Role of Notch signalling pathway in cancer and its association with DNA methylation

Journal of Genetics

Volumn 92, Issue 3, 2013, Pages 667-675

  Aithal, Madhuri G S ^a   Rajeswari, Narayanappa ^a  

^a DAYANANDA SAGAR COLLEGE OF ENGINEERING   (India)

Author keywords

biomarker; cancer; epigenetics; methylation; Notch signalling pathway

Indexed keywords

ANTINEOPLASTIC AGENT; NOTCH RECEPTOR;

ANIMAL; ARTICLE; CPG ISLAND; DNA METHYLATION; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETICS; HUMAN; METABOLISM; NEOPLASM; ONCOGENE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTINEOPLASTIC AGENTS; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; GENETIC PREDISPOSITION TO DISEASE; HUMANS; NEOPLASMS; ONCOGENES; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 84899564826     PISSN: 00221333     EISSN: 09737731     Source Type: Journal    
DOI: 10.1007/s12041-013-0284-5     Document Type: Article

References (78)

1. Agrawal N., Frederick M. J., Pickering C. R., Bettegowda C., Chang K., Li R. J. et al. 2011 Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science333, 1154-1157.
2. Aktas S., Zadeo{eth}lulari Z., Erçetin P. and Olgun N. 2010 The effect of differentiating and apoptotic agents on Notch signalling pathway in hepatoblastoma. Hepatogastroenterology57, 891-898.
3. Aster J. C., Blacklow S. C. and Pear W. S. 2011 Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. J. Pathol. 223, 262-273.
4. Baylin S. B., Esteller M., Rountree M. R., Bachman K. E., Schuebel K. and Herman J. G. 2001 Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum. Mol. Genet. 10, 687-692.
5. Brou C., Logeat F., Gupta N., Bessia C., LeBail O., Doedens J. R. et al. 2000 A novel proteolytic cleavage involved in notch signaling: the role of the disintegrin-metalloprotease TACE. Mol. Cell. 5, 207-216.
6. Chen J., Kesari S., Rooney C., Strack P. R., Chen J., Shen H. et al. 2010 Inhibition of Notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. Genes Cancer1, 822-835.
7. Chigurupati S., Venkataraman R., Barrera D., Naganathan A., Madan M., Paul L. et al. 2010 Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness. Cancer Res. 70, 418-427.
8. Choi J. H., Park J. T., Davidson B., Morin P. J., Shih IeM. and Wang T. L. 2008 Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion. Cancer Res. 68, 5716-5723.
9. Chu D., Zheng J., Wang W., Zhao Q., Li Y., Li J. et al. 2009 Notch2 expression is decreased in colorectal cancer and related to tumor differentiation status. Ann. Surg. Oncol. 16, 3259-3266.
10. Cohen B., Shimizu M., Izrailit J., Ng N. F., Buchman Y., Pan J. G. et al. 2010 Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer. Breast Cancer Res. Treat. 123, 113-124.
11. Das P. M. and Singal R. 2004 DNA methylation and cancer. J. Clin. Oncol. 22, 4632-4642.
12. Dotto G. P. 2008 Notch tumor suppressor function. Oncogene27, 5115-5123.
13. Fabbri M., Garzon R., Cimmino A., Liu Z., Zanesi N., Callegari E. et al. 2007 MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc. Natl. Acad. Sci. USA104, 15805-15810.
14. Fan X., Mikolaenko I., Elhassan I., Ni X., Wang Y., Ball D. et al. 2004 Notch1 and Notch2 have opposite effects on embryonal brain tumor growth. Cancer Res. 64, 7787-7793.
15. Fan X., Khaki L., Zhu T. S., Soules M. E., Talsma C. E., Gul N. et al. 2010 NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells28, 5-16.
16. Fang M., Chen D. and Yang C. S. 2007 Dietary polyphenols may affect DNA methylation. J. Nutr. 137, 223S-228S.
