메뉴 건너뛰기




Volumn 19, Issue 4, 2014, Pages 4654-4668

Silymarin induces expression of pancreatic Nkx6.1 transcription factor and β-Cells Neogenesis in a pancreatectomy model

Author keywords

Insulin; Pancreatic regeneration; Pancreatic transcription factors

Indexed keywords

GLUCOSE BLOOD LEVEL; HOMEODOMAIN PROTEIN; INSULIN; NKX6A PROTEIN, RAT; PROTECTIVE AGENT; SILYMARIN;

EID: 84899555078     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules19044654     Document Type: Article
Times cited : (28)

References (41)
  • 1
    • 9444242665 scopus 로고    scopus 로고
    • Five stages of evolving beta cell dysfunction during progression to diabetes
    • Weir, G.C.; Bonner-Weir, S. Five stages of evolving beta cell dysfunction during progression to diabetes. Diabetes 2004, 53, S16-S21.
    • (2004) Diabetes , vol.53
    • Weir, G.C.1    Bonner-Weir, S.2
  • 2
    • 53649097239 scopus 로고    scopus 로고
    • Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic β cell
    • Bernardo, A.S.; Hay, C.W.; Docherty, K. Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic β cell. Mol. Cell Endocrinol. 2008, 294, 1-9.
    • (2008) Mol. Cell Endocrinol , vol.294 , pp. 1-9
    • Bernardo, A.S.1    Hay, C.W.2    Docherty, K.3
  • 3
    • 2542484345 scopus 로고    scopus 로고
    • The transcriptional repressor nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic β-cell differentiation: Evidence for feedback activation of the nkx6.1 gene by nkx6.1
    • Iype, T.; Taylor, D.G.; Ziesmann, S.M.; Garmey, J.C.; Watada, H.; Mirmira, R.G. The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic β-cell differentiation: Evidence for feedback activation of the nkx6.1 gene by Nkx6.1. Mol. Endocrinol. 2004, 18, 1363-1375.
    • (2004) Mol. Endocrinol , vol.18 , pp. 1363-1375
    • Iype, T.1    Taylor, D.G.2    Ziesmann, S.M.3    Garmey, J.C.4    Watada, H.5    Mirmira, R.G.6
  • 5
    • 0029027780 scopus 로고
    • Developmental biology of the pancreas
    • Slack, J.M. Developmental biology of the pancreas. Development 1995, 121, 1569-1580.
    • (1995) Development , vol.121 , pp. 1569-1580
    • Slack, J.M.1
  • 6
    • 0031775277 scopus 로고    scopus 로고
    • Rat endocrine pancreatic development in relation to two homeobox gene products (pdx-1 and nkx 6.1)
    • Oster, A.; Jensen, J.; Serup, P.; Galante, P.; Madsen, O.D.; Larson, L.I. Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1). J. Histochem. Cytochem. 1998, 46, 707-715.
    • (1998) J. Histochem. Cytochem , vol.46 , pp. 707-715
    • Oster, A.1    Jensen, J.2    Serup, P.3    Galante, P.4    Madsen, O.D.5    Larson, L.I.6
  • 7
    • 0030927342 scopus 로고    scopus 로고
    • The beta cell transcription factors and development of the pancreas
    • Sander, M.; German, M.S. The beta cell transcription factors and development of the pancreas. J. Mol. Med. 1997, 75, 327-340.
    • (1997) J. Mol. Med , vol.75 , pp. 327-340
    • Sander, M.1    German, M.S.2
  • 9
    • 0032525981 scopus 로고    scopus 로고
    • Beta cell specific inactivation of the mouse ipf1/pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
    • Ahlgren, U.; Jonson, J.; Jonson, L.; Simu, K.; Edlund, H. Beta cell specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev. 1998, 12, 1763-1768.
    • (1998) Genes Dev , vol.12 , pp. 1763-1768
