnis, Z. Zhao, T. Zhang, S.J. Buhrlage, L.H. Jones, and N.S. Gray Developing irreversible inhibitors of the protein kinase cysteinome Chem. Biol. 20 2013 146 159
-
(2013)
Chem. Biol.
, vol.20
, pp. 146-159
-
-
Liu, Q.1
Sabnis, Y.2
Zhao, Z.3
Zhang, T.4
Buhrlage, S.J.5
Jones, L.H.6
Gray, N.S.7
-
35
-
-
2342584183
-
EIF4E - From translation to transformation
-
Y. Mamane, E. Petroulakis, L. Rong, K. Yoshida, L.W. Ler, and N. Sonenberg eIF4E - from translation to transformation Oncogene 23 2004 3172 3179
-
(2004)
Oncogene
, vol.23
, pp. 3172-3179
-
-
Mamane, Y.1
Petroulakis, E.2
Rong, L.3
Yoshida, K.4
Ler, L.W.5
Sonenberg, N.6
-
36
-
-
34250755685
-
Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation
-
Y. Mamane, E. Petroulakis, Y. Martineau, T.-A. Sato, O. Larsson, V.K. Rajasekhar, and N. Sonenberg Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation PLoS ONE 2 2007 e242
-
(2007)
PLoS ONE
, vol.2
, pp. 242
-
-
Mamane, Y.1
Petroulakis, E.2
Martineau, Y.3
Sato, T.-A.4
Larsson, O.5
Rajasekhar, V.K.6
Sonenberg, N.7
-
37
-
-
84885350478
-
Pharmacological targeting of eIF4E in primary CLL lymphocytes
-
V. Martinez-Marignac, M. Shawi, E. Pinedo-Carpio, X. Wang, L. Panasci, W. Miller, F. Pettersson, and R. Aloyz Pharmacological targeting of eIF4E in primary CLL lymphocytes Blood Cancer J. 3 2013 e146
-
(2013)
Blood Cancer J.
, vol.3
, pp. 146
-
-
Martinez-Marignac, V.1
Shawi, M.2
Pinedo-Carpio, E.3
Wang, X.4
Panasci, L.5
Miller, W.6
Pettersson, F.7
Aloyz, R.8
-
38
-
-
80052828293
-
Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells
-
M. Marzec, X. Liu, M. Wysocka, A.H. Rook, N. Odum, and M.A. Wasik Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells PLoS ONE 6 2011 e24849
-
(2011)
PLoS ONE
, vol.6
, pp. 24849
-
-
Marzec, M.1
Liu, X.2
Wysocka, M.3
Rook, A.H.4
Odum, N.5
Wasik, M.A.6
-
39
-
-
84874106479
-
EIF4F suppression in breast cancer affects maintenance and progression
-
Z. Nasr, F. Robert, J.A. Porco Jr., W.J. Muller, and J. Pelletier eIF4F suppression in breast cancer affects maintenance and progression Oncogene 32 2013 861 871
-
(2013)
Oncogene
, vol.32
, pp. 861-871
-
-
Nasr, Z.1
Robert, F.2
Porco Jr., J.A.3
Muller, W.J.4
Pelletier, J.5
-
40
-
-
4444258507
-
Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1
-
A. O'Loghlen, V.M. González, D. Piñeiro, M.I. Pérez-Morgado, M. Salinas, and M.E. Martín Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1 Exp. Cell Res. 299 2004 343 355
-
(2004)
Exp. Cell Res.
, vol.299
, pp. 343-355
-
-
O'Loghlen, A.1
González, V.M.2
Piñeiro, D.3
Pérez-Morgado, M.I.4
Salinas, M.5
Martín, M.E.6
-
41
-
-
25144470125
-
Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin
-
N. Oridate, H.-J. Kim, X. Xu, and R. Lotan Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin Cancer Biol. Ther. 4 2005 318 323
-
(2005)
Cancer Biol. Ther.
