Hormonal control of feed intake in swine

Voluntary Feed Intake in Pigs

Volumn , Issue , 2009, Pages 155-187

  Carroll, J A ^a   Allee, G L ^b  

^a U S DEPARTMENT OF AGRICULTURE   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

Appetite; Glucocorticoids; Neuropeptides; Somatotrophic axis

Indexed keywords

EID: 84875243238     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.3921/978-90-8686-689-2     Document Type: Chapter

References (162)

1. Adam, C.L., Archer, Z.A., Findlay, P.A., Thomas, L. and Marie, M. 2002. Hypothalamic gene expression in sheep for cocaine-and amphetamine-regulated transcript, pro-opiomelanocortin, neuropeptide Y, agouti-related peptide and leptin receptor and responses to negative energy balance. Neuroendocrinology 75: 250-256.
2. Arvat, E., Maccario, M., Di, V.L., Broglio, F., Benso, A., Gottero, C., Papotti, M., Muccioli, G., Dieguez, C., Casanueva, F.F., Deghenghi, R., Camanni, F. and Ghigo, E., 2001. Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. Journal of Clinical Endcrinology and Metabolism 86: 1169-1174.
3. Asakawa, A., Inui, A., Kaga, T., Yuzuriha, H., Nagata, T., Fujimiya, M., Katsuura, G., Makino, S., Fujino, M.A. and Kasuga, M. 2001a. A role of ghrelin in neuroendocrine and behavioral responses to stress in mice. Neuroendocrinology 74: 143-147.
4. Asakawa, A., Inui, A., Kaga, T., Yuzuriha, H., Nagata, T., Ueno, N., Makino, S., Fujimiya, M., Niijima, A., Fujino, M.A. and Kasuga, M. 2001b. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120: 337-345.
5. Atinmo, T., Baldijao, C., Houpt, K.A., Pond, W.G. and Barnes, R.H., 1978. Plasma levels of growth hormone and insulin in protein malnourished vs normal growing pigs in response to arginine or glucose infusion. Journal of Animal Science 46: 409-416.
6. Barb, C.R., Hausman, G.J. and Houseknecht, K.L., 2001. Biology of leptin in the pig. Domestic Animal Endocrinology 21: 297-317.
7. Barb, C.R., Kraeling, R.R., Rampacek, G.B. and Hausman, G.J., 2006. The role of neuropeptide Y and interaction with leptin in regulating feed intake and luteinizing hormone and growth hormone secretion in the pig. Reproduction 131: 1127-1135.
8. Barb, C.R., Yan, X., Azain, M.J., Kraeling, R.R., Rampacek, G.B. and Ramsay, T.G., 1998. Recombinant porcine leptin reduces feed intake and stimulates growth hormone secretion in swine. Domestic Animal Endocrinology 15: 77-86.
9. Berelowitz, M., Firestone, S.L. and Frohman, L.A., 1981. Effects of growth hormone excess and deficiency on hypothalamic somatostatin content and release and on tissue somatostatin distribution. Endocrinology 109: 714-719.
10. Bidwell, C.A., Ji, S., Frank, G.R., Cornelius, S.G. and Willis, G.M., 1997. Cloning and expression of the porcine obese gene. Animal Biotechnology 8: 191-206.
11. Billington, C.J., Briggs, J.E., Grace, M. and Levine, A.S., 1991. Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism. The American Journal of Physiology 260: R321-R327.
12. Booth, P.J., Craigon, J., Foxcroft, G.R., 1994. Nutritional manipulation of growth and metabolic and reproductive status in prepubertal gilts. Journal of Animal Science 72: 2415-2424.
13. Brady, L.S., Smith, M.A., Gold, P.W. and Herkenham, M., 1990. Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology 52: 441-447.
14. Breier, B.H. and Gluckman, P.D., 1991. The regulation of postnatal growth: nutritional influences on endocrine pathways and the function of the somatotrophic axis. Livestock Production Science 27: 77-94.
15. Broglio, F., Gottero, C., Prodam, F., Destefanis, S., Gauna, C., Me, E., Riganti, F., Vivenza, D., Rapa, A., Martina, V., Arvat, E., Bona, G., van der Lely, A.J. and Ghigo, E. 2004. Ghrelin secretion is inhibited by glucose load and insulin-induced hypoglycaemia but unaffected by glucagon and arginine in humans. Clinincal Endocrinology 61: 503-509.
16. Buonomo, F.C., Grohs, D.L. Baile, C.A. and Campion, D.R,, 1988. Determination of circulating levels of insulin-like growth factor II (IGF-II) in swine. Domestic Animal Endocrinology 5: 323-329.
17. Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R. and Burn, P., 1995. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549.
18. Carroll, J.A., 2001. Dexamethasone treatment at birth enhances neonatal growth in swine. Domestic Animal Endocrinology 21: 97-109.
19. Carroll, J.A., Buonomo, F.C., Becker, B.A. and Matteri, R.L., 1999. Interactions between environmental temperature and porcine growth hormone (pGH) treatment in neonatal pigs. Domestic Animal Endocrinology 16: 103-113.