    • Ahlgren, U.1    Jonson, J.2    Jonson, L.3    Simu, K.4    Edlund, H.5
  • 12
    • 84881255181 scopus 로고    scopus 로고
    • Mechanistic study of the biomimetic synthesis of flavonolignan diastereoisomers in milk thistle
    • Althagafy, H.S.; Meza-Aviña, M.E.; Oberlies, N.H.; Croatt, M.P. Mechanistic Study of the Biomimetic Synthesis of Flavonolignan Diastereoisomers in Milk Thistle. J. Org. Chem. 2013, 78, 7594-7600.
    • (2013) J. Org. Chem , Issue.78 , pp. 7594-7600
    • Althagafy, H.S.1    Meza-Aviña, M.E.2    Oberlies, N.H.3    Croatt, M.P.4
  • 13
    • 77956852506 scopus 로고    scopus 로고
    • Milk thistle in liver diseases: Past, present, future
    • Abenavoli, L.; Capasso, R.; Milic, N.; Capasso, F. Milk thistle in liver diseases: Past, present, future. Phytother. Res. 2010, 24, 1423-1432.
    • (2010) Phytother. Res , Issue.24 , pp. 1423-1432
    • Abenavoli, L.1    Capasso, R.2    Milic, N.3    Capasso, F.4
  • 14
    • 77955978501 scopus 로고    scopus 로고
    • Nkx6.1 transcription factor and ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors
    • Schaffer, A.E.; Freude, K.K.; Nelson, S.B.; Sander, M. Nkx6.1 transcription factor and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors. Dev. Cell 2010, 18, 1022-1029.
    • (2010) Dev. Cell , Issue.18 , pp. 1022-1029
    • Schaffer, A.E.1    Freude, K.K.2    Nelson, S.B.3    Sander, M.4
  • 15
    • 34447521981 scopus 로고    scopus 로고
    • The transcription factors nkx6.1 and nkx6.2 possess equivalent activities promoting beta-cell fate specification in pdx1+ pancreatic progenitor cells
    • Nelson, S.B.; Schaffer, A.E.; Sander, M. The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells. Development 2007, 134, 2491-2500.
    • (2007) Development , vol.134 , pp. 2491-2500
    • Nelson, S.B.1    Schaffer, A.E.2    Sander, M.3
  • 18
    • 0034640429 scopus 로고    scopus 로고
    • Beta-cell differentiation factor nkx6.1 contains distinct dna binding interference and transcriptional repression domains
    • Mirmira, R.G.; Watada, H.; German, M.S. Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains. J. Biol. Chem. 2000, 275, 14743-14751.
    • (2000) J. Biol. Chem , vol.275 , pp. 14743-14751
    • Mirmira, R.G.1    Watada, H.2    German, M.S.3
  • 19
    • 23944494573 scopus 로고    scopus 로고
    • The c-terminal domain of the β cell homeodomain factor nkx6.1 enhances sequence selective dna binding at the insulin promoter
    • Taylor, D.G.; Babu, D.; Mirmira, R.G. The C-terminal domain of the β cell homeodomain factor Nkx6.1 enhances sequence selective DNA binding at the insulin promoter. Biochemistry 2005, 44, 11269-11278.
    • (2005) Biochemistry , vol.44 , pp. 11269-11278
    • Taylor, D.G.1    Babu, D.2    Mirmira, R.G.3
  • 22
    • 84896488947 scopus 로고    scopus 로고
    • Effect of silymarin in pdx-1 expression and the proliferation of pancreatic β-cells in a pancreatectomy model
    • Soto, C.; Raya, L.; Juárez, J.; Pérez, J.; González, I. Effect of Silymarin in Pdx-1 expression and the proliferation of pancreatic β-cells in a pancreatectomy model. Phytomedicine 2014, 21, 233-239.
    • (2014) Phytomedicine , Issue.21 , pp. 233-239
    • Soto, C.1    Raya, L.2    Juárez, J.3    Pérez, J.4    González, I.5
  • 23
    • 0036195961 scopus 로고    scopus 로고