, vol.4
, pp. 318-323
-
-
Oridate, N.1
Kim, H.-J.2
Xu, X.3
Lotan, R.4
-
42
-
-
77956741769
-
Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach
-
J. Oyarzabal, N. Zarich, M.I. Albarran, I. Palacios, M. Urbano-Cuadrado, G. Mateos, I. Reymundo, O. Rabal, A. Salgado, and A. Corrionero et al. Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach J. Med. Chem. 53 2010 6618 6628
-
(2010)
J. Med. Chem.
, vol.53
, pp. 6618-6628
-
-
Oyarzabal, J.1
Zarich, N.2
Albarran, M.I.3
Palacios, I.4
Urbano-Cuadrado, M.5
Mateos, G.6
Reymundo, I.7
Rabal, O.8
Salgado, A.9
Corrionero, A.10
-
43
-
-
27844500638
-
Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties
-
J.L. Parra, M. Buxadé, and C.G. Proud Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties J. Biol. Chem. 280 2005 37623 37633
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 37623-37633
-
-
Parra, J.L.1
Buxadé, M.2
Proud, C.G.3
-
44
-
-
0028034233
-
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
-
A. Pause, G.J. Belsham, A.-C. Gingras, O. Donzé, T.-A. Lin, J.C. Lawrence Jr., and N. Sonenberg Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function Nature 371 1994 762 767
-
(1994)
Nature
, vol.371
, pp. 762-767
-
-
Pause, A.1
Belsham, G.J.2
Gingras, A.-C.3
Donzé, O.4
Lin, T.-A.5
Lawrence Jr., J.C.6
Sonenberg, N.7
-
45
-
-
0033521535
-
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E
-
S. Pyronnet, H. Imataka, A.C. Gingras, R. Fukunaga, T. Hunter, and N. Sonenberg Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E EMBO J. 18 1999 270 279
-
(1999)
EMBO J.
, vol.18
, pp. 270-279
-
-
Pyronnet, S.1
Imataka, H.2
Gingras, A.C.3
Fukunaga, R.4
Hunter, T.5
Sonenberg, N.6
-
46
-
-
0023960330
-
Cap recognition and the entry of mRNA into the protein synthesis initiation cycle
-
R.E. Rhoads Cap recognition and the entry of mRNA into the protein synthesis initiation cycle Trends Biochem. Sci. 13 1988 52 56
-
(1988)
Trends Biochem. Sci.
, vol.13
, pp. 52-56
-
-
Rhoads, R.E.1
-
47
-
-
84859845948
-
Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles
-
I.M. Serafimova, M.A. Pufall, S. Krishnan, K. Duda, M.S. Cohen, R.L. Maglathlin, J.M. McFarland, R.M. Miller, M. Frödin, and J. Taunton Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles Nat. Chem. Biol. 8 2012 471 476
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 471-476
-
-
Serafimova, I.M.1
Pufall, M.A.2
Krishnan, S.3
Duda, K.4
Cohen, M.S.5
Maglathlin, R.L.6
McFarland, J.M.7
Miller, R.M.8
Frödin, M.9
Taunton, J.10
-
48
-
-
31544450787
-
Novel procedure for modeling ligand/receptor induced fit effects
-
W. Sherman, T. Day, M.P. Jacobson, R.A. Friesner, and R. Farid Novel procedure for modeling ligand/receptor induced fit effects J. Med. Chem. 49 2006 534 553
-
(2006)