20. Carroll, J.A., Daniel, J.A., Keisler, D.H. and Matteri, R.L., 2000. Postnatal function of the somatotrophic axis in pigs born naturally or by Caesarian section. Domestic Animal Endocrinology 19: 39-52.
21. Carroll, J.A., Veum, T.L. and Matteri, R.L., 1998. Endocrine responses to weaning and changes in postweaning diet in the young pig. Domestic Animal Endocrinology 15: 183-194.
22. Cavagnini, F., Croci, M., Putignano, P., Petroni, M.L. and Invitti, C., 2000. Glucocorticoids and neuroendocrine function. International Journal of Obesity and Related Metabolic Disorders 24 (Suppl. 2): S77-S79.
23. Chen, H., Charlat, O., Tartaglia, L.A., Woolf, E.A., Weng, X., Ellis, S.J., Lakey, N.D., Culpepper, J., Moore, K.J., Breitbart, R.E., Duyk, G.M., Tepper, R.I. and Morgenstern, J.P., 1996. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84: 491-495.
24. Coffey, R.D. and Cromwell, G.L., 1995. The impact of environment and antimicrobial agents on the growth response of early-weaned pigs to spray-dried porcine plasma. Journal of Animal Science 73: 2532-2539.
25. Colmers, W.F. and El, B.B., 2003. Neuropeptide Y and epilepsy. Epilepsy Currents 3: 53-58.
26. Crooker, B.A., McGuire, M.A., Cohick, W.S., Harkins, M., Bauman, D.E. and Sejrsen, K., 1990. Effect of dose of bovine somatotropin on nutrient utilization in growing dairy heifers. Journal of Nutrition 120: 1256-1263.
27. Cummings, D.E., Purnell, J.Q., Frayo, R.S., Schmidova, K., Wisse, B.E. and Weigle, D.S., 2001. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50: 1714-1719.
28. Cuntz, U., Leibbrand, R., Ehrig, C., Shaw, R. and Fichter, M.M., 2001. Predictors of post-treatment weight reduction after in-patient behavioral therapy. International Journal of Obesity and Related Metabolic Disorders 25 (Suppl 1): S99-S101.
29. Daniel, J.A., Whitlock, B.K., Wagner, C.G. and Sartin, J.L., 2002. Regulation of the growth hormone and luteinizing hormone response to endotoxin in sheep. Domestic Animal Endocrinology 23: 361-370.
30. Dauncey, M.J. and Morovat, A. 1993. Investigation of mechanisms mediating the increase in plasma concentrations of thyroid hormones after a meal in young growing pigs. Journal of Endocrinology 139: 131-141.
31. De Rodas, B.Z., Sohn, K.S., Maxwell, C.V. and Spicer, L.J., 1995. Plasma protein for pigs weaned at 19 to 24 days of age: effect on performance and plasma insulin-like growth factor I, growth hormone, insulin, and glucose concentrations. Journal of Animal Science 73: 3657-3665.
32. Dhillo WS, Small CJ, Stanley SA, Jethwa PH, Seal LJ, Murphy KG, Ghatei MA, Bloom SR. 2002. Hypothalamic interactions between neuropeptide Y, agouti-related protein, cocaine-and amphetamineregulated transcript and alpha-melanocyte-stimulating hormone in vitro in male rats. Journal of Neuroendocrinology 14: 725-730.
33. Dyer, C.J., Touchette, K.J., Carroll, J.A., Allee, G.L. and Matteri, R.L., 1999. Cloning of porcine prepro-orexin cDNA and effects of an intramuscular injection of synthetic porcine orexin-B on feed intake in young pigs. Domestic Animal Endocrinology 16: 145-148.
34. Edwards, C.M., Abusnana, S., Sunter, D., Murphy, K.G., Ghatei, M.A. and Bloom, S.R., 1999. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. Journal of Endocrinology 160: R7-12.
35. Eisemann, J.H., Hammond, A.C., Bauman, D.E., Reynolds, P.J., McCutcheon, S.N., Tyrrell, H.F. and Haaland, G.L., 1986. Effect of bovine growth hormone administration on metabolism of growing Hereford heifers: protein and lipid metabolism and plasma concentrations of metabolites and hormones. Journal of Nutrition 116: 2504-2515.
36. Eisemann, J.H., Hammond, A.C. and Rumsey, T.S., 1989. Tissue protein synthesis and nucleic acid concentrations in steers treated with somatotropin. British Journal of Nutrition 62: 657-671.
37. Elias, C.F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R.S., Bjorbaek, C., Flier, J.S., Saper, C.B. and Elmquist, J.K., 1999. Leptin differentially regulates NPY and POMC neurons proecting to the lateral hypothalamic area. Neuron 23: 775-786.
38. Elsasser, T.H., Rumsey, T.S., Hammond, A.C. and Fayer, R., 1988. Influence of parasitism on plasma concentrations of growth hormone, somatomedin-C and somatomedin-binding proteins in calves. Journal of Endocrinology 116: 191-200.
39. Farmer, C., Petitclerc, D., Pelletier, G., Gaudreau, P. and Brazeau, P., 1992. Carcass composition and resistance to fasting in neonatal piglets born of sows immunized against somatostatin and/or receiving growth hormone-releasing factor injections during gestation. Biology of the Neonate 61: 110-117.