    • The phytoestrogen daidzein affects the antioxidant enzyme system of rat hepatoma h4iie cells
    • Röhrdanz, E.; Ohler, S.; Tran-Thi, Q.H.; Kahl, R. The phytoestrogen Daidzein affects the antioxidant enzyme system of rat hepatoma H4IIE cells. J. Nutr. 2002, 132, 370-375.
    • (2002) J. Nutr , vol.132 , pp. 370-375
    • Röhrdanz, E.1    Ohler, S.2    Tran-Thi, Q.H.3    Kahl, R.4
  • 24
    • 33746653397 scopus 로고    scopus 로고
    • Diverse flavonoids stimulate nodd1 binding to nod gene promoters in sinorhizobium meliloti
    • Peck, M.C.; Fisher, R.F.; Long, S.R. Diverse flavonoids stimulate NodD1 binding to nod gene promoters in Sinorhizobium meliloti. J. Bacteriol. 2006, 188, 5417-5427.
    • (2006) J. Bacteriol , vol.188 , pp. 5417-5427
    • Peck, M.C.1    Fisher, R.F.2    Long, S.R.3
  • 26
    • 0035930629 scopus 로고    scopus 로고
    • The role of hepatic nuclear factor 1a and pdx-1 transcriptional regulation of the pdx-1 gene
    • Gerrish, K.; Cisell, M.; Stein, R. The role of hepatic nuclear factor 1a and PDX-1 transcriptional regulation of the pdx-1 gene. J. Biol. Chem. 2001, 275, 47775-47784.
    • (2001) J. Biol. Chem , vol.275 , pp. 47775-47784
    • Gerrish, K.1    Cisell, M.2    Stein, R.3
  • 27
    • 0034711279 scopus 로고    scopus 로고
    • Autorregulation and maturity onset diabetes of the young transcription factors control the human pax4 promoter
    • Smith, S.; Watada, H.; Scheel, D.; Mrejen, C.; German M. Autorregulation and maturity onset diabetes of the young transcription factors control the human PAX4 promoter. J. Biol. Chem. 2000, 275, 36910-36919.
    • (2000) J. Biol. Chem , vol.275 , pp. 36910-36919
    • Smith, S.1    Watada, H.2    Scheel, D.3    Mrejen, C.4    German, M.5
  • 28
    • 0037403778 scopus 로고    scopus 로고
    • Pax6 autorregulation mediated by direct interaction of pax6 protein with the head surface ectoderm-specific enhancer of the mouse pax6 gene
    • Aota, S.; Nakajima, N.; Sakamoto, R.; Watanabe, S.; Ibaraki, N.; Okazaki, K. Pax6 autorregulation mediated by direct interaction of Pax6 protein with the head Surface ectoderm-specific enhancer of the mouse Pax6 gene. Dev. Biol. 2003, 257, 1-13.
    • (2003) Dev. Biol , vol.257 , pp. 1-13
    • Aota, S.1    Nakajima, N.2    Sakamoto, R.3    Watanabe, S.4    Ibaraki, N.5    Okazaki, K.6
  • 29
    • 0346024328 scopus 로고    scopus 로고
    • Neurogenin 3 activates the islet differentiation program while its own expression
    • Smith, S.; Watada, H.; German, M. Neurogenin 3 activates the islet differentiation program while its own expression. Mol. Endocrinol. 2004, 18, 142-149.
    • (2004) Mol. Endocrinol , vol.18 , pp. 142-149
    • Smith, S.1    Watada, H.2    German, M.3
  • 30
    • 0032716367 scopus 로고    scopus 로고
    • Cloning and dnabinding properties of the rat pancreatic β-cell-specific factor nkx6.1
    • Jorgensen, M.; Vestergard, P.; Petersen, H.; Ericson, J.; Madsen, O.; Serup, P. Cloning and DNAbinding properties of the rat pancreatic β-cell-specific factor Nkx6.1. FEBS Lett. 1999, 461, 287-294.
    • (1999) FEBS Lett , vol.461 , pp. 287-294
    • Jorgensen, M.1    Vestergard, P.2    Petersen, H.3    Ericson, J.4    Madsen, O.5    Serup, P.6
  • 31
    • 0025345242 scopus 로고