J. Med. Chem.
, vol.49
, pp. 534-553
-
-
Sherman, W.1
Day, T.2
Jacobson, M.P.3
Friesner, R.A.4
Farid, R.5
-
49
-
-
77957852191
-
Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction
-
M. Shveygert, C. Kaiser, S.S. Bradrick, and M. Gromeier Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction Mol. Cell. Biol. 30 2010 5160 5167
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 5160-5167
-
-
Shveygert, M.1
Kaiser, C.2
Bradrick, S.S.3
Gromeier, M.4
-
50
-
-
41849138637
-
MNK, EIF4E and targeting translation for therapy
-
R.L.A. Silva, and H.G. Wendel MNK, EIF4E and targeting translation for therapy Cell Cycle 7 2008 553 555
-
(2008)
Cell Cycle
, vol.7
, pp. 553-555
-
-
Silva, R.L.A.1
Wendel, H.G.2
-
52
-
-
0034306706
-
Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor β
-
K. Slentz-Kesler, J.T. Moore, M. Lombard, J. Zhang, R. Hollingsworth, and M.P. Weiner Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor β Genomics 69 2000 63 71
-
(2000)
Genomics
, vol.69
, pp. 63-71
-
-
Slentz-Kesler, K.1
Moore, J.T.2
Lombard, M.3
Zhang, J.4
Hollingsworth, R.5
Weiner, M.P.6
-
53
-
-
79551594605
-
Protein kinases: Evolution of dynamic regulatory proteins
-
S.S. Taylor, and A.P. Kornev Protein kinases: evolution of dynamic regulatory proteins Trends Biochem. Sci. 36 2011 65 77
-
(2011)
Trends Biochem. Sci.
, vol.36
, pp. 65-77
-
-
Taylor, S.S.1
Kornev, A.P.2
-
54
-
-
3242719457
-
Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development
-
T. Ueda, R. Watanabe-Fukunaga, H. Fukuyama, S. Nagata, and R. Fukunaga Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development Mol. Cell. Biol. 24 2004 6539 6549
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 6539-6549
-
-
Ueda, T.1
Watanabe-Fukunaga, R.2
Fukuyama, H.3
Nagata, S.4
Fukunaga, R.5
-
55
-
-
77956271160
-
Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development
-
T. Ueda, M. Sasaki, A.J. Elia, I.I.C. Chio, K. Hamada, R. Fukunaga, and T.W. Mak Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development Proc. Natl. Acad. Sci. USA 107 2010 13984 13990
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 13984-13990
-
-
Ueda, T.1
Sasaki, M.2
Elia, A.J.3
Chio, I.I.C.4
Hamada, K.5
Fukunaga, R.6
Mak, T.W.7
-
56
-
-
0030977269
-
Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
-
A.J. Waskiewicz, A. Flynn, C.G. Proud, and J.A. Cooper Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 EMBO J. 16 1997 1909 1920
-
(1997)
EMBO J.
, vol.16
, pp. 1909-1920
-
-
Waskiewicz, A.J.1
Flynn, A.2
Proud, C.G.3
Cooper, J.A.4
-
57
-
-
37249042829
-
Dissecting eIF4E action in tumorigenesis
-
H.G. Wendel, R.L.A. Silva, A. Malina, J.R. Mills, H. Zhu, T. Ueda, R. Watanabe-Fukunaga, R. Fukunaga, J. Teruya-Feldstein, J. Pelletier, and S.W. Lowe Dissecting eIF4E action in tumorigenesis Genes Dev. 21 2007 3232 3237
-
(2007)
Genes Dev.
, vol.21
, pp. 3232-3237
-
-
Wendel, H.G.1
Silva, R.L.A.2
Malina, A.3
Mills, J.R.4
Zhu, H.5
Ueda, T.6
Watanabe-Fukunaga, R.7
Fukunaga, R.8
Teruya-Feldstein, J.9
Pelletier, J.10
Lowe, S.W.11
-
58
-
-
77957596297
-
The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival
-
M.J. Wheater, P.W.M. Johnson, and J.P. Blaydes The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival Cancer Biol. Ther. 10 2010 728 735
-
(2010)
Cancer Biol. Ther.
, vol.10
, pp. 728-735
-
-
Wheater, M.J.1
Johnson, P.W.M.2
Blaydes, J.P.3
-
59
-
-
84871570209
-
EIF4E over-expresses and enhances cell proliferation and cell cycle progression in nasopharyngeal carcinoma
-
M. Wu, Y. Liu, X. Di, H. Kang, H. Zeng, Y. Zhao, K. Cai, T. Pang, S. Wang, Y. Yao, and X. Hu EIF4E over-expresses and enhances cell proliferation and cell cycle progression in nasopharyngeal carcinoma Med. Oncol. 30 2013 400
-
(2013)
Med. Oncol.
