Notch signaling contributes to lung cancer clonogenic capacity in vitro but may be circumvented in tumorigenesis in vivo

Molecular Cancer Research

Volumn 9, Issue 12, 2011, Pages 1746-1754

  Osanyingbemi Obidi, Joyce ^a   Dobromilskaya, Irina ^a   Illei, Peter B ^b   Hann, Christine L ^a   Rudin, Charles M ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOMINANT NEGATIVE MASTERMIND LIKE PROTEIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; GLYCINE; K RAS PROTEIN; MEMBRANE RECEPTOR; MRK 003; NOTCH INTRACELLULAR DOMAIN 3; NOTCH RECEPTOR; NOTCH3 RECEPTOR; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL PROLIFERATION; CLONOGENESIS; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG CARCINOGENESIS; LUNG LESION; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COLONY-FORMING UNITS ASSAY; CYCLIC S-OXIDES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOPLASMS, EXPERIMENTAL; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; THIADIAZOLES;

EID: 84055207485     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-11-0286     Document Type: Article

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