Monocyte to macrophage differentiation goes along with modulation of the plasmalogen pattern through transcriptional regulation

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Wallner, Stefan ^a   Grandl, Margot ^a   Konovalova, Tatiana ^a   Sigrüner, Alexander ^a   Kopf, Thomas ^a   Peer, Markus ^a   Orsó, Evelyn ^a   Liebisch, Gerhard ^a   Schmitz, Gerd ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; GLYCEROPHOSPHOLIPID; ICOSANOID; KRUPPEL LIKE FACTOR 4; LIPIDOME; NUCLEAR FACTOR Y; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLASMALOGEN; ZINC FINGER PROTEIN; TRANSCRIPTOME;

ARTICLE; CELL DIFFERENTIATION; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; FATTY ACID DESATURATION; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; GENE EXPRESSION; GENE REGULATORY NETWORK; GRANULOCYTE; LIPID METABOLISM; LIPIDOMICS; MACROPHAGE; MONOCYTE; TRANSCRIPTION REGULATION; UPREGULATION; CYTOLOGY; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; PHYSIOLOGY;

CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HUMANS; MACROPHAGES; MONOCYTES; PLASMALOGENS; TRANSCRIPTOME;

EID: 84899421478     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094102     Document Type: Article

References (83)

1. Moore KJ, Tabas I (2011) Macrophages in the pathogenesis of atherosclerosis. Cell 145: 341-355.
2. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, et al. (2004) The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25: 677-686.
3. Gordon S, Taylor PR (2005) Monocyte and macrophage heterogeneity. Nat Rev Immunol 5: 953-964.
4. Sica A, Mantovani A (2012) Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 122: 787-795.
5. Gautier EL, Huby T, Witztum JL, Ouzilleau B, Miller ER, et al. (2009) Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage. Circulation 119: 1795-1804.
6. Buddecke E, Andresen G (1959) [Studies on the chemistry of the arterial wall. IV. Quantitative determination of the acetalphosphatides (plasmalogens) in human aorta with consideration to arteriosclerosis]. Hoppe Seylers Z Physiol Chem 314: 38-45.
7. Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444: 860-867.
8. Simons K, Toomre D (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1: 31-39.
9. Palsdottir H, Hunte C (2004) Lipids in membrane protein structures. Biochim Biophys Acta 1666: 2-18.
10. Engelman DM (2005) Membranes are more mosaic than fluid. Nature 438: 578-580.
11. Wallner S, Schmitz G (2011) Plasmalogens the neglected regulatory and scavenging lipid species. Chem Phys Lipids 164: 573-589.
12. Leidl K, Liebisch G, Richter D, Schmitz G (2008) Mass spectrometric analysis of lipid species of human circulating blood cells. Biochim Biophys Acta 1781: 655-664.
13. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW (1999) C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 19: 972-978.
14. Graessler J, Schwudke D, Schwarz PE, Herzog R, Shevchenko A, et al. (2009) Top-down lipidomics reveals ether lipid deficiency in blood plasma of hypertensive patients. PLoS One 4: e6261.
15. Stenvinkel P, Diczfalusy U, Lindholm B, Heimburger O (2004) Phospholipid plasmalogen, a surrogate marker of oxidative stress, is associated with increased cardiovascular mortality in patients on renal replacement therapy. Nephrol Dial Transplant 19: 972-976.
16. Lessig J, Fuchs B (2009) Plasmalogens in biological systems: their role in oxidative processes in biological membranes, their contribution to pathological processes and aging and plasmalogen analysis. Curr Med Chem 16: 2021-2041.
17. Ecker J, Liebisch G, Englmaier M, Grandl M, Robenek H, et al. (2010) Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes. Proc Natl Acad Sci U S A 107: 7817-7822.
18. Zemski Berry KA, Murphy RC (2004) Electrospray ionization tandem mass spectrometry of glycerophosphoethanolamine plasmalogen phospholipids. J Am Soc Mass Spectrom 15: 1499-1508.
19. Muller G, Kerkhoff C, Hankowitz J, Pataki M, Kovacs E, et al. (1993) Effects of purinergic agents on human mononuclear phagocytes are differentiation dependent. Implications for atherogenesis. Arterioscler Thromb 13: 1317-1326.
20. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, et al. (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76-85.
21. Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911-917.
22. Liebisch G, Lieser B, Rathenberg J, Drobnik W, Schmitz G (2004) High-throughput quantification of phosphatidylcholine and sphingomyelin by electrospray ionization tandem mass spectrometry coupled with isotope correction algorithm. Biochim Biophys Acta 1686: 108-117.
