Metabolic regulation of feed intake in monogastric mammals

Voluntary Feed Intake in Pigs

Volumn , Issue , 2009, Pages 189-213

  Black, John L ^a   Williams, B A ^b   Gidley, M J ^b  

^a John L Black Consulting   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

AMPK; Ileal brake; Malonyl CoA; Melanocortin system; mTOR

Indexed keywords

EID: 84899389418     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.3921/978-90-8686-689-2     Document Type: Chapter

References (115)

1. Anderson, G.H. and Moore, S.E., 2004. Dietary proteins in the regulation of food intake and body weight in humans. The American Society for Nutritional Sciences 134: 974S-979S.
2. Anderson, G.H., Tecimer, S.N., Shah, D. and Zafar, T.A., 2004. Protein source, quantity, and time of consumption determine the effect of proteins on short-term food intake in young men. The American Society for Nutritional Sciences 134: 3011-3015.
3. Black, J.L., 2000. Amino acid and energy requirements. In: Moughan, P.J., Verstegen, M.W.A. and Visser-Reyneveld, M.I. (eds.) Feed evaluation: principles and practice. Wageningen Pers, the Netherlands, pp. 189-207.
4. Black, J.L., 2008. Premium Grains for Livestock Program, Component 1: Co-ordination. Final Report. Grains Research and Development Corporation, Canberra, Australia, 237 pp.
5. Brighenti, F., Benini, L., Del Rio, D., Casiraghi, C., Pellegrini, N., Scazzina, F., Jenkins, D.J.A. and Vantini, I., 2006. Colonic fermentation of indigestible carbohydrates contributes to the second-meal effect. American Journal of Clinical Nutrition 83: 817-822.
6. Brown, R.C., Kelleher, J. and Losowsky, M.S., 1979. The effect of pectin on the structure and function of the rat small intestine. British Journal of Nutrition 42: 357-365.
7. Burdyga, G., de Lartigue, G., Raybould, H.E., Morris, R, Dimaline, R., Varro, A., Thompson, D.G. and Dockray, G.J., 2008. Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurons serving the stomach. Journal of Neuroscience 28: 11583-11592.
8. Cadogan, D.J., Choct, M., Campbell, R.G. and Kershaw, S., 1999. Effects of new season's wheat on the growth performance of young pigs. In: Cranwell, P.D. (ed.) Manipulating pig production VII. Australian Pig Sciences Association, Werribee Victoria, Australia. p. 40.
9. Campbell, R.G., 1988. Nutritional constraints to lean tissue accretion in farm animals. Nutrition Research Reviews 1: 233-253.
10. Carroll, J.A. and Allee, G.L., 2009. Hormonal control of feed intake in swine. In: Torrallardona, D. and Roura, E. (eds.) Voluntary feed intake in pigs. Wageningen Academic Publishers, the Netherlands, pp. 155-187.
11. Catania, A., 2007. The melanocortin system in leukocyte biology. Journal of Leukocyte Biology 81: 383-392.
12. Catania, A., Lipton, J.M., Airaghi, L., Manfredi, M.G., Vivirito, M.C., Milazzo, F. and Zanussi, C., 1991. The neuropeptide alpha-MSH and other POMC-derivatives in patients with acquired immunodeficiency syndrome. International Conference on AIDS 7: 286 (Abstract).
13. Cha, S.H., Hu, Z. and Lane, M.D., 2004. Long-term effects of a fatty acid synthase inhibitor on obese mice: food intake, hypothalamic neuropeptides, and UCP3. Biochemical and Biophysical Research Communications 317: 301-308.
14. Chaudhri, O.B., Salem, V., Murphy, K.G. and Bloom, S.R., 2008. Gastrointestinal satiety signals. Annual Review of Physiology 70: 239-255.
15. Chaudhri, O., Small, C. and Bloom, S., 2006. Gastrointestinal hormones regulating appetite. Philosophical Transactions of the Royal Society B: Biological Sciences 361(1471): 1187-1209.