17. INK4a, RARâ, and MGMT genes by genistein and other isoflavones from soy. Clin. Cancer Res. 11, 7033-7041.
18. Ferretti E., Tosi E., Po A., Scipioni A., Morisi R., Espinola M. S. et al. 2008 Notch signaling is involved in expression of thyrocyte differentiation markers and is down-regulated in thyroid tumors. J. Clin. Endocrinol. Metab. 93, 4080-4087.
19. Franko-Tobin L. G., Mackey L. V., Huang W., Song X., Jin B., Luo J. et al. 2012 Notch1-mediated tumor suppression in cervical cancer with the involvement of SST signaling and its application in enhanced SSTR-targeted therapeutics. Oncologist17, 220-232.
20. Ghoshal P., Nganga A. J., Moran-Giuati J., Szafranek A., Johnson T. R., Bigelow A. J. et al. 2009 Loss of the SMRT/NCoR2 corepressor correlates with JAG2 overexpression in multiple myeloma. Cancer Res. 69, 4380-4387.
21. Gu J. W., Rizzo P., Pannuti A., Golde T., Osborne B. and Miele L. 2012 Notch signals in the endothelium and cancer "stem-like" cells: Opportunities for cancer therapy. Vascular Cell4, 1-9.
22. Harrison H., Farnie G., Howell S. J., Rock R. E., Stylianou S., Brennan K. R. et al. 2010 Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res. 70, 709-718.
23. Hellebrekers D. M., Jair K. W., Viré E., Eguchi S., Hoebers N. T., Fraga M. F. et al. 2006 Angiostatic activity of DNA methyltransferase inhibitors. Mol. Cancer Ther. 5, 467-475.
24. Hernandez-Vargas H., Lambert M. P., Le Calvez-Kelm F., Gouysse G., McKay-Chopin S., Tavtigian S. V. et al. 2010 Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors. PLoS ONE5, e9749.
25. Houde C., Li Y., Song L., Barton K., Zhang Q., Godwin J. et al. 2004 Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines. Blood104, 3697-3704.
26. Hsu K. W., Hsieh R. H., Huang K. H., Fen-Yau Li A., Chi C. W., Wang T. Y. et al. 2012 Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression. Carcinogenesis33, 1459-1467.
27. Hu W., Lu C., Dong H. H., Huang J., Shen D. Y., Stone R. L. et al. 2011 Biological roles of the Delta family Notch ligand Dll4 in tumor and endothelial cells in ovarian cancer. Cancer Res. 71, 6030-6039.
28. Ilagan M. X. and Kopan R. 2007 SnapShot: Notch signaling pathway. Cell128, 1246.
29. Iwai A., Takegami T., Shiozaki T. and Miyazaki T. 2011 Hepatitis C Virus NS3 protein can activate the notch-signaling pathway through binding to a transcription factor, SRCAP. PLoS ONE6, e20718.
30. Jubb A. M., Turley H., Moeller H. C., Steers G., Han C., Li J. L. et al. 2009 Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer. Br. J. Cancer101, 1749-1757.
31. Jubb A. M., Soilleux E. J., Turley H., Steers G., Parker A., Low I. et al. 2010 Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer. Am. J. Pathol. 176, 2019-2028.
32. Kim H. A., Koo B. K., Cho J. H., Kim Y. Y., Seong J., Chang H. J. et al. 2012 Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer. J. Clin. Invest. 122, 3248-3259.
33. Klinakis A., Lobry C., Abdel-Wahab O., Oh P., Haeno H., Buonamici S. et al. 2011 A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature473, 230-233.
34. Kopan R. 2002 Notch: a membrane-bound transcription factor. J. Cell Sci. 115, 1095-1097.
35. Kuhnert F., Kirshner J. R. and Thurston G. 2011 Dll4-Notch signaling as a therapeutic target in tumor angiogenesis. Vasc. Cell3, 20.
36. Kunnimalaiyaan M. and Chen H. 2007 Tumor suppressor role of notch-1 signaling in neuroendocrine tumors. The Oncologist12, 535-542.
37. Kunnimalaiyaan M., Traeger K. and Chen H. 2005 Conservation of the Notch1 signaling pathway in gastrointestinal carcinoid cells. Am. J. Physiol. Gastrointest. Liver Physiol. 289, 636-642.
