Peripheral vascular stenosis in apolipoprotein e-deficient mice: Potential roles of lipid deposition, medial atrophy, and adventitial inflammation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 12, 1997, Pages 3593-3601

  Seo, Hong Seog ^a   Lombardi, Donna M ^a   Polinsky, Patti ^a   Powell Braxton, Lyn ^b   Bunting, Stuart ^b   Schwartz, Stephen M ^a   Rosenfeld, Michael E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b GENENTECH INC   (United States)

Author keywords

Adventitial inflammation; Apolipoprotein E; Compensatory remodeling; Medial necrosis; Stenosis

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; LIPID; PROTEIN;

ADVENTITIA; ANIMAL MODEL; ANIMAL TISSUE; ARTERY MEDIA; ARTERY OCCLUSION; ARTICLE; ATHEROSCLEROSIS; ATROPHY; DISEASE SEVERITY; ELECTRON MICROSCOPY; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIPID STORAGE; LIPOPROTEIN DEFICIENCY; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL;

EID: 17344367451     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.12.3593     Document Type: Article

References (11)

1. Clarkson TB, Prichard RW, Morgan TM, Petrick GS, Klein KP. Remodeling of coronary arteries in human and nonhuman primates. JAMA. 1994;271:289-294.
2. Rapacz J, Hasler-Rapacz J, Taylor KM, Checovich WJ, Attie AD. Lipoprotein mutations in pigs are associated with elevated plasma cholesterol and atherosclerosis. Science. 1986;234:1573.
3. Kakuta T, Currier JW, Haudenschild CC, Ryan TJ, Faxon DP. Differences in compensatory vessel enlargement, not intimal formation, account for restenosis after angioplasty in the hypercholesterolemic rabbit model. Circulation. 1994;89:2809-2815.
4. Post MJ, Borst C, Kuntz RE. The relative importance of arterial remodeling compared with intimal hyperplasia in lumen renarrowing after balloon angioplasty: a study in the normal rabbit and the hypercholesterolemic Yucatan micropig. Circulation. 1994;89:2816-2821.
5. Stadius ML, Gown AM, Kernoff R, Schwartz SM. Does sequential balloon injury of an artery lead to a different outcome than a single injury? An experimental study of angioplasty. Coron Art Dis. 1996;7:247-255.
6. Mintz G S, Popma JJ, Pichard AD, Kent KM, Satler LF, Wong C, Hong MK, Kovach JA, Leon MB. Arterial remodeling after coronary angioplasty: a serial intravascular ultrasound study. Circulation.. 1996;94:35-43.
7. Breslow JL. Mouse models of atherosclerosis. Science. 1996;272:685.
8. Fazio S, Lee Y, Sheng Z, Rall SC Jr. Type III hyperlipoproteinemic phenotype in transgcnic mice expressing dysfunctional apolipoprotein E. J Clin Invest. 1993;92:1497.
9. Piedrahita JA, Zhang SH, Hagaman JR, Oliver PM, Maeda N. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryogenic stem cells. Proc Natl Acad Sci U S A.. 1992;89:4471.
10. Plump AS, Smith JD, Hayek T, Aalto-Setala K, Walsh A, Verstuyft J, Rubin E, Breslow J. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992;71:343.
11. Zhang SH, Reddick RL, Piedrahita J, Maeda M. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 1992;258:468.