16. Chen, T.S., Doong, M.L., Wang, S.W., Tsai, S.C., Lu, C.C., Shih, H.C., Chen, Y.H., Chang, F.Y., Lee, S.D. and Wang, P.S., 1997. Gastric emptying and gastrointestinal transit during lactation in rats. American Journal of Physiology Gastrointestinal and Liver Physiology 272: G626-G631.
17. Clement, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.M., Basdevant, A., Bougneres, P., Lebouc, Y., Froguel, P. and Guy-Crand, B., 1998. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392: 330-331.
18. Considine, R.V., Sinha, M.K., Heiman, M.L., Kriauciunas, A., Stephens, T.W., Nyce, M.R., Ohannesian, J.P., Marco, C.C., McKee, L.J, Bauer, T.L. and Caro, J.F., 1996. Serum immunoreactive-leptin concentrations in normal-weight and obsess humans. New England Journal of Medicine 334: 292-295.
19. Cota, D., Proulx, K., Blake Smith, K.A., Kozma, S.C., Thomas, G., Woods, S.C. and Seeley, R.J., 2006. Hypothalamic mTOR signalling regulates food intake. Science 312: 927-930.
20. Couce, M.E., Cottam, D., Esplen, J., Teijeiro, R, Schauer, P. and Burguera, B., 2006. Potential role of hypothalamic ghrelin in the pathogenesis of human obesity. Journal of Endocrinological Investigations 29: 599-605.
21. Cripps, A.W. and Williams, V.J., 1975. The effect of pregnancy and lactation on food intake, gastrointestinal anatomy and the absorptive capacity of the small intestine in the albino rat. British Journal of Nutrition 33: 17-32.
22. Cuche, G., Cuber, J.C. and Malbert, C.H., 2000. Ileal short-chain fatty acids inhibit motility by a humoral pathway. American Journal of Physiology Gastrointestinal and Liver Physiology 279: G925-G930.
23. Cummings, D.E., 2006. Ghrelin and the short-and long-term regulation of appetite and body weight. Physiology and Behavior 89: 71-84.
24. Dowell, P., Hu, Z. and Lane, M.D., 2005. Monitoring energy balance: metabolites of fatty acid synthesis as hypothalamic sensors. Annual Review of Biochemistry 74: 515-534.
25. Farooqi, I.S., Jebb, S.A., Langmack, G., Lawrence, E., Cheetham, C.H., Prentice, A.M., Hughes, I.A., McCamish, M.A. and O'Rahilly, S., 1999. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. New England Journal of Medicine 341: 879-884.
26. Fleming, S.E. and Lee, B., 1983. Growth performance and intestinal transit time of rats fed purified and natural fibers. Journal of Nutrition 113: 592-601.
27. Fone, D.R., Horowitz, M., Read, N.W., Dent, J. and Maddox, A., 1990. The effects of terminal ileal triglyceride infusion on gastroduodenal motility and the intragastric distribution of a solid meal. Gastroenterology 98: 568-575.
28. Fong, Y., Moldawer, L.L., Marano, M., Wei, H., Barber, A., Manogue, K., Tracey, K.J., Kuo, G., Fischman, D.A., Cerami, A. and Lowry, S.F., 1989. Cachectin/TNF or IL-1 alpha induces cachexia with redistribution of body proteins. American Journal of Physiology Regulatory Integrative Comparative Physiology 256: R659-R665.
29. Geiser, F., Kortner, G. and Schmidt, I., 1998. Leptin increases energy expenditure of a marsupial by inhibition of daily torpor. American Journal of Physiology Regulatory Integrative Comparative Physiology 275: R1627-R1632.
30. Geliebter, A., 1988. Gastric distension and gastric capacity in relation to food intake in humans. Physiology and Behavior 44: 665-668.
31. Gidenne, T., 1992. Effect of fibre level, particle size and adaptation period on the digestibility and rate of passage as measured at the ileum and in the faeces in the adult rabbit. British Journal of Nutrition 7: 133-146.
32. Gonyou, H.W., Christopherson, R.J. and Young B.A., 1979. Effects of cold temperatures and winter conditions on some aspects of behaviour of feedlot cattle. Applied Animal Ethology 5: 113-124.