, vol.30
, pp. 400
-
-
Wu, M.1
Liu, Y.2
Di, X.3
Kang, H.4
Zeng, H.5
Zhao, Y.6
Cai, K.7
Pang, T.8
Wang, S.9
Yao, Y.10
Hu, X.11
-
60
-
-
84882948239
-
Rational design of resorcylic acid lactone analogues as covalent MNK1/2 kinase inhibitors by tuning the reactivity of an enamide Michael acceptor
-
J. Xu, A. Chen, J. Joy, V.J. Xavier, E.H. Ong, J. Hill, and C.L. Chai Rational design of resorcylic acid lactone analogues as covalent MNK1/2 kinase inhibitors by tuning the reactivity of an enamide Michael acceptor ChemMedChem 8 2013 1483 1494
-
(2013)
ChemMedChem
, vol.8
, pp. 1483-1494
-
-
Xu, J.1
Chen, A.2
Joy, J.3
Xavier, V.J.4
Ong, E.H.5
Hill, J.6
Chai, C.L.7
-
61
-
-
84876704953
-
Inhibition of S6 kinase suppresses the apoptotic effect of eIF4E ablation by inducing TGF-β-dependent G1 cell cycle arrest
-
P. Yellen, A. Chatterjee, A. Preda, and D.A. Foster Inhibition of S6 kinase suppresses the apoptotic effect of eIF4E ablation by inducing TGF-β-dependent G1 cell cycle arrest Cancer Lett. 333 2013 239 243
-
(2013)
Cancer Lett.
, vol.333
, pp. 239-243
-
-
Yellen, P.1
Chatterjee, A.2
Preda, A.3
Foster, D.A.4
-
62
-
-
53549085163
-
Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance
-
M. Zhang, W. Fu, S. Prabhu, J.C. Moore, J. Ko, J.W. Kim, B.J. Druker, V. Trapp, J. Fruehauf, and H. Gram et al. Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance Mol. Cell. Biol. 28 2008 6496 6509
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 6496-6509
-
-
Zhang, M.1
Fu, W.2
Prabhu, S.3
Moore, J.C.4
Ko, J.5
Kim, J.W.6
Druker, B.J.7
Trapp, V.8
Fruehauf, J.9
Gram, H.10
-
63
-
-
57749188299
-
Targeting cancer with small molecule kinase inhibitors
-
J. Zhang, P.L. Yang, and N.S. Gray Targeting cancer with small molecule kinase inhibitors Nat. Rev. Cancer 9 2009 28 39
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 28-39
-
-
Zhang, J.1
Yang, P.L.2
Gray, N.S.3
-
64
-
-
79959236276
-
Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells
-
F.F. Zhou, M. Yan, G.F. Guo, F. Wang, H.J. Qiu, F.M. Zheng, Y. Zhang, Q. Liu, X.F. Zhu, and L.P. Xia Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells Med. Oncol. 28 2011 1302 1307
-
(2011)
Med. Oncol.
, vol.28
, pp. 1302-1307
-
-
Zhou, F.F.1
Yan, M.2
Guo, G.F.3
Wang, F.4
Qiu, H.J.5
Zheng, F.M.6
Zhang, Y.7
Liu, Q.8
Zhu, X.F.9
Xia, L.P.10
-
65
-
-
77950573400
-
Through the "gatekeeper door": Exploiting the active kinase conformation
-
F. Zuccotto, E. Ardini, E. Casale, and M. Angiolini Through the "gatekeeper door": exploiting the active kinase conformation J. Med. Chem. 53 2010 2681 2694
-
(2010)
J. Med. Chem.
, vol.53
, pp. 2681-2694
-
-
Zuccotto, F.1
Ardini, E.2
Casale, E.3
Angiolini, M.4
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