A novel anti-cancer effect of genistein: Reversal of epithelial mesenchymal transition in prostate cancer cells

Acta Pharmacologica Sinica

Volumn 29, Issue 9, 2008, Pages 1060-1068

  Zhang, Lin Lin ^a   Li, Lei ^a   Wu, Da Peng ^a   Fan, Jin Hai ^a   Li, Xiang ^a   Wu, Kai Jie ^a   Wang, Xin Yang ^a   He, Da Lin ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Cell invasion; Epithelial mesenchymal transition; Genistein; Prostate cancer

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CELL MARKER; G 6649; GENISTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL ASSAY; CELL DIFFERENTIATION; CELL INVASION; CELL PROLIFERATION; CELL STRUCTURE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CULTURE MEDIUM; DOSE RESPONSE; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; LOW DRUG DOSE; MESENCHYME CELL; PROSTATE CANCER; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOYBEAN; WESTERN BLOTTING;

ANTICARCINOGENIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GENISTEIN; HUMANS; MALE; NEOPLASM INVASIVENESS; PROSTATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRAZOLIUM SALTS; THIAZOLES;

EID: 51349125301     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2008.00831.x     Document Type: Article

References (30)

1. Edwards BK, Brown ML, Wingo PA, Howe HL, Ward E, Ries LA, et al. Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst 2005 97 : 1407 7.
2. Bracarda S, de Cobelli O, Greco C, Prayer-Galetti T, Valdagni R, Gatta G, et al. Cancer of the prostate. Crit Rev Oncol Hematol 2005 56 : 379 96.
3. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002 2 : 442 54.
4. Xu J, Wang R, Xie ZH, Odero-Marah V, Pathak S, Multani A, et al. Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis. Prostate 2006 66 : 1664 73.
5. Whitbread AK, Veveris-Lowe TL, Lawrence MG, Nicol DL, Clements JA. The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition. Biol Chem 2006 387 : 707 14.
6. Kasper S, Cookson MS. Mechanisms leading to the development of hormone-resistant prostate cancer. Urol Clin North Am 2006 33 : 201 10.
7. Messina MJ, Persky V, Setchell KD, Barnes S. Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr Cancer 1994 21 : 113 31.
8. Parnes HL, Figg WD. Chemoprevention in prostate cancer. Pharma-cotherapy 2006 26 : 1533.
9. Clinical development plan: genistein. J Cell Biochem Suppl 1996 26 : 114 26.
10. Severson RK, Nomura AM, Grove JS, Stemmermann GN. A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii. Cancer Res 1989 49 : 1857 60.
11. Schleicher RL, Lamartiniere CA, Zheng M, Zhang M. The inhibitory effect of genistein on the growth and metastasis of a transplantable rat accessory sex gland carcinoma. Cancer Lett 1999 136 : 195 201.
12. Valachovicova T, Slivova V, Bergman H, Shuherk J, Sliva D. Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-kappaB/AP-1 -dependent and -independent pathways. Int J Oncol 2004 25 : 1389 95.
13. Iishi H, Tatsuta M, Baba M, Yano H, Sakai N, Akedo H. Genistein attenuates peritoneal metastasis of azoxymethane-induced intestinal adenocarcinomas in Wistar rats. Int J Cancer 2000 86 : 416 20.
14. Davis JN, Singh B, Bhuiyan M, Sarkar FH. Genistein-induced up-regulation of p21WAFl, downregulation of cyclin B, and induction of apoptosis in prostate cancer cells. Nutr Cancer 1998 32 : 123 31.
15. Kyle E, Neckers L, Takimoto C, Curt G, Bergan R. Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity. Mol Pharmacol 1997 51 : 193 200.
16. Zhou JR, Gugger ET, Tanaka T, Guo Y, Blackburn GL, Clinton SK. Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. J Nutr 1999 129 : 1628 35.
17. Santibanez JF, Navarro A, Martinez J. Genistein inhibits proliferation and in vitro invasive potential of human prostatic cancer cell lines. Anticancer Res 1997 17 : 1199 204.
18. Davis JN, Muqim N, Bhuiyan M, Kucuk O, Pienta KJ, Sarkar FH. Inhibition of prostate specific antigen expression by genistein in prostate cancer cells. Int J Oncol 2000 16 : 1091 7.
19. Crowell JA, Holmes CJ. Agent identification and preclinical testing. Cancer Treat Res 2001 106 : 1 30.
20. Luo Y, He DL, Ning L, Shen SL, Li L, Li X. Hypoxia-inducible factor-1 alpha induces the epithelial-mesenchymal transition of human prostatecancer cells. Chin Med J (Engl) 2006 119 : 713 8.
21. Luo Y, He DL, Ning L, Shen SL, Li L, Li X, et al. Over-expression of hypoxia-inducible factor-lalpha increases the invasive potency of LNCaP cells in vitro. BJU Int 2006 98 : 1315 9.
22. Zhau HY, Chang SM, Chen BQ, Wang Y, Zhang H, Kao C, et al. Androgen-repressed phenotype in human prostate cancer. Proc Natl Acad Sci USA 1996 93 : 15152 7.
23. Jiang YG, Luo Y, He DL, Li X, Zhang LL, Peng T, et al. Role of Wnt/beta-catenin signaling pathway in epithelial-mesenchymal transition of human prostate cancer induced by hypoxia-inducible factor-lalpha. Int J Urol 2007 14 : 1034 9.
24. Romijn JC, Verkoelen CF, Schroeder FH. Application of the MTT assay to human prostate cancer cell lines in vitro: establishment of test conditions and assessment of hormone-stimulated growth and drug-induced cytostatic and cytotoxic effects. Prostate 1988 12 : 99 110.
25. Hempstock J, Kavanagh JP, George NJ. Growth inhibition of prostate cell lines in vitro by phyto-oestrogens. Br J Urol 1998 82 : 560 3.
26. Bhatia N, Agarwal R. Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells. Prostate 2001 46 : 98 107.
27. Peterson G, Barnes S. Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation. Prostate 1993 22 : 335 45.
28. Onozawa M, Fukuda K, Ohtani M, Akaza H, Sugimura T, Waka-bayashi K. Effects of soybean isoflavones on cell growth and apoptosis of the human prostatic cancer cell line LNCaP. Jpn J Clin Oncol 1998 28 : 360 3.
29. Geller J, Sionit L, Partido C, Li L, Tan X, Youngkin T, et al. Genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture. Prostate 1998 34 : 75 9.
30. Adlercreutz H, Markkanen H, Watanabe S. Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 1993 342 : 1209 10.