Expression of nuclear Notch3 in cervical squamous cell carcinomas and its association with adverse clinical outcomes

Gynecologic Oncology

Volumn 117, Issue 3, 2010, Pages 409-416

  Yeasmin, Shamima ^a   Nakayama, Kentaro ^a   Rahman, Mohammed Tanjimur ^a   Rahman, Munmun ^a   Ishikawa, Masako ^a   Iida, Kouji ^a   Otsuki, Yoshiro ^b   Kobayashi, Hiroshi ^b   Nakayama, Satoru ^b   Miyazaki, Kohji ^a  

^a SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

^b SEIREI HAMAMATSU GENERAL HOSPITAL   (Japan)

Author keywords

secretase inhibitor; Cervical carcinoma; Jagged 1; Notch3; Pbx1b; Prognosis

Indexed keywords

GAMMA SECRETASE INHIBITOR; JAGGED1; NOTCH3 RECEPTOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR PBX1; TRANSCRIPTION FACTOR PBX1B; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER SURVIVAL; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA DETERMINATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE ACTIVATION; GENE AMPLIFICATION; GENE DUPLICATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SIGNAL TRANSDUCTION; UTERINE CERVIX; UTERINE CERVIX CARCINOMA;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CALCIUM-BINDING PROTEINS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CERVICAL INTRAEPITHELIAL NEOPLASIA; DNA COPY NUMBER VARIATIONS; DNA-BINDING PROTEINS; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS; RECEPTORS, NOTCH; RETROSPECTIVE STUDIES; RNA, SMALL INTERFERING; TREATMENT OUTCOME; UTERINE CERVICAL NEOPLASMS;

EID: 77951938442     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2010.03.004     Document Type: Article

References (29)