40. Forbes, J.M., 1995. Voluntary food intake and diet selection in farm animals. CAB International, Wallingford.
41. Funderburke, D.W. and Seerley, R.W., 1990. The effects of postweaning stressors on pig weight change, blood, liver and digestive tract characteristics. Journal of Animal Science 68: 155-162.
42. Gaines, A.M., Carroll, J.A. and Allee, G.L., 2004. Evaluation of exogenous glucocorticoid injection on preweaning growth performance of neonatal pigs under commercial conditions. Journal of Animal Science 82: 1241-1245.
43. Gaines, A.M., Carroll, J.A. Allee, G.L. and Yi, G.F., 2002. Pre-and postweaning performance of pigs injected with dexamethasone at birth. Journal of Animal Science 80: 2255-2262.
44. Gaytan, F., Barreiro, M.L., Chopin, L.K., Herington, A.C., Morales, C., Pinilla, L., Casanueva, F.F., Aguilar, E., Diéguez, C. and Tena-Sempere, M., 2003. Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary. Journal of Clinical Endocrinololgy and Metabolism 88: 879-887.
45. Georgsson, L. and Svendsen, J., 2002. Degree of competition at feeding differentially affects behavior and performance of group-housed growing-finishing pigs of different relative weights. Journal of Animal Science 80: 376-383.
46. Giroux, S., Martineau, G. and Robert, S., 2000. Relationships between individual behavioural traits and post-weaning growth in segregated early-weaned piglets. Applied Animal Behaviour Science 70: 41-48.
47. Govoni, N., De Iasio, R., Cocco, C., Parmeggiani, A., Galeati, G., Pagotto, U., Brancia, C., Spinaci, M., Tamanini, C., Pasquali, R., Ferri, G.L. and Seren, E., 2005. Gastric immunolocalization and plasma profiles of acyl-ghrelin in fasted and fasted-refed prepuberal gilts. Journal of Endocrinology 186: 505-513.
48. Graham, M., Shutter, J.R., Sarmiento, U., Sarosi, I. and Stark, K.L., 1997. Overexpression of Agrt leads to obesity in transgenic mice. Nature Genetics 17: 273-274.
49. Green, H., Morikawa, M. and Nixon, T., 1985. A dual effector theory of growth-hormone action. Differentiation 29: 195-198.
50. Hahn, T.M., Breininger, J.F., Baskin, D.G. and Schwartz, M.W., 1998. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nature Neuroscience 1: 271-272.
51. Harrell, R.J., Thomas, M.J., Boyd, R.D., Czerwinski, S.M., Steele, N.C. and Bauman, D.E., 1999. Ontogenic maturation of the somatotropin/insulin-like growth factor axis. Journal of Animal Science 77: 2934-2941.
52. Hart, I.C. and Johnsson, I.D., 1986. Growth hormone and growth in meat producing animals. In: P.J. Buttery, D.B. Lindsay and N.B. Haynes (eds.) Control and Manipulation of Animal Growth. Buttersworths, London, pp. 135-159.
53. Harvey, S., 1995. Growth hormone release: Mechanisms. In: S. Harvey, C.G. Scanes and W. H. Daughaday (eds.) Growth hormone, CRC Press, Inc., Boca Raton.
54. Hattori, N., Saito, T., Yagyu, T., Jiang, B.H., Kitagawa, K. and Inagaki, C., 2001. GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils. Journal of Clinical Endocrinololgy and Metabolism 86: 4284-4291.
55. Hattori, N., Shimatsu, A., Sugita, M., Kumagai, S. and Imura, H. 1990. Immunoreactive growth hormone (GH) secretion by human lymphocytes: augmented release by exogenous GH. Biochemimcal and Biophysical Research Communications 168: 396-401.
56. Hellstern, G., Reijngoud, D.J., Stellaard, F. and Okken, A., 1996. Insulin-like growth factor-I fails to reverse corticosteroid-induced protein catabolism in growing piglets. Pediatric Research 39: 421-426.
57. Henry, B.A., 2003. Links between the appetite regulating systems and the neuroendocrine hypothalamus: lessons from the sheep. Journal of Neuroendocrinology 15: 697-709.
58. Hevener, W., Almond. G.W., Armstrong. J.D. and Richards, R.G., 1997. Effects of acute endotoxemia on serum somatotropin and insulin-like growth factor I concentrations in prepubertal gilts. Americal Journal of Veterinary Research 58: 1010-1013.
59. Houseknecht, K.L. and Portocarrero, C.P., 1998. Leptin and its receptors: regulators of whole-body energy homeostasis. Domestic Animal Endocrinology 15: 457-475.
60. Ingalls, A.M., Dickie, M.M. and Snell, G.D., 1950. Obese, a new mutation in the house mouse. Journal of Heridity 41: 317-318.
61. Inoue, H., Watanuki, M., Myint, H.T., Ito, T., Kuwayama, H. and Hidari, H., 2005. Effects of fasting and refeeding on plasma concentrations of leptin, ghrelin, insulin, growth hormone and metabolites in swine. Animal Science Journal 76: 367-374.