33. Gue, M., Fioramonti, J. and Bueno, L., 1987. Comparative influences of acoustic and cold stress on gastrointestinal transit in mice. Journal of Physiology Gastrointestinal and Liver Physiology 253: G124-G128.
34. Halaas, J.L., Gajiwala, K.S., Maffei, M., Cohen, S.L., Chait, B.T., Rabinowitz, D., Lallone, R.L., Burley, S.K. and Friedman, J.M., 1995. Weight-inducing effects of the plasma protein encoded by the obsess gene. Science 269: 543-546.
35. Hara, H., Nishikawa, H. and Kiriyama, S., 1992. Different effects of casein and soyabean protein on gastric emptying of protein and small intestinal transit after spontaneous feeding of diets in rats. British Journal of Nutrition 68: 59-66.
36. Hardie, D.G., Hawley, S.A. and Scott, J.W., 2006. AMP-activated protein kinase-development of the energy sensor concept. Journal of Physiology 574: 7-15.
37. Havel, P.J., 2004. Update on adipocyte hormones-regulation of energy balance and carbohydrate/lipid metabolism. Diabetes 53: 143-151.
38. Heyer A. and Lebret B., 2007. Compensatory growth response in pigs: Effects on growth performance, composition of weight gain at carcass and muscle levels, and meat quality. Journal of Animal Science 85: 769-778.
39. Hu, Z., Cha, S.H., Chohnan,S. and Lane, M.D., 2003. Hypothalamic malonyl-CoA as a mediator of feeding behaviour. Proceedings of the National Academy of Sciences of the USA 100: 12624-12629.
40. Huang, Q-H., Hruby, V.J.. and Tatro, J.B., 1999. Role of central melanocortins in endotoxin-induced anorexia. American Journal of Physiology Regulatory Integrative Comparative Physiology 276: R864-R871.
41. Huge, A., Weber, E. and Ehrlein, H-J., 1995. Effects of enteral feedback inhibition on motility, luminal flow, and absorption of nutrients in proximal gut of minipigs. Digestive Diseases and Sciences 40: 1024-1034.
42. Jenkins, D.J.A., Wolever, T.M.S., Leeds, A.R., Gassull,M.A., Haisman, P., Dilawari, J., Goff, D.V., Metz, G.L. and Alberti, K.G.M.M., 1978. Dietary fibres, fibre analogues and glucose tolerance: importance of viscosity. British Medical Journal 1: 1392-1394.
43. Karaki, S., Mitsui, R., Hayashi, H., Kato, I., Sugiya, H., Iwanaga, T., Furness, J.B. and Kuwahara, A., 2006. Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell and Tissue Research 324: 353-360.
44. Keeling, W.F. and Martin, B.J., 1987. Gastrointestinal transit during mild exercise. American Journal of Applied Physiology 63: 978-981.
45. Keller, J., Holst, J.J. and Layer, P., 2006. Inhibition of human pancreatic and biliary output but not intestinal motility by physiological intraileal lipid loads. Journal of Physiology Gastrointestinal and Liver Physiology 290: G704-G709.
46. Kendall, G.P.N., Tompson, D.G. and Day, S.J., 1987. Motor responses of the small intestines to intraluminal distension in normal volunteers and a patient with visceral neuropathy. Gut 28: 714-720.
47. Kim, E.H., Miller, I., Aja, S., Landree, L.E., Pinn, M., McFadden, J., Kuhajda, F.P., Moram, T.H. and Ronnett, G.V., 2004. C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase. Journal of Biological Chemistry 279: 19970-19976.
48. Kirsch, R., Ouarour, A. and Pevet, P., 1991. Daily torpor in the Djungarian hamster (Phodopus sungorus): photoperiod regulation, characteristics and circadian organization. Journal of Comparative Physiology A 168: 121-128.
49. Knap, P.W., 2009. Voluntary feed intake and pig breeding. In: Torrallardona, D. and Roura, E. (eds.) Voluntary feed intake in pigs. Wageningen Academic Publishers, the Netherlands, pp. 13-35.
50. Kola, B., Hubina, E., Tucci, S.A., Kirkham, T.C., Garcia, E.A., Mitchell, S.E., Williams, L.M., Hawley, S.A., Hardie, D.G., Grossman, A.B. and Korbonits, M., 2005. Cannabinoids and ghrelin have central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. Journal of Biological Chemistry 280: 25196-25201.