    • Direct and selective binding of an acidic transcriptional to the tata-box factor tfiid
    • Stringer, K.F.; Ingles, C.J.; Greenblatt, J. Direct and selective binding of an acidic transcriptional to the TATA-box factor TFIID. Nature 1990, 345, 783-786.
    • (1990) Nature , vol.345 , pp. 783-786
    • Stringer, K.F.1    Ingles, C.J.2    Greenblatt, J.3
  • 32
    • 0027218671 scopus 로고
    • Interaction between anacidic activator and transcription factor tfiib is required for transcriptionactivation
    • Roberts, S.G.; Ha, I.; Maldonado, E.; Reinberg, D.; Green, M.R. Interaction between anacidic activator and transcription factor TFIIB is required for transcriptionactivation. Nature 1993, 363, 741-744.
    • (1993) Nature , vol.363 , pp. 741-744
    • Roberts, S.G.1    Ha, I.2    Maldonado, E.3    Reinberg, D.4    Green, M.R.5
  • 35
    • 0345059197 scopus 로고    scopus 로고
    • Silymarin increases antioxidant enzymes in alloxan-induced diabetes mellitus in rat pancreas
    • Soto, C.P.; Recoba, R.; Barrón, H.; Alvarez, C.; Favari, L. Silymarin increases antioxidant enzymes in alloxan-induced diabetes mellitus in rat pancreas. Comp. Biochem. Physiol. Part C 2003, 136, 205-212.
    • (2003) Comp. Biochem. Physiol. Part C , vol.136 , pp. 205-212
    • Soto, C.P.1    Recoba, R.2    Barrón, H.3    Alvarez, C.4    Favari, L.5
  • 36
    • 0026443972 scopus 로고
    • Silymarin protects against paracetamol-induced lipid peroxidation and liver damage
    • Muriel, P.; Garciapiña, T.; Perez-Alvarez, V.; Mourelle, M. Silymarin protects against paracetamol-induced lipid peroxidation and liver damage. J. Appl. Toxicol. 1992, 12, 439-442.
    • (1992) J. Appl. Toxicol , vol.12 , pp. 439-442
    • Muriel, P.1    Garciapiña, T.2    Perez-Alvarez, V.3    Mourelle, M.4
  • 39
    • 0034694128 scopus 로고    scopus 로고
    • Effect of experimental treatment on housekeeping gene expression: Validation by real-time, quantitative rt-pcr
    • Schmittgen, T.; Zakrajsek, B. Effect of experimental treatment on housekeeping gene expression: Validation by real-time, quantitative RT-PCR. J. Biochem. Biophys. Methods 2000, 46, 69-81.
    • (2000) J. Biochem. Biophys. Methods , vol.46 , pp. 69-81
    • Schmittgen, T.1    Zakrajsek, B.2
  • 40
    • 73349120953 scopus 로고    scopus 로고
    • Pancreatic remodeling: Beta-cell apoptosis, proliferation and neogenesis, and the measurement of beta-cell mass and of individual beta-cell size
    • Stocker, C., Ed.; Humana Press: New York, NY, USA; Series, Charpter 11
    • Montanya, E.; Téllez, N. Pancreatic remodeling: Beta-cell apoptosis, proliferation and neogenesis, and the measurement of beta-cell mass and of individual beta-cell size. In Type 2 Diabetes, Methods in Molecular Biology; Stocker, C., Ed.; Humana Press: New York, NY, USA, 2009; Series volume 560, Charpter 11, pp. 137-158.
    • (2009) Type 2 Diabetes, Methods in Molecular Biology , vol.560 , pp. 137-158
    • Montanya, E.1    Téllez, N.2
  • 41
    • 0025349638 scopus 로고
    • Islet mass and function in diabetes and transplantation
    • Weir, G.; Bonner-Weir, S.; Leahy, J. Islet mass and function in diabetes and transplantation. Diabetes 1990, 39, 401-405.
    • (1990) Diabetes , vol.39 , pp. 401-405
    • Weir, G.1    Bonner-Weir, S.2    Leahy, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.