62. Jain, M.R, Pu, S., Kalra, P.S. and Kalra, S.P., 1999. Evidence that stimulation of two modalities of pituitary luteinizing hormone release in ovarian steroid-primed ovariectomized rats may involve neuropeptide Y Y1 and Y4 receptors. Endocrinology 140: 5171-5177.
63. Kato, Y., Ishikawa, K., Ieiri, T., Imai, K. and Suzuki, M., 1989. Pituitary concentration of GH messenger ribonucleic acid in rats with anterolateral hypothalamic deafferentation. Endocrinologia Japonica. 36: 87-93.
64. Kattesh, H.G., Charles, S.F., Baumbach, G.A. and Gillespie, B.E., 1990. Plasma cortisol distribution in the pig from birth to six weeks of age. Biology of the Neonate 58: 220-226.
65. Kelley, K.W., 1989. Growth hormone, lymphocytes and macrophages. Biochemical Pharmacology 38: 705-713.
66. Kirchgessner, A.L., 2002. Orexins in the brain-gut axis. Endocrine Reviews 23: 1-15.
67. Kojima, C.J., Carroll, J.A., Matteri, R.L., Touchette, K.J. and Allee, G.L., 2007. Effects of weaning and weaning weight on neuroendocrine regulators of feed intake in pigs. Journal of Animal Science 85: 2133-2139.
68. Korbonits, M., Bustin, S.A., Kojima, M., Jordan, S., Adams, E.F., Lowe, D.G., Kangawa, K. and Grossman, A.B., 2001. The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. Journal of Clinical Endocrinololgy and Metabolism 86: 881-887.
69. Kozicz, T., Yanaihara, H. and Arimura, A., 1998. Distribution of urocortin-like immunoreactivity in the central nervous system of the rat. Journal of Comparitive Neurology 391: 1-10.
70. Kuenzel, W.J., Douglass L.W. and Davison, B.A., 1987. Robust feeding following central administration of neuropeptide Y or peptide YY in chicks, Gallus domesticus. Peptides 8: 823-828.
71. Lee, C.Y., Bazer, F.W., Etherton, T.D. and Simmen, F.A., 1991. Ontogeny of insulin-like growth factors (IGF-I and IGF-II) and IGF-binding proteins in porcine serum during fetal and postnatal development. Endocrinology 128: 2336-2344.
72. Lee, G.H., Proenca, R., Montez, J.M., Carroll, K.M., Darvishzadeh, J.G., Lee, J.I. and Friedman, J.M., 1996. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379: 632-635.
73. Li, J., Owens, J.A., Owens, P.C., Saunders, J.C., Fowden, A.L. and Gilmour, R.S., 1996. The ontogeny of hepatic growth hormone receptor and insulin-like growth factor I gene expression in the sheep fetus during late gestation: developmental regulation by cortisol. Endocrinology 137: 1650-1657.
74. Malendowicz, W., Rucinski, M., Macchi, C., Spinazzi, R., Ziolkowska, A., Nussdorfer, G.G. and Kwias, Z., 2006. Leptin and leptin receptors in the prostate and seminal vesicles of the adult rat. International Journal of Molecular Medicine 18: 615-618.
75. Margetic, S., Gazzola, C., Pegg, G.G. and Hill, R.A., 2002. Leptin: a review of its peripheral actions and interactions. International Journal of Obesity and Related Metabolic Disorders 26: 1407-1433.
76. Matteri, R.L., Dyer, C.J., Touchette, K.J., Carroll, J.A. and Allee, G.L., 2000. Effects of weaning on somatotrophic gene expression and circulating levels of insulin-like growth factor-1 (IGF-1) and IGF-2 in pigs. Domestic Animal Endocrinology 19: 247-259.
77. Matteri, R.L., Lamberson, W.R. and Keisler, D.H., 1994. Relationship between in vitro somatotroph function and growth in three-week-old barrows. Domestic Animal Endocrinology 11: 363-373.
78. McAtee, J.W. and Trenkle, A., 1971. Effect of feeding, fasting and infusion of energy substrates on plasma growth hormone levels in cattle. Journal of Animal Science 33: 612-616.
79. McLaughlin CL, Rogan GJ, Buonomo FC, Cole WJ, Hartnell GF, Hudson S, Kasser TR, Miller MA, Baile CA. 1991. Finishing lamb performance responses to bovine and porcine somatotropins administered by Alzet pumps. Journal of Animal Science 69: 4039-4048.
80. McMahon, C.D., Buxton, D.F., Elsasser, T.H., Gunter, D.R., Sanders, L.G., Steele, B.P. and Sartin, J.L., 1999. Neuropeptide Y restores appetite and alters concentrations of GH after central administration to endotoxic sheep. Journal of Endocrinology 161: 333-339.
81. McShane, T.M., May, T., Miner, J.L. and Keisler, D.H., 1992. Central actions of neuropeptide-Y may provide a neuromodulatory link between nutrition and reproduction. Biology of Reproduction 46: 1151-1157.