51. Koopmans, H.S., 1990. The role of the ileum in the control of food intake and intestinal adaptation. Canadian Journal of Physiology and Pharmacology 68: 650-655.
52. Kyriazakis, I. and Emmans, G.C., 1995. The voluntary feed intake of pigs given feeds based on wheat bran, dried citrus pulp and grass meal in relation to measurements of feed bulk. British Journal of Nutrition 73: 191-207.
53. Ledikwe, J.H., Blanck, H.M., Khan, K., Serdula, M.K., Seymour, J.D, Tohill, B.C. and Rolls, B.J., 2006. Dietary energy density is associated with energy intake and weight status in US adults. American Journal of Clinical Nutrition 83: 1362-1368.
54. Lewis, S.J. and Heaton, K.W., 1997. Increasing butyrate concentration in the distal colon by accelerating intestinal transit. Gut 41: 245-251.
55. L'Heureux-Bouron, D., Tome, D., Rampin, O., Even, P.C., Larue-Achagiotis, C. and Fromentin, G., 2003. Total subdiaphramatic vagotomy does not suppress high protein diet-induced food intake depression in rats. Journal of Nutrition 133: 2639-2642.
56. Lin, H.C., Kim, B.H., Elashoff, J.D., Doty, J.E., Gu, Y.G. and Meyer, J.H., 1992. Gastric emptying of solid food is most potently inhibited by carbohydrate in the canine distal ileum. Gastroenterology 102: 793-801.
57. Lin, H.C., Perdomo, O.L. and Zhao, X.T., 2001a. Intestinal transit in dogs is accelerated by volume distension during fat-induced jejuna brake. Digestive Diseases and Sciences 46, No.1: 19-23.
58. Lin,H.C., Van Citters, G.W., Heimer, F. and Bonorris, G., 2001b. Slowing of gastrointestinal transit by oleic acid. A preliminary report of a novel, nutrient-based treatment in humans. Digestive Diseases and Sciences 46: 223-229.
59. Lin, H.C., Zhao, X-T. and Wang, L., 1997. Intestinal transit is more potently inhibited by fat in the distal (ileal brake) than in the proximal (jejuna brake) gut. Digestive Diseases and Sciences 42: 19-25.
60. Luhovyy, B.L., Akhavan, T. and Anderson, G.H., 2007. Whey proteins in the regulation of food intake and satiety. Journal of the American College of Nutrition 26, No. 6 704S-712S.
61. Maljaars, J., Peters, H.P.F. and Masclee, A.M. 2007. Review article: the gastrointestinal tract: neuroendocrine regulation of satiety and food intake. Alimentary Pharmacology and Therapeutics 26: 241-250.
62. Maljaars, P.W.J., Peters, H.P.F., Mela, D.J. and Masclee, A.A.M., 2008. Ileal brake: A sensible food target for appetite control. A review. Physiology and Behaviour 95: 271-281.
63. Marks, D.L., Ling, N. and Cone, R.D., 2001. Role of the central melanocortin system in cachexia. Cancer Research 61: 1432-1438.
64. Martin, T.L., Alquier, T., Asakura, K., Furukawa, N., Preitner, F. and Kahn, B.B., 2006. Diet-induced obesity alters amp kinase activity in hypothalamus and skeletal muscle. Journal of Biological Chemistry 281: 18933-18941.
65. Massimino, S.P., McBurney, M.I. and Field, C.J., 1998. Fermetable dietary fibre increases GLP-1 secretion and improves glucose homeostasis despite increased intestinal glucose transport capacity in healthy dogs. Journal of Nutrition 128: 1786-1793.
66. Mateos, G.G., Martin, F., Latorre, M.A., Vicente, B. and Lazaro, R., 2007. Inclusion of oat hulls in diets of young pigs based on cooked maize or cooked rice. Animal Science 82: 57-63.
67. Meyer, J.H., Elashoff, J.D., Doty, J.E. and Gu, Y.G., 1994. Disproportionate ileal digestion on canine food consumption. A possible model for satiety in pancreatic insufficiency. Digestive Diseases and Sciences 39: 1014-1024.
