Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 13, 2011, Pages 3935-3944

  Joubert, Jacques ^a,b   Dyk, Sandra Van ^a   Green, Ivan R ^b   Malan, Sarel F ^a,b  

^a NORTH WEST UNIVERSITY   (South Africa)

^b UNIVERSITY OF THE WESTERN CAPE   (South Africa)

Author keywords

Amantadine; Antioxidant activity; Calcium channels; Neuroprotection; NMDA receptor; NOS inhibition

Indexed keywords

4 BENZYL 3 HYDROXY 4 AZAHEXACYCLO[5.4.1.0 2,6 .0 3,10 .0 5,9 .0 8,11]DODECANE; 7 NITROIMIDAZOLE; ADAMANTANE DERIVATIVE; AMANTADINE; ANTIOXIDANT; CALCIUM CHANNEL; CALCIUM CHANNEL AFFECTING AGENT; DIZOCILPINE; FLUORESCENT HETEROCYCLIC AMINOADAMANTANE DERIVATIVE; FREE RADICAL; N (1 ADAMANTYL) 2 OXO CHROMENE 3 CARBOXAMIDE; N (1 CYANO 2H ISOINDOL 2 YL)ADAMANTAN 1 AMINE; N (2,4 DINITROPHENYL)ADAMANTAN 1 AMINE; N ADAMANTAN 1 YL 1H INDAZOLE 3 CARBOXAMIDE; N ADAMANTAN 1 YL 2(METHYLAMINO)BENZAMIDE; N ADAMANTAN 1 YL 5 DIMETHYLAMINO 1 NAPHTHALENESULFONIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; NIFEDIPINE; NIMODIPINE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; MEMBRANE PERMEABILITY; NEUROPROTECTION; NONHUMAN; PHYSICAL CHEMISTRY; RAT; RECEPTOR BLOCKING;

ADAMANTANE; ANIMALS; BRAIN; CALCIUM CHANNELS; FLUORESCENT DYES; FREE RADICAL SCAVENGERS; MALE; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 79959515568     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.05.034     Document Type: Article

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