Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction

Molecular and Cellular Biology

Volumn 30, Issue 21, 2010, Pages 5160-5167

  Shveygert, Mayya ^a   Kaiser, Constanze ^a,b   Bradrick, Shelton S ^a   Gromeier, Matthias ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 4E; INITIATION FACTOR 4G; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN MNK 1; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; MKNK1 PROTEIN, HUMAN; MKNK1 PROTEIN, MOUSE; MKNK2 PROTEIN, MOUSE; PRIMER DNA; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; SIGNAL PEPTIDE;

ANIMAL CELL; ARTICLE; AUTOREGULATION; CARBOXY TERMINAL SEQUENCE; CATALYSIS; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; DEFICIENCY; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION;

EUKARYOTA;

ANIMALS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; EUKARYOTIC INITIATION FACTOR-4E; EUKARYOTIC INITIATION FACTOR-4G; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS;

EID: 77957852191     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00448-10     Document Type: Article

References (23)

1. Bradrick, S. S., and M. Gromeier. 2009. Identification of gemin5 as a novel 7-methylguanosine cap-binding protein. PLoS One 4:e7030.
2. Fukunaga, R., and T. Hunter. 1997. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J. 16:1921-1933. (Pubitemid 27170953)
3. Furic, L., L. Rong, O. Larsson, I. H. Koumakpayi, K. Yoshida, A. Brueschke, E. Petroulakis, N. Robichaud, M. Pollak, L. A. Gaboury, P. P. Pandolfi, F. Saad, and N. Sonenberg. 2010. eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc. Natl. Acad. Sci. U. S. A. 107:14134-14139.
4. Gingras, A. C., B. Raught, and N. Sonenberg. 1999. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68:913-963.
5. Goto, S., Z. Yao, and C. G. Proud. 2009. The C-terminal domain of Mnk1a plays a dual role in tightly regulating its activity. Biochem. J. 423:279-290.
6. Jauch, R., M. K. Cho, S. Jakel, C. Netter, K. Schreiter, B. Aicher, M. Zweckstetter, H. Jackle, and M. C. Wahl. 2006. Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment. EMBO J. 25:4020-4032.
7. Kaiser, C., E. Y. Dobrikova, S. S. Bradrick, M. Shveygert, J. T. Herbert, and M. Gromeier. 2008. Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo. RNA 14:2170-2182.
8. Knauf, U., C. Tschopp, and H. Gram. 2001. Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. Mol. Cell. Biol. 21:5500-5511.
9. Lazaris-Karatzas, A., K. S. Montine, and N. Sonenberg. 1990. Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap. Nature 345:544-547. (Pubitemid 20178912)
10. Mamane, Y., E. Petroulakis, L. Rong, K. Yoshida, L. W. Ler, and N. Sonenberg. 2004. eIF4E-from translation to transformation. Oncogene 23:3172-3179.
11. O'Loghlen, A., V. M. Gonzalez, D. Pineiro, M. I. Perez-Morgado, M. Salinas, and M. E. Martin. 2004. Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1. Exp. Cell Res. 299:343-355.
12. Orton, K. C., J. Ling, A. J. Waskiewicz, J. A. Cooper, W. C. Merrick, N. L. Korneeva, R. E. Rhoads, N. Sonenberg, and J. A. Traugh. 2004. Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. J. Biol. Chem. 279:38649-38657.
13. Pyronnet, S. 2000. Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1. Biochem. Pharmacol. 60:1237-1243.
14. Pyronnet, S., H. Imataka, A. C. Gingras, R. Fukunaga, T. Hunter, and N. Sonenberg. 1999. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J. 18:270-279. (Pubitemid 29005042)
15. Rajasekhar, V. K., A. Viale, N. D. Socci, M. Wiedmann, X. Hu, and E. C. Holland. 2003. Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol. Cell 12:889-901.
16. Raught, B., A. C. Gingras, S. P. Gygi, H. Imataka, S. Morino, A. Gradi, R. Aebersold, and N. Sonenberg. 2000. Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J. 19:434-444. (Pubitemid 30072613)
17. Scheper, G. C., N. A. Morrice, M. Kleijn, and C. G. Proud. 2001. The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. Mol. Cell. Biol. 21:743-754.
18. Scheper, G. C., J. L. Parra, M. Wilson, B. Van Kollenburg, A. C. Vertegaal, Z. G. Han, and C. G. Proud. 2003. The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization. Mol. Cell. Biol. 23:5692-5705.
19. Scheper, G. C., and C. G. Proud. 2002. Does phosphorylation of the capbinding protein eIF4E play a role in translation initiation? Eur. J. Biochem. 269:5350-5359.
20. Ueda, T., M. Sasaki, A. J. Elia, I. I. Chio, K. Hamada, R. Fukunaga, and T. W. Mak. 2010. Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proc. Natl. Acad. Sci. U. S. A. 107:13984-13990.
21. Ueda, T., R. Watanabe-Fukunaga, H. Fukuyama, S. Nagata, and R. Fukunaga. 2004. Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol. Cell. Biol. 24:6539-6549.
22. Waskiewicz, A. J., A. Flynn, C. G. Proud, and J. A. Cooper. 1997. Mitogenactivated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 16:1909-1920.
23. Wendel, H. G., R. L. Silva, A. Malina, J. R. Mills, H. Zhu, T. Ueda, R. Watanabe-Fukunaga, R. Fukunaga, J. Teruya-Feldstein, J. Pelletier, and S. W. Lowe. 2007. Dissecting eIF4E action in tumorigenesis. Genes Dev. 21:3232-3237.