68. Meyer, J.H., Hlinka, M., Khatibi, A., Raybould, H.E. and Tso, P., 1998a. Role of small intestine caloric ompensations to oil premeals in rats. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 275: R1320-R1333.
69. Meyer, J.H., Hlinka, M., Tabrizi, Y., DiMaso, N. and Raybould, H.E., 1998b. Chemical specificities and intestinal distributions of nutrient-driven satiety. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 275: R1293-R1307.
70. Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y-B., Lee, Q., Xue, B., Mu, J., Foufelle, F., Ferre, P., Birnbaum, M.J., Stuck, B.J. and Kahn, B.B., 2004. AMP-kinase regulates food intake by responding to hormonal and nutrient sgnals in the hypothalamus. Nature 428: 569-574.
71. Montague, C.T., Farooqi, I.S., Whitehead, J.P., Soos, M.S., Rau, H., Wareham, N.J., Sewter, C.P., Digby, J.E., Mohammed, S.N., Hurst, J.A., Cheetham, C.H., Earley, A.R., Barnett, A.H., Prins J.B. and O'Rahilly, S., 1997. Congenital leptin deficiency is associated with severe onset of obesity in humans. Nature 387: 903-908.
72. Morgan, K., Obici, S. and Rossetti, L., 2004. Hypothalmic responses to long-chain fatty acids are nutritionally regulated. Journal of Biological Chemistry 279: 31139-31148.
73. Morrison, C.D., Xi, X., White, C.L., Ye, J. and Martin, R.J., 2007. Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism. American Journal of Physiology Endocrinology and Metabolism 293: E165-E171.
74. Myers, M.G., Cowley, M.A., and Munzburg, H., 2008. Mechanisms of leptin action and leptin resistance. Annual Review of Physiology 70: 537-556.
75. Neary, N.M., Small, C.J., Druce, M.R., Park, A.J., Ellis, S.M., Semjonous, N.M., Dakin, C.L., Filipsson, K., Wang, F., Kent, A.S., Frost, G.S., Ghatei, M.A., and Bloom, S.R., 2005. Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively. Endocrinology 146: 5120-5127.
76. Obici,S., Feng, Z., Morgan, K., Stein, D., Karkanias, G. and Rossetti, L., 2002. Central administration of oleic inhibits glucose production and food intake. Diabetes. 51: 271-275.
77. Pelz, K.M. and Dark, J., 2007. IVC NPY Y1 receptor agonist but not Y5 agonist induces torpor-likr hypothermia in cold-acclimatised Siberian hamsters. American Journal of Physiology Regualtory Integrative Comparative Physiology 292: R2299-R2311.
78. Phillips, P.A., Young, B.A. and McQuitty, J.B., 1982. Liveweight, protein deposition and digestibility responses in growing pigs exposed to low temperature. Canadian Journal of Animal Science 62: 95-108.
79. Piche, T., Varannes des, B. S., Sacher-Huvelin,S., Holst, J.J., Cuber, J.C. and Galmiche, J.P., 2003. Colonic fermentation influences lower esophageal sphincter function in gastroesophageal reflux disease. Gastroenterology 124: 894-902.
80. Pimentel, M., Lin, H.C., Enayati, P., van den Burg, B., Lee, H-R., Chen, J.H., Park, S., Kong, Y. and Conklin, J., 2006.Methane, a gas produced by enteric bacteria, slows intestinal transit and augments small intestinal contractile activity. American Journal of Physiology Gastrointestinal and Liver Physiology 290: G1089-G1095.
81. Pocai, A., Lam, T.K.T., Obici, S., Gutierrez-Juarez, R., Muse, E.D., Arduini, A. and Rossetti, L., 2006. Restoration of hypothalamic lipid sensing normalises energy and glucose homeostasis in overfed rats. Journal of Clinical Investigation 116: 1081-1091.
82. Richards, M.P. and Proszkowiec-Weglarz, M. 2007. Mechanisms regulating feed intake, energy expenditure, and body weight in poultry. Poultry Science 86: 1478-1490.
