LC-MS/MS and GC-MS/MS measurement of plasma and urine di-paracetamol and 3-nitro-paracetamol: Proof-of-concept studies on a novel human model of oxidative stress based on oral paracetamol administration

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 959, Issue , 2014, Pages 71-81

  Trettin, Arne ^a   Modun, Darko ^b   Madunic, Sanja ^c   Vukovic, Jonatan ^c   Radman, Maja ^c   Batkai, Sandor ^a   Thum, Thomas ^a   Jordan, Jens ^a   Tsikas, Dimitrios ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF SPLIT   (Croatia)

^c UNIVERSITY HOSPITAL SPLIT   (Croatia)

Author keywords

Clinical trial; Dimerization; Human model; Nitration; Oxidative stress; Tandem mass spectrometry

Indexed keywords

AMINO ACIDS; BIOMARKERS; BIOMOLECULES; BODY FLUIDS; DIMERIZATION; DRUG DOSAGE; ISOTOPES; MAMMALS; MASS SPECTROMETRY; METABOLITES; NITRATION; OXIDATIVE STRESS; PLASMAS; SOLVENT EXTRACTION;

BIOLOGICAL SAMPLES; CLINICAL TRIAL; ELECTROPHILIC SPECIES; HUMAN MODEL; ORAL ADMINISTRATION; PARACETAMOL TABLETS; QUANTITATIVE DETERMINATIONS; TANDEM MASS SPECTROMETRY;

DRUG PRODUCTS;

3 NITRO PARACETAMOL; ACETIC ACID ETHYL ESTER; BENZYL DERIVATIVE; BROMINE DERIVATIVE; CREATININE; DIPARACETAMOL; HUMAN SERUM ALBUMIN; LUPOCET; PARACETAMOL; PENTAFLUOROBENZYL BROMIDE; PLACEBO; STABLE ISOTOPE; UNCLASSIFIED DRUG; ANALGESIC AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DERIVATIZATION; DIMERIZATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG URINE LEVEL; ERYTHROCYTE; GAS CHROMATOGRAPHY; HUMAN; HYDROPHOBICITY; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MALE; MOUSE; NITRATION; NONHUMAN; NORMAL HUMAN; OXIDATIVE STRESS; PILOT STUDY; PRIORITY JOURNAL; PROTEIN BINDING; SOLVENT EXTRACTION; TABLET; TANDEM MASS SPECTROMETRY; URINALYSIS; ANIMAL; BLOOD; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; MASS FRAGMENTOGRAPHY; ORAL DRUG ADMINISTRATION; URINE; YOUNG ADULT;

ACETAMINOPHEN; ADMINISTRATION, ORAL; ADULT; ANALGESICS, NON-NARCOTIC; ANIMALS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; MOLECULAR STRUCTURE; OXIDATIVE STRESS; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 84899130224     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.03.031     Document Type: Article

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