Honokiol Inhibits Non-Small Cell Lung Cancer Cell Migration by Targeting PGE2-Mediated Activation of β-Catenin Signaling

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Singh, Tripti ^b   Katiyar, Santosh K ^a,b  

^a BIRMINGHAM VA MEDICAL CENTER   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CAFFEIC ACID PHENETHYL ESTER; CASEIN KINASE IALPHA; CELECOXIB; CYCLOOXYGENASE 2; FH 535; GELATINASE A; GELATINASE B; GLYCOGEN SYNTHASE KINASE 3BETA; HONOKIOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROSTAGLANDIN E2; PROTEIN INHIBITOR; SERINE; SYNAPTOTAGMIN I; THREONINE; UNCLASSIFIED DRUG; WNT PROTEIN;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; DOWN REGULATION; DOWNSTREAM PROCESSING; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; METASTASIS; MIGRATION INHIBITION; MOLECULAR MECHANICS; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

BETA CATENIN; BIPHENYL COMPOUNDS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL MOVEMENT; CELL NUCLEUS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; DRUGS, CHINESE HERBAL; GENE KNOCKDOWN TECHNIQUES; HUMANS; LIGNANS; LUNG NEOPLASMS; NEOPLASM INVASIVENESS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SULFONAMIDES; TRANSCRIPTION FACTOR RELA;

MAGNOLIA;

EID: 84875989510     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060749     Document Type: Article

References (41)