83. Roche, J.R., Blanche, D., Kay, J.K., Miller, D.R., Sheahan, A.J. and Miller, D.W., 2008. Neuroendocrine and physiological regulation of intake with particular reference to domesticated ruminant animals. Nutrition Research Reviews 21: 207-234.
84. Rolls, B.J., Bell, E.A. and Waugh, B.A., 2000. Increasing the volume of a food by incorporating air affects satiety in men. American Journal of Clinical Nutrition 72: 361-368.
85. Rolls, B.J., Castellanos, V.H., Halford, J.C., Kilara, A., Panyam, D., Plekman, C.L., Smith, G.P. and Thorwart, M.L., 1998. Volume of food consumed effects satiety in men. American Journal of Clinical Nutrition 67: 1170-1177.
86. Ropert, A., Cherbut, C., Roze, C., Le Quellec, A., Holst, J.J., Fu-Cheng, X., Varannes, des, B. S. and Galmiche, J.P., 1996. Colonic fermentation and proximal gastric tone in humans. Gastroenterology 111: 289-296.
87. Roth, J.D., Coffey, T., Jodka, C.M., Maier, H., Athanacio, J.R., Mack, C.M., Weyer, C. and Parkes, D.G., 2007. Combination therapy with amylin and peptide YY[3-36] in obese rodents: anorexigenic synergy and weight loss additivity. Endocrinology 148: 6054-6061.
88. Roth, J.D., Hughes, H., Kendall, E., Baron, A.D. and Anderson, C.M., 2006. Anti-obesity effects of the β-cell hormone amylin in diet-induced obese rats: effects on food intake, body weight, composition, energy expenditure and gene expression. Endocrinology 147: 5855-5864.
89. Roth, J.D., Roland, B.L., Cole, R.L., Trevaskis, J.L., Weyer, C., Koda, J.E., Anderson, C.M., Parkes, D.G. and Baron, A.D., 2008. Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies. Proceedings of the National Academy of Sciences of the USA 105: 7257-7262.
90. Samra, R.A. and Anderson, G.H., 2007. Insoluble cereal fiber reduces appetite and short-term food intake and glycemic response to food consumed 75 min later by healthy men. American Journal of Clinical Nutrition 86: 972-979.
91. Sandoval, D., Cota, D. and Seeley, R.J., 2007. The integrative role of CNS fuel-sensing mechanisms in energy balance and glucose regulation. Annual Review of Physiology 70: 513-535.
92. Sasaki, O., Shinohara, H., Yamagishi, T., Nishida, A. and Mizuma, Y., 1996. Application of agar-fill method to estimate compartment capacity of gastrointestinal tract in Syrian hamsters. British Journal of Nutrition 76: 833-840.
93. Shan, J., Nguyen, T.B., Totary-Jain, H., Dansky, H., Marx, S.O. and Marks, A.R., 2008. Leptin-enhanced neointimal hyperplasia is reduced by mTOR and PI3K inhibitors. Proceedings of the National Academy of Sciences of the USA 105: 19006-19011.
94. Siegle, M.L., Schmid, H.R. and Ehrlein, H.J., 1990. Effects of ileal infusions of nutrients on motor patterns of canine small intestine. American Journal of Physiology Gastrointestinal and Liver Physiology 259: G78-G85.
95. Spiller,R.C., Trotman, I.F., Adrian, T.E., Bloom, S.R., Misiewicz, J.J. and Silk, D.B.A., 1988. Further characterisation of the 'ileal brake' reflex in man-effect of ileal infusion of partial digests of fat, protein, and starch on jejunal motility and release of neurotensin, enteroglucagon, and peptide YY. Gut 29: 1042-1051.
96. Spiller,R.C., Trotman, I.F., Higgins, B.E., Ghatei, M.A., Lee, Y.C., Bloom, S.R., Misiewicz, J.J. and Silk, D.B., 1984. The ileal brake-inhibition of jejunal motility after ileal fat perfusion in man. Gut 25: 365-374.
97. Stanogias, G. amd Pearce, G.R., 1985a. The digestion of fibre by pigs. 1. The effects f amount and type of fibre on apparent digestibility, nitrogen balance and rate of passage. British Journal of Nutrition 53: 513-530.
