Polycyclic propargylamine and acetylene derivatives as multifunctional neuroprotective agents

European Journal of Medicinal Chemistry

Volumn 80, Issue , 2014, Pages 122-134

  Zindo, Frank T ^a   Barber, Quinton R ^b   Joubert, Jacques ^a   Bergh, Jacobus J ^b   Petzer, Jacobus P ^b   Malan, Sarel F ^a,b  

^a UNIVERSITY OF THE WESTERN CAPE   (South Africa)

^b NORTH WEST UNIVERSITY   (South Africa)

Author keywords

Apoptosis; Neuroprotection; Polycyclic; Propargylamine

Indexed keywords

8 PHENYL ETHYNYL 8 HYDROXYPENTACYCLOUNDECANE; ACETYLENE DERIVATIVE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; APOPTOSIS INHIBITOR; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; DIZOCILPINE; MEMANTINE; MONOAMINE OXIDASE INHIBITOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N PROPARGYL N BENZYL ADAMANTAN 1 AMINE; N,N DIPROPARGYL ADAMANTAN 1 AMINE; NEUROPROTECTIVE AGENT; NIMODIPINE; RASAGILINE; SELEGILINE; UNCLASSIFIED DRUG; ACETYLENE; AMINE OXIDASE (FLAVIN CONTAINING); PARGYLINE; PROPARGYLAMINE; PROPYLAMINE;

ALZHEIMER DISEASE; AMINATION; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING SITE; BLOOD BRAIN BARRIER; CELL MEMBRANE; COMPARATIVE STUDY; CONJUGATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; GRIGNARD REACTION; HYDROLYSIS; LIGAND BINDING; LIPOPHILICITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULE; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; RAT; REDUCTION; SUBSTITUTION REACTION; X RAY CRYSTALLOGRAPHY; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM; PROTEIN CONFORMATION;

ACETYLENE; APOPTOSIS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; HUMANS; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NEUROPROTECTIVE AGENTS; PARGYLINE; PROPYLAMINES; PROTEIN CONFORMATION; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84899533361     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.04.039     Document Type: Article

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