38. Kunnimalaiyaan M., Vaccaro A. M., Ndiaye M. A. and Chen H. 2006 Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. J. Biol. Chem. 281, 39819-39830.
39. ′-deoxycytidine. Cancer Res. 62, 961-966.
40. Luo J., Li Y. N., Wang F., Zhang W. M. and Geng X. 2010 S-Adenosylmethionine inhibits the growth of cancer cells by reversing the hypomethylation status of c-myc and H-ras in human gastric cancer and colon cancer. Int. J. Biol. Sci. 6, 784-795.
41. McAuliffe S. M., Morgan S. L., Wyant G. A., Tran L. T., Muto K. W., Chen Y. S. et al. 2012 Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy. Proc. Natl. Acad. Sci. USA109, 2939-2948.
42. Meng R. D., Shelton C. C., Li Y. M., Qin L. X., Notterman D., Paty P. B. et al. 2009 γ-Secretase inhibitors abrogate oxaliplatin-induced activation of the notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res. 69, 573-582.
43. Mittal S., Subramanyam D., Dey D., Kumar R. V. and Rangarajan A. 2009 Cooperation of notch and Ras/MAPK signaling pathways in human breast carcinogenesis. Mol. Cancer8, 128.
44. Morgan T. H. 1917 The theory of the gene. Am. Nat. 51, 513-544.
45. ′-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists. BMC Cancer10, 366.
46. Nicolas M., Wolfer A., Raj K., Kummer J. A., Mill P., van Noort M. et al. 2003 Notch1 functions as a tumor suppressor in mouse skin. Nat. Genet. 33, 416-421.
47. Osanyingbemi-Obidi J., Dobromilskaya I., Illei P. B., Hann C. L. and Rudin C. M. 2011 Notch signaling contributes to lung cancer clonogenic capacity in vitro but may be circumvented in tumorigenesis in vivo. Mol. Cancer Res. 9, 1746-1754.
48. Parr C., Watkins G. and Jiang W. G. 2004 The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer. Int. J. Mol. Med. 14, 779-786.
49. Piazzi G., Fini L., Selgrad M., Garcia M., Daoud Y., Wex T. et al. 2011 Epigenetic regulation of delta-like1 controls Notch1 activation in gastric cancer. Oncotarget2, 1291-1301.
50. Qi R., An H., Yu Y., Zhang M., Liu S., Xu H. et al. 2003 Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. Cancer Res. 63, 8323-8329.
51. Rao S. S., O'Neil J., Liberator C. D., Hardwick J. S., Dai X., Zhang T. et al. 2009 Winter inhibition of notch signaling by gamma secretase inhibitor engages the rb pathway and elicits cell cycle exit in t-cell acute lymphoblastic leukemia cells. Cancer Res. 69, 3060-3068.
52. Razin A. and Cedar H. 1991 DNA methylation and gene expression. Microbiol. Rev. 55, 451-458.
53. Reedijk M., Odorcic S., Zhang H., Chetty R., Tennert C., Dickson B. C. et al. 2008 Activation of Notch signaling in human colon adenocarcinoma. Int. J. Oncol. 33, 1223-1229.
54. Ren M. and Cowell J. K. 2011 Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease. Blood117, 6837-6847.
55. Rodilla V., Villanueva A., Obrador-Hevia A., Robert-Moreno A., Fernández-Majada V., Grilli A. et al. 2009 Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc. Natl. Acad. Sci. USA106, 6315-6320.
56. Rose S. L., Kunnimalaiyaan M., Drenzek J. and Seiler N. 2010 Notch 1 signaling is active in ovarian cancer. Gynecol. Oncol. 117, 130-133.
57. Serafin V., Persano L., Moserle L., Esposito G., Ghisi M., Curtarello M. et al. 2011 Notch3 signalling promotes tumour growth in colorectal cancer. J. Pathol. 224, 448-460.
58. Shih IeM. and Wang T. L. 2007 Notch signaling, gamma-secretase inhibitors, and cancer therapy. Cancer Res. 67, 1879-1882.
59. Shou J., Ross S., Koeppen H., de Sauvage F. J. and Gao W. Q. 2001 Dynamics of Notch expression during murine prostate development and tumorigenesis. Cancer Res. 61, 7291-7297.