1. Jones S.B. Cancer in the developing world: a call to action. Bmj 319 (1999) 505-508
2. zur Hausen H. Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis. J Natl Cancer Inst 92 (2000) 690-698
3. Schwab M. Oncogene amplification in solid tumors. Semin Cancer Biol 9 (1999) 319-325
4. Hale R.J., Buckley C.H., Gullick W.J., Fox H., Williams J., and Wilcox F.L. Prognostic value of epidermal growth factor receptor expression in cervical carcinoma. J Clin Pathol 46 (1993) 149-153
5. Imoto I., Tsuda H., Hirasawa A., Miura M., Sakamoto M., Hirohashi S., and Inazawa J. Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. Cancer Res 62 (2002) 4860-4866
6. Kurzrock R., Ku S., and Talpaz M. Abnormalities in the PRAD1 (CYCLIN D1/BCL-1) oncogene are frequent in cervical and vulvar squamous cell carcinoma cell lines. Cancer 75 (1995) 584-590
7. Mitra A.B., Murty V.V., Pratap M., Sodhani P., and Chaganti R.S. ERBB2 (HER2/neu) oncogene is frequently amplified in squamous cell carcinoma of the uterine cervix. Cancer Res 54 (1994) 637-639
8. Ocadiz R., Sauceda R., Cruz M., Graef A.M., and Gariglio P. High correlation between molecular alterations of the c-myc oncogene and carcinoma of the uterine cervix. Cancer Res 47 (1987) 4173-4177
9. Pfeiffer D., Stellwag B., Pfeiffer A., Borlinghaus P., Meier W., and Scheidel P. Clinical implications of the epidermal growth factor receptor in the squamous cell carcinoma of the uterine cervix. Gynecol Oncol 33 (1989) 146-150
10. Park J.T., Li M., Nakayama K., Mao T.L., Davidson B., Zhang Z., Kurman R.J., Eberhart C.G., Shih Ie M., and Wang T.L. Notch3 gene amplification in ovarian cancer. Cancer Res 66 (2006) 6312-6318
11. Konishi J., Kawaguchi K.S., Vo H., Haruki N., Gonzalez A., Carbone D.P., and Dang T.P. Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. Cancer Res 67 (2007) 8051-8057
12. Yamaguchi N., Oyama T., Ito E., Satoh H., Azuma S., Hayashi M., Shimizu K., Honma R., Yanagisawa Y., Nishikawa A., Kawamura M., Imai J., Ohwada S., Tatsuta K., Inoue J., Semba K., and Watanabe S. NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells. Cancer Res 68 (2008) 1881-1888
13. Gallahan D., and Callahan R. The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Oncogene 14 (1997) 1883-1890
14. Grabher C., von Boehmer H., and Look A.T. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer 6 (2006) 347-359
15. Maliekal T.T., Bajaj J., Giri V., Subramanyam D., and Krishna S. The role of Notch signaling in human cervical cancer: implications for solid tumors. Oncogene 27 (2008) 5110-5114
16. Veeraraghavalu K., Pett M., Kumar R.V., Nair P., Rangarajan A., Stanley M.A., and Krishna S. Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation. J Virol. 78 (2004) 8687-8700
17. Weijzen S., Zlobin A., Braid M., Miele L., and Kast W.M. HPV16 E6 and E7 oncoproteins regulate Notch-1 expression and cooperate to induce transformation. J Cell Physiol 194 (2003) 356-362
18. Shepherd J.H. Cervical and vulva cancer: changes in FIGO definitions of staging. Br J Obstet Gynaecol 103 (1996) 405-406
19. United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR). Guidelines for the welfare of animals in experimental neoplasia (second edition). Br J Cancer 77 (1998) 1-10
20. Choi J.H., Park J.T., Davidson B., Morin P.J., Shih Ie M., and Wang T.L. Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion. Cancer Res 68 (2008) 5716-5723
21. Park J.T., Shih Ie M., and Wang T.L. Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer. Cancer Res 68 (2008) 8852-8860
22. Curry C.L., Reed L.L., Golde T.E., Miele L., Nickoloff B.J., and Foreman K.E. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene 24 (2005) 6333-6344
23. van Es J.H., van Gijn M.E., Riccio O., van den Born M., Vooijs M., Begthel H., Cozijnsen M., Robine S., Winton D.J., Radtke F., and Clevers H. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435 (2005) 959-963
24. Contag S.A., Gostout B.S., Clayton A.C., Dixon M.H., McGovern R.M., and Calhoun E.S. Comparison of gene expression in squamous cell carcinoma and adenocarcinoma of the uterine cervix. Gynecol Oncol 95 (2004) 610-617
25. Yeasmin S., Nakayama K., Ishibashi M., Katagiri A., Iida K., Purwana I.N., Nakayama N., and Miyazaki K. Expression of the bric-a-brac tramtrack broad complex protein NAC-1 in cervical carcinomas seems to correlate with poorer prognosis. Clin Cancer Res 14 (2008) 1686-1691
26. Doucas H., Mann C.D., Sutton C.D., Garcea G., Neal C.P., Berry D.P., and Manson M.M. Expression of nuclear Notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlates with the expression of STAT3 and phosphorylated Akt. J Surg Oncol 97 (2008) 63-68
27. Borg A., Tandon A.K., Sigurdsson H., Clark G.M., Ferno M., Fuqua S.A., Killander D., and McGuire W.L. HER-2/neu amplification predicts poor survival in node-positive breast cancer. Cancer Res 50 (1990) 4332-4337
28. Tsuda H., Hirohashi S., Shimosato Y., Hirota T., Tsugane S., Yamamoto H., Miyajima N., Toyoshima K., Yamamoto T., Yokota J., et al. Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1. Cancer Res 49 (1989) 3104-3108
29. Rubie H., Hartmann O., Michon J., Frappaz D., Coze C., Chastagner P., Baranzelli M.C., Plantaz D., Avet-Loiseau H., Benard J., Delattre O., Favrot M., Peyroulet M.C., Thyss A., Perel Y., Bergeron C., Courbon-Collet B., Vannier J.P., Lemerle J., and Sommelet D. N-Myc gene amplification is a major prognostic factor in localized neuroblastoma: results of the French NBL 90 study. Neuroblastoma Study Group of the Societe Francaise d'Oncologie Pediatrique. J Clin Oncol 15 (1997) 1171-1182