82. McShane, T.M., Petersen, S.L., McCrone, S. and Keisler, D.H., 1993. Influence of food restriction on neuropeptide-Y, proopiomelanocortin, and luteinizing hormone-releasing hormone gene expression in sheep hypothalami. Biology of Reproduction 49: 831-839.
83. Miell, J.P., Buchanan, C.R., Norman, M.R., Maheshwari, H.G, and Blum, W.F., 1994. The evolution of changes in immunoreactive serum insulin-like growth factors (IGFs), IGF-binding proteins, circulating growth hormone (GH) and GH-binding protein as a result of short-term dexamethasone treatment. Journal of Endocrinology 142: 547-554.
84. Miell, J.P., Taylor, A.M., Jones, J., Holly, J.M., Gaillard, R.C., Pralong, F.P., Ross, R.J. and Blum, W.F., 1993. The effects of dexamethasone treatment on immunoreactive and bioactive insulin-like growth factors (IGFs) and IGF-binding proteins in normal male volunteers. Journal of Endocrinology 136: 525-533.
85. Miller, T.L. and Mayo K.E., 1997. Glucocorticoids regulate pituitary growth hormone-releasing hormone receptor messenger ribonucleic acid expression. Endocrinology 138: 2458-2465.
86. Miner, J.L., Della-Fera, M.A., Paterson, J.A. and Baile, C.A., 1989. Lateral cerebroventricular injection of neuropeptide Y stimulates feeding in sheep. American Journal of Physiology 257: R383-R387.
87. Mizuno, T.M. and Mobbs, C.V.. 1999. Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology 140: 814-817.
88. Molitch, M.E. and Hlivyak, L.E., 1980. Growth hormone short-loop feedback: anatomic specificity of growth hormone stimulation of hypothalamic somatostatin concentration. Hormone and Metabolic Research 12: 559-560.
89. Mori, K., Yoshimoto, A., Takaya, K., Hosoda, K., Ariyasu, H., Yahata, K., Mukoyama, M., Sugawara, A., Hosoda, H., Kojima, M., Kangawa, K. and Nakao, K., 2000. Kidney produces a novel acylated peptide, ghrelin. FEBS Letters 486: 213-216.
90. Moseley, W.M., Paulissen, J.B., Goodwin, M.C., Alaniz, G.R. and Claflin, W.H., 1992. Recombinant bovine somatotropin improves growth performance in finishing beef steers. Journal of Animal Science 70: 412-425.
91. Muller, E.E., 1987. Neural control of somatotropic function. Physiological Revievs 67: 962-1053.
92. Muroya, S., Funahashi, H., Yamanaka, A., Kohno, D., Uramura, K., Nambu, T., Shibahara, M., Kuramochi, M., Takigawa, M., Yanagisawa, M., Sakurai, T., Shioda, S. and Yada, T., 2004. Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus. European Journal of Neuroscience 19: 1524-1534.
93. Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K. and Matsukura, S., 2001. A role for ghrelin in the central regulation of feeding. Nature 409: 194-198.
94. Nogami, H., Inoue, K. and Kawamura, K., 1997. Involvement of glucocorticoid-induced factor(s) in the stimulation of growth hormone expression in the fetal rat pituitary gland in vitro. Endocrinology 138: 1810-1815.
95. Nogami, H. and Tachibana, T., 1993. Dexamethasone induces advanced growth hormone expression in the fetal rat pituitary gland in vivo. Endocrinology 132: 517-523.
96. Novakofski, J. and McCusker, R.H., 1993. Physiology and principles of muscle growth. In: Hollis, G.R. (ed.) Growth of the pig. CAB International, Wallingford.Pages, pp 33-48.
97. Owens, P.C., Campbell, R.G., Francis, G.L. and Quinn, K.J., 1994. Growth hormone, gender and insulin-like growth factors: relationship to growth performance in pigs. Journal of Animal Science (Suppl. 1): 253.
98. Palmiter, R.D., Erickson, J.C., Hollopeter, G., Baraban, S.C. and Schwartz, M.W., 1998. Life without neuropeptide Y. Recent Progress in Hormonal Research 53: 163-199.
99. Parkes, D.G., Vaughan, J., Rivier, J., Vale, W. and May, C.N., 1997. Cardiac inotropic actions of urocortin in conscious sheep. American Journal of Physiology 272: H2115-H2122.
100. Parrott, R.F., Heavens, R.P. and Baldwin, B.A., 1986. Stimulation of feeding in the satiated pig by intracerebroventricular injection of neuropeptide Y. Physiology and Behavior 36: 523-525.
101. Parrott, R.F., Vellucci, S.V., Goode, J.A., Lloyd, D.M. and Forsling, M.L., 1995. Cyclo-oxygenase mediation of endotoxin-induced fever, anterior and posterior pituitary hormone release, and hypothalamic c-Fos expression in the prepubertal pig. Experimental Physiology 80: 663-674.
102. Pelleymounter, M.A., Cullen, M.J., Baker, M.B., Hecht, R., Winters, D., Boone, T. and Collins, F., 1995. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543.