23. Liebisch G, Vizcaino JA, Kofeler H, Trotzmuller M, Griffiths WJ, et al. (2013) Shorthand notation for lipid structures derived from mass spectrometry. J Lipid Res 54: 1523-1530.
24. Geladi P, Kowalski BR (1986) Partial least-squares regression: a tutorial. Analytica Chimica Acta 185: 1-17.
25. Barker M, Rayens W (2003) Partial least squares for discrimination. Journal of Chemometrics 17: 166-173.
26. Waterbeemd Hvd (1995) Chemometric methods in molecular design. 2.
27. Kondrakhin YV, Sharipov RN, Keld AE, Kolpakov FA (2008) Identification of differentially expressed genes by meta-analysis of microarray data on breast cancer. In Silico Biol 8: 383-411.
28. R Core Team (2013) R: A Language and Environment for Statistical Computing. [2.15.3]. R Foundation for Statistical Computing. Ref Type: Computer Program
29. Castelo R, Roverato A (2009) Reverse engineering molecular regulatory networks from microarray data with qp-graphs. J Comput Biol 16: 213-227.
30. Castelo R, Roverato A (2012) Inference of regulatory networks from microarray data with R and the bioconductor package qpgraph. Methods Mol Biol 802: 215-233.
31. Castelo R, Roverato A (2006) A robust procedure for Gaussian graphical model search from microarray data with p larger than n. JMLR 7: 2621-2650.
32. Jakobsson A, Westerberg R, Jacobsson A (2006) Fatty acid elongases in mammals: their regulation and roles in metabolism. Prog Lipid Res 45: 237-249.
33. Leonard AE, Bobik EG, Dorado J, Kroeger PE, Chuang LT, et al. (2000) Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids. Biochem J 350 Pt 3: 765-770.
34. Wang Y, Torres-Gonzalez M, Tripathy S, Botolin D, Christian B, et al. (2008) Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition. J Lipid Res 49: 1538-1552.
35. Matsuzaka T, Shimano H, Yahagi N, Yoshikawa T, Amemiya-Kudo M, et al. (2002) Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs. J Lipid Res 43: 911-920.
36. Moon YA, Shah NA, Mohapatra S, Warrington JA, Horton JD (2001) Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. J Biol Chem 276: 45358-45366.
37. Ikeda M, Kanao Y, Yamanaka M, Sakuraba H, Mizutani Y, et al. (2008) Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis. FEBS Lett 582: 2435-2440.
38. Marquardt A, Stohr H, White K, Weber BH (2000) cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics 66: 175-183.
39. Ntambi JM, Miyazaki M (2004) Regulation of stearoyl-CoA desaturases and role in metabolism. Prog Lipid Res 43: 91-104.
40. McAndrew RP, Wang Y, Mohsen AW, He M, Vockley J, et al. (2008) Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase. J Biol Chem 283: 9435-9443.
41. Maeba R, Maeda T, Kinoshita M, Takao K, Takenaka H, et al. (2007) Plasmalogens in human serum positively correlate with high- density lipoprotein and decrease with aging. J Atheroscler Thromb 14: 12-18.
42. Seo HS, Lombardi DM, Polinsky P, Powell-Braxton L, Bunting S, et al. (1997) Peripheral vascular stenosis in apolipoprotein E-deficient mice. Potential roles of lipid deposition, medial atrophy, and adventitial inflammation. Arterioscler Thromb Vasc Biol 17: 3593-3601.
43. Gelissen IC, Hochgrebe T, Wilson MR, Easterbrook-Smith SB, Jessup W, et al. (1998) Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: a potential anti-atherogenic function? Biochem J 331 (Pt 1): 231-237.
44. Jong MC, Hofker MH, Havekes LM (1999) Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3. Arterioscler Thromb Vasc Biol 19: 472-484.
45. Berbee JF, van der Hoogt CC, Kleemann R, Schippers EF, Kitchens RL, et al. (2006) Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in gram-negative sepsis. FASEB J 20: 2162-2164.
46. Westerterp M, Van EM, de HW, Offerman EH, Van Berkel TJ, et al. (2007) Apolipoprotein CI aggravates atherosclerosis development in ApoE-knockout mice despite mediating cholesterol efflux from macrophages. Atherosclerosis 195: e9-16.
47. Babaev VR, Fazio S, Gleaves LA, Carter KJ, Semenkovich CF, et al. (1999) Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo. J Clin Invest 103: 1697-1705.
48. Tsutsumi K (2003) Lipoprotein lipase and atherosclerosis. Curr Vasc Pharmacol 1: 11-17.
49. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, et al. (2005) Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem 280: 21763-21772.
50. Zhang K, Kaufman RJ (2008) From endoplasmic-reticulum stress to the inflammatory response. Nature 454: 455-462.
51. Tobert JA (2003) Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov 2: 517-526.
52. Yvan-Charvet L, Ranalletta M, Wang N, Han S, Terasaka N, et al. (2007) Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. J Clin Invest 117: 3900-3908.
