Fractal analysis of shape changes in murine osteoblasts cultured under simulated microgravity

Rendiconti Lincei

Volumn 25, Issue SUPPL. 1, 2014, Pages

  Testa, Fabrizio ^a   Palombo, Alessandro ^a,b   Dinicola, Simona ^a   D'Anselmi, Fabrizio ^a   Proietti, Sara ^a   Pasqualato, Alessia ^a,c   Grazia Masiello, Maria ^a   Coluccia, Pierpaolo ^a   Cucina, Alessandra ^a   Bizzarri, Mariano ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

Author keywords

Fractal dimension; Microgravity; Osteoblast; Shape; Symmetry breaking

Indexed keywords

CELL DEATH; FRACTAL DIMENSION; MANNED SPACE FLIGHT; MICROGRAVITY PROCESSING; OSTEOBLASTS;

FRACTAL ANALYSIS; FUNCTIONAL CHANGES; INHIBITED GROWTH; MORPHOLOGICAL CHANGES; MURINE OSTEOBLASTS; SHAPE; SIMULATED MICROGRAVITY; SYMMETRY-BREAKING;

MICROGRAVITY;

MURINAE;

EID: 84899422013     PISSN: 20374631     EISSN: 17200776     Source Type: Journal    
DOI: 10.1007/s12210-014-0291-3     Document Type: Article

References (36)