103. Phillips, L.S., 1986. Nutrition, somatomedins, and the brain. Metabolism 35: 78-87.
104. Phillips, M.S., Liu, Q., Hammond, H.A., Dugan, V., Hey, P.J., Caskey, C.J. and Hess, J.F., 1996. Leptin receptor missense mutation in the fatty Zucker rat. Nature Genetics 13: 18-19.
105. Plotsky, P.M. and Vale, W., 1985. Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. Science 230: 461-463.
106. Preston, R.L., Bartle, S.J., Kasser, T.R., Day, J.W., Veenhuizen, J.J. and Baile, C.A., 1995. Comparative effectiveness of somatotropin and anabolic steroids in feedlot steers. Journal of Animal Science 73: 1038-1047.
107. Randall, G.C., 1983. Changes in the concentrations of corticosteroids in the blood of fetal pigs and their dams during late gestation and labor. Biology of Reproduction 29: 1077-1084.
108. Rettori, V., Milenkovic, L., Riedel, M. and McCann, S.M., 1990. Physiological role of neuropeptide Y (NPY) in control of anterior pituitary hormone release in the rat. Endocrinology Experiments 24: 37-45.
109. Riley, J.E., 1989. Recent trends in pig production: the importance of intake. In: Forbes, J.M., Varley, M.A. and Lawrence, T.L.J. (eds.) The Voluntary Intake of Pigs. Occasional Publication of the British Society of Animal Production, pp 1-5.
110. Rossi, M., Kim, M.S., Morgan, D.G., Small, C.J., Edwards, C.M., Sunter, D., Abusnana, S., Goldstone, A.P., Russell, S.H., Stanley, S.A., Smith, D.M., Yagaloff, K., Ghatei, M.A. and Bloom, S.R., 1998. A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology 139: 4428-4431.
111. Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R.M., Tanaka, H., Williams, S.C., Richarson, J.A., Kozlowski, G.P., Wilson, S., Arch, J.R., Buckingham, R.E., Haynes, A.C., Carr, S.A., Annan, R.S., McNulty, D.E., Liu, W.S., Terrett, J.A., Elshourbagy, N.A., Bergsma, D.J. and Yanagisawa, M., 1998. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92: 1.
112. Salfen, B.E., Carroll, J.A. and Keisler, D.H., 2003. Endocrine responses to short-term feed deprivation in weanling pigs. Jounral of Endocrinology. 178: 541-551.
113. Salfen, B.E., Carroll, J.A., Keisler, D.H. and Strauch, T.A., 2004. Effects of exogenous ghrelin on feed intake, weight gain, behavior, and endocrine responses in weanling pigs. Journal of Animal Science 82: 1957-1966.
114. Sangild, P.T., Foltmann, B. and Cranwell, P.D., 1991. Development of gastric proteases in fetal pigs and pigs from birth to thirty six days of age. The effect of adrenocorticotropin (ACTH). Journal of Developmental Physiology 16: 229-238.
115. Sangild, P.T., Sjostrom, H., Noren, O., Fowden, A.L. and Silver, M., 1995. The prenatal development and glucocorticoid control of brush-border hydrolases in the pig small intestine. Pediatric Research 37: 207-212.
116. Sangild, P.T., Westrom, B.R., Fowden, A.L. and Silver, M., 1994. Developmental regulation of the porcine exocrine pancreas by glucocorticoids. J. Pediatr. Gastroenterol. Nutr. 19: 204-212.
117. Sartin, J.L., Dyer, C., Matteri, R., Buxton, D., Buonomo, F., Shores, M., Baker, J., Osborne, J.A., Braden, T. and Steele, B., 2001. Effect of intracerebroventricular orexin-B on food intake in sheep. Journal of Animal Science 79: 1573-1577.
118. Sartin, J.L., Marks, D.L., McMahon, C.D., Daniel, J.A., Levasseur, P., Wagner, C.G., Whitlock, B.K. and Steele, B.P., 2008. Central role of the melanocortin-4 receptors in appetite regulation after endotoxin. Journal of Animal Science 86: 2557-2567.
119. Scarlett, J.M., Zhu, X., Enriori, P.J., Bowe, D.D., Batra, A.K., Levasseur, P.R., Grant, W.F., Meguid, M.M., Cowley, M.A. and Marks, D.L., 2008. Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation. Endocrinology 149: 4837-4845.
120. Schoknecht, P.A., Ebner, S., Skottner, A., Burrin, D.G., Davis, T.A., Ellis, K. and Pond, W.G., 1997. Exogenous insulin-like growth factor-I increases weight gain in intrauterine growth-retarded neonatal pigs. Pediatric Research 42: 201-207.
121. Schwarz, F.J., Schams, D., Ropke, R., Kirchgessner, M., Kogel, J. and Matzke, P., 1993. Effects of somatotropin treatment on growth performance, carcass traits, and the endocrine system in finishing beef heifers. Journal of Animal Science 71: 2721-2731.
122. Scrimgeour, K., Gresham, M.J., Giles, L.R., Thomson, P.C., Wynn, P.C. and Newman, R.E., 2008. Ghrelin secretion is more closely aligned to energy balance than with feeding behaviour in the grower pig. Jounral of Endocrinology. 198: 135-145.
