Synthesis of a terphenyl substituted 4-aza-2,3-didehydropodophyllotoxin analogues as inhibitors of tubulin polymerization and apoptosis inducers

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 9, 2014, Pages 2714-2723

  Kamal, Ahmed ^a   Tamboli, Jaki R ^a   Lakshma Nayak, V ^a   Adil, S F ^b   Vishnuvardhan, M V P S ^a   Ramakrishna, S ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Anticancer activity; Apoptosis; Caspase 3 activation; DNA fragmentation; Hoechst staining; Inhibition of tubulin polymerization; Multicomponent synthesis; Podophyllotoxin

Indexed keywords

4-AZA-2,3-DIDEHYDROPODOPHYLLOTOXIN; ANTINEOPLASTIC AGENT; CASPASE 3; PODOPHYLLOTOXIN; TUBULIN; TUBULIN MODULATOR;

ANALOGS AND DERIVATIVES; APOPTOSIS; CHEMISTRY; DNA FRAGMENTATION; DRUG EFFECTS; DRUG SCREENING; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; METABOLISM; POLYMERIZATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; DNA FRAGMENTATION; DRUG SCREENING ASSAYS, ANTITUMOR; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; PODOPHYLLOTOXIN; POLYMERIZATION; TUBULIN; TUBULIN MODULATORS;

EID: 84899460776     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.03.021     Document Type: Article

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