Physicochemical prediction of a brain-blood distribution profile in polycyclic amines

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 17, 2003, Pages 3569-3578

  Zah, Jaco ^a   Terre'Blanche, Gisella ^a   Erasmus, Elardus ^a   Malan, Sarel F ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

8 (4 NITROBENZYLAMINO) 8,11 OXAPENTACYCLO[5.4.0.0 2,6 .0 3,10 .0 5,9 ]UNDECANE; 8 BENZYLAMINO 8,11 OXAPENTACYCLO[5.4.0.0 2,6 .0 3,10 .0 5,9]UNDECANE; AMINE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; CARBON NUCLEAR MAGNETIC RESONANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; HYDROGEN BOND; HYDROPHOBICITY; INFRARED RADIATION; LINEAR REGRESSION ANALYSIS; MASS SPECTROMETRY; MOUSE; MOUSE STRAIN; NEUROPROTECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; STATISTICAL ANALYSIS; SYSTEM ANALYSIS;

EID: 0042623380     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00365-1     Document Type: Article

References (23)

1. Oliver D.W., Dekker T.G., Snyckers F.O. Arzneim.-Forsch. 41:1991;549.
2. Oliver D.W., Dekker T.G., Snyckers F.O. Eur. J. Med. Chem. 26:1991;375.
3. Malan S.F., Van den Heever I., Van der Schyf C.J. J. Pharm. Med. 6:1996;125.
4. Nguyen V.H., Mardon K., Kassiou M., Christie M.J. Nucl. Med. Biol. 26:1999;209.
5. Fujita T., Iwasa J., Hansch C. J. Am. Chem. Soc. 86:1964;5175.
6. ACD/ChemSketch® 4.54; Advanced Chemistry Development Inc.: Toronto, Canada, 2000.
7. ACD/LogP® 4.54; Advanced Chemistry Development Inc.: Toronto, Canada, 2000.
8. Hyperchem for Windows®; Hypercube Inc.: Ontario, Canada, 1994.
9. Burton P.S., Conradi R.A., Hilgers A.R., Ho N.F.H., Maggiora L.L. J. Control. Release. 19:1992;87.
10. Ghose A.K., Crippen G.M. J. Chem. Inf. Comput. Sci. 27:1987;21.
11. Viswanadhan V.N., Ghose A.K., Revankar G.R., Robins R.K. J. Chem. Inf. Comput. Sci. 29:1989;163.
12. Miller K.J. J. Am. Chem. Soc. 112:1990;8533.
13. Bodor N., Gabanyi Z., Wong C.-K. J. Am. Chem. Soc. 111:1989;3783.
14. Gavezzotti A. J. Am. Chem. Soc. 105:1983;5220.
15. Clark D.E. J. Pharm. Sci. 88:1999;815.
16. Hansch C. Acc. Chem. Res. 2:1969;232.
17. Feher M., Sourial E., Schmidt J.M. Int. J. Pharm. 201:2000;239.
18. Chikhale E.G., Ng K.-Y., Burton P.S., Borchard R.T. Pharm. Res. 11:1994;412.
19. Abraham M.H., Chadha H.S., Mitchell R.C. J. Pharm. Sci. 83:1994;1257.
20. Cookson R.C., Grundwell E., Hudec J. Chem. Ind. (London). 1958;1003.
21. Malan S.F., Van der Walt J.J., Van der Schyf C.J. Arch. Pharm. Pharm. Med. Chem. 333:2000;10.
22. Polak E. Computational Methods in Optimization, a Unified Approach. 1971;Academic, New York.
23. Lombardo F., Blake J.F., Curatolo W.J. J. Med. Chem. 39:1996;4750.