123. Seaman-Bridges, J.S., Carroll, J.A., Safranski, T.J. and Berg, E.P., 2003. Short-and long-term influence of perinatal dexamethasone treatment on swine growth. Domestic Animal Endocrinology 24: 193-208.
124. Seckl, J.R., Nyirenda, M.J., Walker, B.R. and Chapman, K.E., 1999. Glucocorticoids and fetal programming. Biochemical Society Transactions 27: 74-78.
125. Shintani, M., Ogawa, Y., Ebihara, K., Aizawa-Abe, M., Miyanaga, F., Takaya, K., Hayashi, T., Inoue, G., Hosoda, K., Kojima, M., Kangawa, K. and Nakao, K., 2001. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 50: 227-232.
126. Shutter, J.R., Graham, M., Kinsey, A.C., Scully, S., Luthy, R. and Stark, K.L., 1997. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes and Development 11: 593-602.
127. Solano, J.M. and Jacobson, L., 1999. Glucocorticoids reverse leptin effects on food intake and body fat in mice without increasing NPY mRNA. Am. J. Physiol 277: E708-E716.
128. Spina, M., Merlo-Pich, E., Chan, R.K., Basso, A.M., Rivier, J., Vale, W. and Koob, G.F., 1996. Appetitesuppressing effects of urocortin, a CRF-related neuropeptide. Science 273: 1561-1564.
129. Spurlock, M.E., Frank, G.R., Cornelius, S.G., Ji, S., Willis, G.M. and Bidwell, C.A. 1998a. Obese gene expression in porcine adipose tissue is reduced by food deprivation but not by maintenance or submaintenance intake. Journal of Nutrition 128: 677-682.
130. Spurlock, M.E., Ranalletta, M.A., Cornelius, S.G., Frank, G.R., Willis, G.M., Ji, S., Grant, A.L. and Bidwell, C.A. 1998b. Leptin expression in porcine adipose tissue is not increased by endotoxin but is reduced by growth hormone. J. Interferon Cytokine Res. 18: 1051-1058.
131. Straus, D.S., 1994. Nutritional regulation of hormones and growth factors that control mammalian growth. FASEB Journal 8: 6-12.
132. Takaya, K., Ariyasu, H., Kanamoto, N., Iwakura, H., Yoshimoto, A., Harada, M., Mori, K., Komatsu, Y., Usui, T., Shimatsu, A., Ogawa, Y., Hosoda, K., Akamizu, T., Kojima, M., Kangawa, K. and Nakao, K., 2000. Ghrelin strongly stimulates growth hormone release in humans. Journal of Clinical Endocrinololgy and Metabolism 85: 4908-4911.
133. Tamura, H., Kamegai, J., Sugihara, H., Kineman, R.D., Frohman, L.A. and Wakabayashi, I., 2000. Glucocorticoids regulate pituitary growth hormone secretagogue receptor gene expression. Journal of Neuroendocrinology. 12: 481-485.
134. Tartaglia, L.A., 1997. The leptin receptor. Journal of Biological Chemistry 272: 6093-6096.
135. Tartaglia, L.A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G.J., Campfield, L.A., Clark, F.T., Deeds, J., Muir, C., Sanker, S. Moriarty, A., Moore, K.J., Smutko, J.S., Mays, G.G., Wool, E.A., Monroe, C.A. and Tepper, R.I., 1995. Identification and expression cloning of a leptin receptor, OB-R. Cell 83: 1263-1271.
136. Tatemoto, K., 1982. Neuropeptide Y: complete amino acid sequence of the brain peptide. Proceedings of the National Acadamy of Science of the USA 79: 5485-5489.
137. Thomas, M.G., Gazal, O.S., Williams, G.L., Stanko, R.L. and Keisler, D.H., 1999. Injection of neuropeptide Y into the third cerebroventricle differentially influences pituitary secretion of luteinizing hormone and growth hormone in ovariectomized cows. Domestic Animal Endocrinology 16: 159-169.
138. Toshinai, K., Mondal, M.S., Nakazato, M., Date, Y., Murakami, N., Kojima, M., Kangawa, K. and Matsukura, S., 2001. Upregulation of Ghrelin Expression in the Stomach upon Fasting, Insulin-Induced Hypoglycemia, and Leptin Administration. Biochemical and Biophysical Research Communications 281: 1220-1225.
139. Touchette, K.J., Allee, G.L. and Newcomb, M.D., 1998. The effect of removing spray-dried plasma from the diet of nursery pigs on subsequent feed intake and weight gain. Journal of Animal Science 76 (Suppl. 1): 180.
140. Tritos, N.A., Elmquist, J.K., Mastaitis, J.W., Flier, J.S. and Maratos-Flier, E., 1998. Characterization of expression of hypothalamic appetite-regulating peptides in obese hyperleptinemic brown adipose tissue-deficient (uncoupling protein-promoter-driven diphtheria toxin A) mice. Endocrinology 139: 4634-4641.
141. Tschop, M., Smiley, D.L. and Heiman, M.L., 2000. Ghrelin induces adiposity in rodents. Nature 407: 908-913.
142. Underwood, W.J., 1995. Somatotropin use in farm animals. In: Proceedings of the 13th ACVM Forum. Lake Buena Vista, FL., USA.