60. Sriuranpong V., Borges M. W., Ravi R. K., Arnold D. R., Nelkin B. D., Baylin S. B. et al. 2001 Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res. 61, 3200-3205.
61. Steg A. D., Katre A. A., Goodman B., Han H. D., Nick A. M., Stone R. L. et al. 2011 Targeting the notch ligand JAGGED1 in both tumor cells and stroma in ovarian cancer. Clin. Cancer Res. 17, 5674-5685.
62. Stransky N., Egloff A. M., Tward A. D., Kostic A. D., Cibulskis K., Sivachenko A. et al. 2011 The mutational landscape of head and neck squamous cell carcinoma. Science333, 1157-1160.
63. Sun Y., Gao X., Liu J., Kong Q. Y., Wang X. W., Chen X. Y. et al. 2011 Differential Notch1 and Notch2 expression and frequent activation of Notch signaling in gastric cancers. Arch. Pathol. Lab. Med. 135, 451-458.
64. Talora C., Sgroi D. C., Crum C. P. and Dotto G. P. 2002 Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev. 16, 2252-2263.
65. Tohda S., Murata-Ohsawa M., Sakano S. and Nara N. 2003 Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines. Int. J. Oncol. 22, 1073-1079.
66. Tseng Y. C., Tsai Y. H., Tseng M. J., Hsu K. W., Yang M. C., Huang K. H. et al. 2012 Notch2-induced COX-2 expression enhancing gastric cancer progression. Mol. Carcinog. 51, 939-951.
67. Viatour P., Ehmer U., Saddic L. A., Dorrell C., Andersen J. B., Lin C. et al. 2011 Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J. Exp. Med. 208, 1963-1976.
68. Vo K., Amarasinghe B., Washington K., Gonzalez A., Berlin J. and Dang T. P. 2011 Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation. Mol. Cancer10, 138.
69. Wu L., Sun T., Kobayashi K., Gao P. and Griffin J. D. 2002 Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol. Cell Biol. 22, 7688-7700.
70. Yamaguchi N., Oyama T., Ito E., Satoh H., Azuma S., Hayashi M. et al. 2008 NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells. Cancer Res. 68, 1881-1888.
71. Ye Q. F., Zhang Y. C., Peng X. Q., Long Z., Ming Y. Z. and He L. Y. 2012 Silencing Notch-1 induces apoptosis and increases the chemosensitivity of prostate cancer cells to docetaxel through Bcl-2 and Bax. Oncol. Lett. 3, 879-884.
72. Yeasmin S., Nakayama K., Rahman M. T., Rahman M., Ishikawa M., Iida K. et al. 2010 Expression of nuclear Notch3 in cervical squamous cell carcinomas and its association with adverse clinical outcomes. Gynecol. Oncol. 117, 409-416.
73. Yeh T. S., Wu C. W., Hsu K. W., Liao W. J., Yang M. C., Li A. F. et al. 2009 The activated Notch1 signal pathway is associated with gastric cancer progression through cyclooxygenase-2. Cancer Res. 69, 5039-5048.
74. Zardawi S. J., Zardawi I., McNeil C. M., Millar E. K., McLeod D., Morey A. L. et al. 2010 High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype. Histopathology56, 286-296.
75. Zhang Y., Wang Z., Ahmed F., Banerjee S., Li Y. and Sarkar F. H. 2006 Down-regulation of Jagged-1 induces cell growth inhibition and S phase arrest in prostate cancer cells. Int. J. Cancer119, 2071-2077.
76. Zhang Y., Li B., Ji Z. Z. and Zheng P. S. 2010 Notch1 regulates the growth of human colon cancers. Cancer116, 5207- 5218.
77. Zhao N., Guo Y., Zhang M., Lin L. and Zheng Z. 2010 Akt-mTOR signaling is involved in Notch-1-mediated glioma cell survival and proliferation. Oncol. Rep. 23, 1443-1447.
78. Zweidler-McKay P. A., He Y., Xu L., Rodriguez C. G., Karnell F. G., Carpenter A. C. et al. 2005 Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies. Blood106, 3898-3906.