1. Albrecht-Buehler G (1991) Possible mechanisms of indirect gravity sensing by cells. ASGSB Bull 4(2):25-34
2. Bacabac RG, Smit TH, Mullender MG, Dijcks SJ, Van Loon JJWA, Klein-Nulend J (2004) Nitric oxide production by bone cells is fluid shear stress rate dependent. Biochem Biophys Res Commun 315(823-829):2004
3. Bizzarri M, Giuliani A (2011) Representing cancer cell trajectories in a phase-space diagram: switching cellular states by biological phase transitions. In: Dehmer M, Emmert-Streib F, Graber A, Salvador A (eds) Applied statistics for network biology: methods in systems biology. Wiley-VCH Verlag GmbH & Co. KGaA, Germany
4. Bizzarri M, Saggese E (2012) Human space flights: facts and dreams. Ann Kinesiol 2(2):103-116
5. Bizzarri M, Giuliani A, Cucina A, D'Anselmi F, Soto AM, Sonnenschein C (2011) Fractal analysis in a systems biology approach to cancer. Semin Cancer Biol 21(3):175-182
6. Bizzarri M, Pasqualato A, Cucina A, Pasta V (2013a) Physical forces and non linear dynamics mould fractal cell shape. Quantitative morphological parameters and cell phenotype. Histol Histopathol 28(2):155-174
7. Bizzarri M, Palombo A, Cucina A (2013b) Theoretical aspects of systems biology. Prog Biophys Mol Biol 112(1-2):33-43
8. Cutting JE, Garvin JJ (1987) Fractal curves and complexity. Percept Psicophysiol 42:365-370
9. Dinicola S, D'Anselmi F, Pasqualato A, Proietti S, Lisi E, Cucina A, BizzarriM(2011) A systems biology approach to cancer: fractals, attractors, and non-linear dynamics. OMICS 15(3):93-104
10. Ferreira T, Rasband W (2012) ImageJ user guide IJ 1.46r. http://www.imageJ.org
11. Flusberg DA, Nimaguchi Y, Ingber DE (2001) Cooperative control of Akt phosphorylation, bcl-2 expression and apoptosis by cytoskeletal microfilaments and microtubules in capillary endothelial cells. Mol Biol Cell 12:3087-3094
12. Gaboyard S, Blanchard MP, Travo BT, Viso M, Sans A, Lehouelleur J (2002) Weightlessness affects cytoskeleton of rat utricular hair cells during maturation in vitro. Neuroreport 13(16):2139-2142
13. Guignandon M, Lafage-Proust MH (2013) http://rsbweb.nih.gov/ij/plugins/ fraclac/FLHelp/Introduction.htm
14. Honga D, Chen H-X, Yuc H-Q, Lianga Y, Wanga C, Liand Q-Q, Dengc H-T, Gea R-S (2010) Morphological and proteomic analysis of early stage of osteoblast differentiation in osteoblastic progenitor cells. Exp Cell Res 316:2291-2300
15. Hughes-Fulford M (2002) Physiological effects of microgravity on osteoblast morphology and cell biology. Adv Space Biol Med 8:129-157
16. Hughes-Fulford M (2003) Function of the cytoskeleton in gravisensing during spaceflight. Adv Space Res 32(8):1585-1593
17. Ingber DE, Tensegrity I (2003) Cell structure and hierarchical systems biology. J Cell Sci 116:1157-1173
18. Johnson PR (1979) Prolonged weightlessness and calcium loss in man. Acta Astronaut 6:1113-1122
19. Kheradmand F, Werner E, Tremble P, Symons M, Werb Z (1998) Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change. Science 280:898-902
20. Kondepudi DK, Storm PB (1992) Gravity detection through bifurcation. Adv Space Res 12(1):7-14
21. Losa GA (2009) The fractal geometry of life. Riv Biol Biol Forum 102(1):29-59
22. Mandelbrot BB (1982) The fractal geometry of nature. W.H. Freeman, New York
23. Marie PJ, Jones D, Vico L, Zallone A, Hinsenkamp M, Cancedda R (2000) Osteobiology, strain, and microgravity. Part I. Studies at the cellular level. Calcif Tissue Int 67:2-9
24. Owan I, Burr DB, Turner CH, Qiu J, Tu Y, Onyia JE, Duncan RL (1997) Mechanotransduction in bone: osteoblasts are more responsive to fluid forces than mechanical strain. Am J Physiol 273:C810-C815
25. Papaseit C, Pchon N, Tabony J (2000) Microtubule self-organization is gravity-dependent. Proc Natl Acad Sci USA 8(15):8364-8368
26. Patel PMJ, Sykes MC, Platt MO, Boyd NL, Sorescu GP, Xu M, van Loon JJWA, May D, Wang MD, Jo H (2005) Simulated microgravity using the Random Positioning Machine inhibits differentiation and alters gene expression profiles of 2T3 preosteoblasts. Am J Physiol Cell Physiol 288:C1211-C1221
27. Qian AR, Li D, Han J, Gao X, Di SM, Zhang W, Hu LF, Shang P (2012) Fractal dimension as a measure of altered actin cytoskeleton in MC3T3-E1 cells under simulated microgravity using 3-D/2-D clinostats. IEEE Trans Biomed Eng 59(5):1374-1380
28. Rittweger J, Simunic B, Bilancio G, De Santo NG, Cirillo M, Biolo G, Pisot R, Eiken O, Mekjavic IB, Narici M (2009) Bone loss in the lower leg during 35 days of bed rest is predominantly from the cortical compartment. Bone 44:612-618
29. Smith TG Jr, Lange GD, Marks WB (1996) Fractal methods and results in cellular morphology. J Neurosci Methods 69: 1123-126. http://rsbweb.nih.gov/ij/ plugins/fraclac/FLHelp/Introduction.htm
30. Sytkowski AJ, Davis KL (2001) Erythroid cell growth and differentiation in vitro in the simulated microgravity environment of the NASA rotation wall vessel bioreactor. In Vitro Cell Dev Biol Anim 37:79-83
31. Tél T (1988) Fractals, multifractals and thermodynamics. Z Naturforsch 43a:1154-1174
32. Usson N, Laroche A, Caillot-Augusseau C, Alexandre L (2001) Vico, cell cycling determines integrin-mediated adhesion in osteoblastic ROS 17/2.8 cells exposed to space-related conditions. FASEB J 15(11):2036-2038
33. Van Loon JWA (2007) Some history and use of the random positioning machine, RPM, in gravity related research. Adv Space Res 39:1161-1165
34. Vico L (2006) What do we know about alteration in the osteoblast phenotype with microgravity? J Musculoskelet Neuronal Interact 6(4):317-318
35. Vico L, Lafage-Proust MH, Alexandrfe C (1998) Effects of gravitational changes on the bone system in vitro and in vivo. Bone 22:95S-100S
36. Wang N, Butler JP, Ingber DE (1993) Mechanotransduction across the cell surface and through the cytoskeleton. Science 260: 1124-1127