98. Stanogias, G. amd Pearce, G.R., 1985b. The digestion of fibre by pigs. 3. Effects of the amount and type of fibre on physical characteristics of segments of the gastrointestinal tract. British Journal of Nutrition 53: 537-548.
99. Steadman, C. and Kerlin, P., 1994. Response of the human intestine to high volume infusion. Gut 35: 641-645.
100. Tso, P., Sun, W. and Liu, M., 2004. Gastrointestinal Satiety Signals IV. Apolipoprotein A-IV. American Journal of Physiology Gastrointestinal and Liver Physiology 286: G885-G890.
101. Van Thuijl, H., Kola, B. and Korbonits, M., 2008. Appetite and metabolic effects of ghrelin and cannabinoids: involvement of AMP-activated protein kinase. In: Litwack, G. (ed.) Ghrelin, Vitamins and Hormones, volume 77. Elsevier Inc. Amsterdam, the Netherlands, pp.121-148.
102. Vicente, B., Valencia, D.G., Perez-Serrano, M., Lazaro, R. and mateos, G.G., 2008. The effects of feeding rice in substitution of corn and the degree of starch gelatinisation of rice on the digestibility of dietary components and productive performance of young pigs. Journal of Animal Science 86: 119-126.
103. Vu, M.K., Nouwens, A.G., Biemond, I., Lamers, C.B.H.W. and Masclee, A.A.M., 2000. The osmotic laxative magnesium sulphate activates the ileal brake. Alimentary Pharmocology and Therapeutics 14: 587-595.
104. Wang, J., Obici, S., Morgan, K., Barzilai, N., Feng, Z. and Rossetti, L. 2001. Overfeeding rapidly induces leptin and insulin resistance. Diabetes 50: 2786-2791.
105. Welch, I.M., Cunningham, K.M. and Read N.M., 1988. Regulation of gastric emptying by ileal nutrients in humans. Gastroenterology 94: 401-404.
106. Westra, R. and Christopherson, R.J., 1976. Effects of cold on digestibility, tetention time of digesta, reticulum motility and thyroid hormones in sheep. Canadian Journal of Animal Science 56: 699-708.
107. Whited, K.L., Tso, P and Raybould. H.E., 2006. Involvement of apolipoprotein A-IV and cholecystokinin1 receptors in exogenous peptide YY3-36-induced stimulation of intestinal feedback. Endocrinology 148: 4695-4703.
108. Williams, D.L.., Baskin, D.G. and Schwartz, M.W., 2006. Leptin regulation of the anorexic response to glucagon-like peptide-1 receptor stimulation. Diabetes 55: 3387-3393.
109. Wolfgang, M.J., Cha, S.H., Sidhaye, A., Chohnan, S., Cline, G., Shulman, G.I. and Lane, M.D., 2007. Regulation of hypothalamic malonyl-CoA by central glucose and leptin. Proceedings of the National Academy of Sciences of the USA 104: 19285-19290.
110. Wondra, K.J., Hancock, J.D., Behnke, K.C. and Stark, C.R., 1995. Effects of mill type and particle size uniformity on growth performance, nutrient digestibility, and stomach morphology in finishing pigs. Journal of Animal Science 73: 3564-2573.
111. Woods, S.C., Benoit, S.C. and Clegg, D.J., 2006. The brain-gut-islet connection. Diabetes 55: S114-S121.
112. Woods, S.C., D'Alessio, D.A., Tso, P., Rushing, P.A., Clegg, D.J., Benoit, S.C., Gotoh, K., Liu, M. and Seeley, R.J., 2004. Consumption of a high-fat diet alters the homeostatic regulation of energy balance. Physiology and Behavior 83: 573-578.
113. Woods, S.C., Lotter, E.C., McKay, D. and Porte D. Jr., 1979. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature 282: 503-505.
114. Woods, S.C., Seeley, R.J. and Cota, D., 2008. Regulation of food intake through hypothalamic signaling networks involving mTOR. Annual Review of Nutrition 28: 295-311.
115. Wullschleger, S., Loewith, R. and Hall, M.N., 2006. TOR signalling in growth and metabolism. Cell 124: 471-484.