1. American Cancer Society (2009) Cancer facts and figures 2009. Atlanta (GA): American Cancer Society.
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, et al. (2008) Cancer statistics. CA Cancer J Clin 58: 71-96.
3. Proctor RN, (2001) Tobacco and the global lung cancer epidemic. Nat Rev Cancer 1: 82-86.
4. Maziak DE, Markman BR, MacKay JA, Evans WK, (2004) Cancer Care Ontario Practice Guidelines Initiative Lung Cancer Disease Site Group (2004) Photodynamic therapy in nonsmall cell lung cancer: a systematic review. Ann Thorac Surg 77: 1484-1491.
5. Hoffman PC, Mauer AM, Vokes EE, (2000) Lung cancer. Lancet 355: 479-485.
6. Huang M, Stolina M, Sharma S, Mao JT, Zhu L, et al. (1998) Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: up-regulation of interleukin 10 and down-regulation of interleukin 12 production. Cancer Res 58: 1208-1216.
7. Hida T, Kozaki K, Muramatsu H, Masuda A, Shimizu S, et al. (2000) Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines. Clin Cancer Res 6: 2006-2011.
8. Hida T, Yatabe Y, Achiwa H, Muramatsu H, Kozaki K, et al. (1998) Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. Cancer Res 58: 3761-3764.
9. Wolff H, Saukkonen K, Anttila S, Karjalainen A, Vainio H, et al. (1998) Expression of cyclooxygenase-2 in human lung carcinoma. Cancer Res 58: 4997-5001.
10. Hosomi Y, Yokose T, Hirose Y, Nakajima R, Nagai K, et al. (2000) Increased cyclooxygenase 2 (COX-2) expression occurs frequently in precursor lesions of human adenocarcinoma of the lung. Lung Cancer 30: 73-81.
11. Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind JS, (2005) Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science 310(5753): 1504-1510.
12. Smith KA, Tong X, Abu-Yousif AO, Mikulec CC, Gottardi CJ, et al. (2012) UVB radiation-induced β-catenin signaling is enhanced by COX-2 expression in keratinocytes. Mol Carcinog 51: 734-745.
13. Ho MY, Liang SM, Hung SW, Liang CM (2012) MIG-7 controls COX-2/PGE2-mediated lung cancer metastasis. Cancer Res, Nov 13. [Epub ahead of print].
14. Barth AI, Nathke IS, Nelson WJ, (1997) Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways. Curr Opin Cell Biol 9: 683-690.
15. Liu C, Li Y, Semenov M, Han C, Baeg GH, et al. (2002) Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108: 837-847.
16. Moon RT, Kohn AD, De Ferrari GV, Kaykas A, (2004) WNT and beta-catenin signalling: diseases and therapies. Nat Rev Genet 5(9): 691-701.
17. Li TSC (2002) Chinese and related North American herbs: phytopharmacology and therapeutic values. Boca Raton, FL: CRC Press, 2002.
18. Bai X, Cerimele F, Ushio-Fukai M, Waqas M, Campbell PM, et al. (2003) Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem 278: 35501-35507.
19. Battle TE, Arbiser J, Frank DA, (2005) The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells. Blood 106: 690-697.
20. Chen F, Wang T, Wu YF, Gu Y, Xu XL, et al. (2004) Honokiol: a potent chemotherapy candidate for human colorectal carcinoma. World J Gastroenterol 10: 3459-3463.
21. Park EJ, Min HY, Chung HJ, Hong JY, Kang YJ, et al. (2009) Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells. Cancer Lett 277: 133-140.
22. Hahm ER, Arlotti JA, Marynowski SW, Singh SV, (2008) Honokiol, a constituent of oriental medicinal herb magnolia officinalis, inhibits growth of PC-3 xenografts in vivo in association with apoptosis induction. Clin Cancer Res 14: 1248-1257.
23. Arora S, Singh S, Piazza GA, Contreras CM, Panyam J, et al. (2012) Honokiol: a novel natural agent for cancer prevention and therapy. Curr Mol Med 12: 1244-1252.
24. Ponnurangam S, Mammen JM, Ramalingam S, He Z, Zhang Y, et al. (2012) Honokiol in combination with radiation targets notch signaling to inhibit colon cancer stem cells. Mol Cancer Ther 11: 963-972.
25. Vaid M, Sharma SD, Katiyar SK, (2010) Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: Development of topical formulation. Carcinogenesis 31: 2004-2011.
26. Singh T, Sharma SD, Katiyar SK, (2011) Grape seed proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells in vitro and in vivo. PLoS ONE 6: e27444.
27. Singh T, Katiyar SK, (2011) Honokiol, a phytochemical from Magnolia spp., inhibits breast cancer cell migration by targeting nitric oxide and cyclooxygenase-2. Int J Oncol 38: 769-776.
28. Vaid M, Prasad R, Sun Q, Katiyar SK, (2011) Silymarin targets β-catenin signaling in blocking migration/invasion of human melanoma cells. PLoS ONE 6(7): e23000.
29. Singh T, Vaid M, Katiyar N, Sharma S, Katiyar SK (2011) Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E2 and prostaglandin E2 receptors. Carcinogenesis.
30. Mantena SK, Sharma SD, Katiyar SK, (2006) Berberine, a natural product, induces G1 phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. Mol Cancer Ther 5: 296-308.
31. Kim J, Lakshmikanthan V, Frilot N, Daaka Y, (2010) Prostaglandin E2 promotes lung cancer cell migration via EP4-βArrestin1-c-Src signalsome. Mol Cancer Res 8: 569-577.
32. Kolligs FT, Bommer G, Goke B (2002) Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. Digestion 66, 131-144.
33. Brabletz T, Jung A, Dag S, Reu S, Kirchner T, (2000) β-catenin induces invasive growth by activating matrix metalloproteinases in colorectal carcinoma. Verhandlungen der Deutschen. Gesellschaft fur Pathologie 84: 175-181.
34. Hlubek F, Spaderna S, Jung A, Kirchner T, Brabletz T, (2004) Beta-catenin activates a coordinated expression of the proinvasive factors laminin-5 gamma2 chain and MT1-MMP in colorectal carcinomas. Int J Cancer 108: 321-326.
35. Mukhtar H, Elmets CA, (1996) Photocarcinogenesis: mechanisms, models and human health implications. Photochem Photobiol 63: 355-447.
36. Punathil T, Katiyar SK, (2009) Inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2. Mol Carcinog 48: 232-242.
37. Punathil T, Tollefsbol TO, Katiyar SK, (2008) EGCG inhibits mammary cancer cell migration through inhibition of nitric oxide synthase and guanylate cyclase. Biochem Biophys Res Commun 375: 162-167.
38. Vaid M, Singh T, Katiyar SK, (2011) Grape seed proanthocyanidins inhibit melanoma cell invasiveness by reduction of PGE2 synthesis and reversal of epithelial-to-mesenchymal transition. PLoS ONE 6: e21539.
39. Hart M, Concordet JP, Lassot I, Albert I, del los Santos R, et al. (1999) The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Curr Biol 9: 207-210.
40. Tuynman JB, Vermeulen L, Boon EM, Kemper K, Zwinderman AH, et al. (2008) Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer. Cancer Res 68: 1213-1220.
41. Shlomo H, Simon JA, (2008) A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities. Mol Cancer Ther 7: 521-529.