53. Oram JF, Lawn RM, Garvin MR, Wade DP (2000) ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages. J Biol Chem 275: 34508-34511.
54. Klucken J, Buchler C, Orso E, Kaminski WE, Porsch-Ozcurumez M, et al. (2000) ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Proc Natl Acad Sci U S A 97: 817-822.
55. Tang C, Liu Y, Kessler PS, Vaughan AM, Oram JF (2009) The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor. J Biol Chem 284: 32336-32343.
56. Tang C, Oram JF (2009) The cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes. Biochim Biophys Acta 1791: 563-572.
57. Parini P, Davis M, Lada AT, Erickson SK, Wright TL, et al. (2004) ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver. Circulation 110: 2017-2023.
58. Calder PC (2012) Mechanisms of action of (n-3) fatty acids. J Nutr 142: 592S-599S.
59. Funk CD (2001) Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294: 1871-1875.
60. Farooqui AA, Yang HC, Hirashima Y, Horrocks LA (1999) Determination of plasmalogen-selective phospholipase A2 activity by radiochemical and fluorometric assay procedures. Methods Mol Biol 109: 39-47.
61. Bakhle YS (1999) Structure of COX-1 and COX-2 enzymes and their interaction with inhibitors. Drugs Today (Barc) 35: 237-250.
62. Hulsmans M, Holvoet P (2010) The vicious circle between oxidative stress and inflammation in atherosclerosis. J Cell Mol Med 14: 70-78.
63. Colas R, Sassolas A, Guichardant M, Cugnet-Anceau C, Moret M, et al. (2011) LDL from obese patients with the metabolic syndrome show increased lipid peroxidation and activate platelets. Diabetologia 54: 2931-2940.
64. Xu H, Barnes GT, Yang Q, Tan G, Yang D, et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112: 1821-1830.
65. Kelly LM, Englmeier U, Lafon I, Sieweke MH, Graf T (2000) MafB is an inducer of monocytic differentiation. EMBO J 19: 1987-1997.
66. Meimaridou E, Gooljar SB, Chapple JP (2009) From hatching to dispatching: the multiple cellular roles of the Hsp70 molecular chaperone machinery. J Mol Endocrinol 42: 1-9.
67. Morano KA (2007) New tricks for an old dog: the evolving world of Hsp70. Ann N Y Acad Sci 1113: 1-14.
68. Tavaria M, Gabriele T, Kola I, Anderson RL (1996) A hitchhiker's guide to the human Hsp70 family. Cell Stress Chaperones 1: 23-28.
69. Wegele H, Muller L, Buchner J (2004) Hsp70 and Hsp90-a relay team for protein folding. Rev Physiol Biochem Pharmacol 151: 1-44.
70. Kirkegaard T, Roth AG, Petersen NH, Mahalka AK, Olsen OD, et al. (2010) Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology. Nature 463: 549-553.
71. Schroder O, Schulte KM, Ostermann P, Roher HD, Ekkernkamp A, et al. (2003) Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury. Crit Care Med 31: 73-79.
72. Laurin M, Fradet N, Blangy A, Hall A, Vuori K, et al. (2008) The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo. Proc Natl Acad Sci U S A 105: 15446-15451.
73. Cote JF, Motoyama AB, Bush JA, Vuori K (2005) A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling. Nat Cell Biol 7: 797-807.
74. Piao L, Nakagawa H, Ueda K, Chung S, Kashiwaya K, et al. (2011) C12orf48, termed PARP-1 binding protein, enhances poly(ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells from DNA damage. Genes Chromosomes Cancer 50: 13-24.
75. van DS, Cordeiro R, Craig T, van DJ, Wood SH, et al. (2012) GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases. BMC Genomics 13: 535.
76. Hotta Y, Furukawa K, Tabata S (1995) Meiosis specific transcription and functional proteins. Adv Biophys 31: 101-115.
77. Doherty GJ, Ahlund MK, Howes MT, Moren B, Parton RG, et al. (2011) The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading. Mol Biol Cell 22: 4380-4389.
78. Garcia-Anoveros J, Derfler B, Neville-Golden J, Hyman BT, Corey DP (1997) BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc Natl Acad Sci U S A 94: 1459-1464.
79. Junttila MR, Puustinen P, Niemela M, Ahola R, Arnold H, et al. (2007) CIP2A inhibits PP2A in human malignancies. Cell 130: 51-62.
80. Liao X, Sharma N, Kapadia F, Zhou G, Lu Y, et al. (2011) Kruppel-like factor 4 regulates macrophage polarization. J Clin Invest 121: 2736-2749.
81. Krishnaraju K, Nguyen HQ, Liebermann DA, Hoffman B (1995) The zinc finger transcription factor Egr-1 potentiates macrophage differentiation of hematopoietic cells. Mol Cell Biol 15: 5499-5507.
82. Nguyen HQ, Hoffman-Liebermann B, Liebermann DA (1993) The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage. Cell 72: 197-209.
83. Reed BD, Charos AE, Szekely AM, Weissman SM, Snyder M (2008) Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes. PLoS Genet 4: e1000133.