Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site

Structure

Volumn 13, Issue 10, 2005, Pages 1559-1568

  Jauch, Ralf ^a   Jäkel, Stefan ^b   Netter, Catharina ^a   Schreiter, Kay ^b   Aicher, Babette ^b   Jäckle, Herbert ^a   Wahl, Markus C ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b DeveloGen AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID DERIVATIVE; ASPARTIC ACID DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE INTERACTING PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE P38; PHENYLALANINE; PHENYLALANINE DERIVATIVE; PROTEIN; UNCLASSIFIED DRUG; ZINC;

ARTICLE; BINDING SITE; CONFORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF;

ADENOSINE TRIPHOSPHATE; ALTERNATIVE SPLICING; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CHROMATOGRAPHY, GEL; CRYSTALLOGRAPHY, X-RAY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGHT; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHENYLALANINE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; SCATTERING, RADIATION; SEQUENCE HOMOLOGY, AMINO ACID; SPECTRUM ANALYSIS, RAMAN; ZINC;

EUKARYOTA;

EID: 26444592983     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.str.2005.07.013     Document Type: Article

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