143. Vaughan, J., Donaldson, C., Bittencourt, J., Perrin, M.H., Lewis, K., Sutton, S., Chan, R., Turnbull, A.V Lovejoy, D. and Rivier, C., 1995. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 378: 287-292.
144. Volante, M., Allia, E., Gugliotta, P., Funaro, A., Broglio, F., Deghenghi, R., Muccioli, G., Ghigo, E. and Papotti, M. 2002a. Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. Journal of Clinical Endocrinololgy and Metabolism 87: 1300-1308.
145. Volante, M., Fulcheri, E., Allia, E., Cerrato, M., Pucci, A. and Papotti, M. 2002b. Ghrelin expression in fetal, infant, and adult human lung. Journal of Histochemistry and Cytochemistry 50: 1013-1021.
146. Wagner, C.G., McMahon, D.D., Marks, D.L., Daniel, J.A., Steele, B. and Sartin, J.L., 2004. A role for agoutirelated protein in appetite regulation in a species with continuous nutrient delivery. Neuroendocrinology 80: 210-218.
147. Walton, P.E., Dunshea, F.R. and Ballard, F.J., 1995. In vivo actions of IGF analogues with poor affinities for IGFBPs: metabolic and growth effects in pigs of different ages and GH responsiveness. Progress in Growth Factor Research 6: 385-395.
148. Wehrenberg, W.B., Janowski, B.A., Piering, A.W., Culler, F. and Jones, K.L., 1990. Glucocorticoids: potent inhibitors and stimulators of growth hormone secretion. Endocrinology 126: 3200-3203.
149. Weigent, D.A., Baxter, J.B., Wear, W.E., Smith, L.R., Bost, K.L. and Blalock, J.E., 1988. Production of immunoreactive growth hormone by mononuclear leukocytes. FASEB Journal 2: 2812-2818.
150. Weigent, D.A. and Blalock, J.E., 1990. Immunoreactive growth hormone-releasing hormone in rat leukocytes. Journal of Neuroimmunology 29: 1-13.
151. Weiler, H.A., Wang, Z. and Atkinson, S.A., 1997. Whole body lean mass is altered by dexamethasone treatment through reductions in protein and energy utilization in piglets. Biology of the Neonate 71: 53-59.
152. Weisinger, R.S., Blair-West, J.R., Burns, P., Denton, D.A., McKinley, M.J., Purcell, B., Vale, W., Rivier, J. and Sunagawa, K., 2000. The inhibitory effect of hormones associated with stress on Na appetite of sheep. Proceedings of the National Academy of Sciences of the USA 97: 2922-2927.
153. Weller, P.A., Dauncey, M.J., Bates, P.C., Brameld, J.M., Buttery, P.J. and Gilmour, R.S., 1994. Regulation of porcine insulin-like growth factor I and growth hormone receptor mRNA expression by energy status. American Journal of Physiology 266: E776-E785.
154. Wester, T.J., Davis, T.A., Fiorotto, M.L. and Burrin, D.G., 1998. Exogenous growth hormone stimulates somatotropic axis function and growth in neonatal pigs. American Journal of Physiology 274: E29-E37.
155. Whitley, N.C., Barb, C.R., Kraeling, R.R., Barrett, J.B., Rampacek, G.B., Carroll, J.A. and Keisler, D.H., 2000. Feed intake and serum GH, LH and cortisol in gilts after intracerebroventricular or intravenous injection of urocortin. Domestic Animal Endocrinology 19: 209-221.
156. Wren, A.M., Seal, L.J., Cohen, M.A., Brynes, A.E., Frost, G.S., Murphy, K.G., Dhillo, W.S., Ghatei, M.A. and Bloom, S.R. 2001a. Ghrelin enhances appetite and increases food intake in humans. Journal of Clinical Endocrinololgy and Metabolism 86: 5992.
157. Wren, A.M., Small, C.J., Abbott, C.R., Dhillo, W.S., Seal, L.J., Cohen, M.A., Batterham, R.L., Taheri, S., Stanley, S.A., Ghatei, M.A. and Bloom, S.R. 2001b. Ghrelin causes hyperphagia and obesity in rats. Diabetes 50: 2540-2547.
158. Wright, K.J., Balaji, R., Hill, C.M., Dritz, S.S., Knoppel, E.L. and Minton, J.E., 2000. Integrated adrenal, somatotropic, and immune responses of growing pigs to treatment with lipopolysaccharide. Journal of Animal Science 78: 1892-1899.
159. Xiang, L., Murai, A. and Muramatsu, T., 2004. The effects of agouti-related protein gene transfer in vivo by electroporation in mice. Neuroscience Letters 370: 108-113.
160. Yen, X., Morrison, C. and Ramsay, T.G., Porcine leptin sequence and expression in lean and obese pigs. FASEB Journal 11, A415. 1997.
161. Youngstrom, T.G. and Bartness, T.J., 1995. Catecholaminergic innervation of white adipose tissue in Siberian hamsters. American Journal of Physiology 268: R744-R751.
162. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. and Friedman, J.M., 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432.