Determination of paracetamol and tramadol hydrochloride in pharmaceutical mixture using HPLC and GC-MS

Journal of Chromatographic Science

Volumn 47, Issue 10, 2009, Pages 849-854

  Belal, Tarek ^a   Awad, Tamer ^b   Clark, C Randall ^b  

^a Alexandria University Faculty of Pharmacy   (Egypt)

^b AUBURN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 70450175083     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/47.10.849     Document Type: Article

References (29)

1. B. Hinz and K. Brune. Antipyretic Analgesics: Nonsteroidal Anti-inflammatory Drugs, Selective COX-2Inhibitors, Paracetamol andPyrazolinones. Handbook of Experimental Pharmacology. 177(Analgesia): 65-93 (2006).
2. A. Bertolini, A. Ferrari, A. Ottani, S. Guerzoni, R. Tacchi, and S. Leone. Paracetamol: New Vistas of an Old Drug. CNS Drug Reviews 12(3-4): 250-275 (2006).
3. S. Grond and A. Sablotzki. Clinical Pharmacology of Tramadol. Clin. Pharmacokinet. 43(13): 879-923 (2004).
4. The United States Pharmacopeia 30th edition, The National Formulary, 25th edition "The Official Compendia of Standards", United States Pharmacopeial Convention, Inc., Asian Edition,Washington, D.C. (2007).
5. The British Pharmacopoeia, Volumes II and III, Her Majesty's Stationery Office, London, UK (2007).
6. M. Espinosa Bosch, A.J. Ruiz Sánchez, F. Sánchez Rojas, and C. Bosch Ojeda. Determination of paracetamol: Historical evolution. J. Pharm. Biomed. Anal. 42: 291-321 (2006).
7. W.F. Kartinasari, T. Palupi, and G. Indrayanto. HPLC determination and validation of tramadol hydrochloride in capsules. J. Liq. Chromatogr. Relat. Technol. 27(4): 737-744 (2004).
8. M.R. Rouini, Y.H. Ardakani, F. Soltani, H.Y. Aboul-Enein, and A. Foroumadi. Development and validation of a rapid HPLC method for simultaneous determination of tramadol, and its two main metabolites in human plasma. J. Chromatogr. B 830(2): 207-211 (2006).
9. K.A. Hadidi, J.K. Almasad, T. Al-Nsour, and S. Abu-Ragheib.Determination of tramadol in hair using solid phase extraction and GC-MS. Forensic Sci. Int. 135: 129-136 (2003).
10. Y.F. Sha, S. Shen, and G.L. Duan. Rapid determination of tramadol in human plasma by headspace solid-phase microextraction and capillary gas chromatography- mass spectrometry. J. Pharm. Biomed. Anal. 37: 143-147 (2005).
11. J. Krzek and M. Starek.Quality assessment for tramadol in pharmaceutical preparations with thin layer chromatography and densitometry. Biomed. Chromatogr. 18(8): 589-599 (2004).
12. U.B. Soetebeer, M.O. Schierenberg, H. Schulz, G. Gruenefeld, P. Andresen, and G. Blaschke. Assay of tramadol in urine by capillary electrophoresis using laser-induced native fluorescence detection. J.Chromatogr.B 745(2): 271-278 (2000).
13. J.G. Li and H.X. Ju. Simultaneous determination of ethamsylate, tramadol and lidocaine in human urine by capillary electrophoresis with electrochemiluminescence detection. Electrophoresis 27(17): 3467-3474 (2006).
14. P. Norouzi, R. Dinarvand, M.R. Ganjali, and A.S.E. Meibodi. Application of Adsorptive Stripping Voltammetry for the Nano-Level Detection of Tramadol in Biological Fluids and Tablets Using Fast Fourier Transform Continuous Cyclic Voltammetry at an Au Microelectrode in a Flowing System. Anal. Lett. 40(11): 2252-2270 (2007).
15. E.M.P.J. Garrido, J.M.P.J. Garrido, F. Borges, and C. Delerue-Matos. Development of electrochemical methods for determination of tramadol-analytical application to pharmaceutical dosage forms. J.Pharm.Biomed.Anal 32(4-5): 975-981 (2003).
16. H. Hopkala, G. Misztal, and A. Wieczorek. Tramadol selective PVC membrane electrodes and their analytical application.Die Pharmazie 53 (12):869-871(1998).
17. H.E. Abdellatef, M.M. El-Henawee, H.M. El-Sayed, and M.M. Ayad. Spectrophotometric and spectrofluorimetric methods for analysis of tramadol, acebutolol and dothiepin in pharmaceutical preparations. Spectrochim. Acta A 65(5): 1087-1092 (2006).
18. H.E. Abdellatef. Kinetic spectrophotometric determination of tramadol hydrochloride in pharmaceutical formulation. J. Pharm. Biomed. Anal. 29(5): 835-842 (2002).
19. T. Zhu, L. Ding, X. Guo, L. Yang, and A. Wen. Simultaneous Determination of Tramadol and Acetaminophen in Human Plasma by LC-ESI-MS. Chromatographia 66: 171-178 (2007).
20. Z. Tan, D. Ouyang, G. Zhou, L. Wang, Z. Li, D. Wang, G. Chen, S. Huang, Y. Liu, D. Hu, and H. Zhou. Determination of tramadol and paracetamol in human plasma by liquid chromatography ion trap mass spectrum. Yaowu Fenxi Zazhi 25(7): 795-798 (2005).
21. K.K. Srinivasan, J. Alex, A.A. Shirwaikar, S. Jacob, M.R. Sunil Kumar, and S.L. Prabu. Simultaneous derivative spectrophotometric estimation of aceclofenac and tramadol with paracetamol in combination solid dosage forms. Indian J. Pharm. Sci. 69(4): 540-545 (2007).
22. Y. Li, X. Wan, G. Wang, and J. Cui. Simultaneous determination of tramadol hydrochloride and paracetamol in their compound sustained release tablets by principal component regression spectrophotometry. Zhongguo Yaoxue Zazhi (Beijing, China) 41(20): 1594-1595 (2006).
23. X. Liu, J. Shi, Y. Liu, and Z. He. Simultaneous determination of contents of tramadol hydrochloride and paracetamol in their compound tablets by HPLC. Shenyang Yaoke Daxue Xuebao 21(2): 111-113 (2004).
24. L. Hong and J. Li. Determination of compound tramadol hydrochloride tablets and its related substances by HPLC. Zhongguo Yiyao Gongye Zazhi 36(5): 293-95 (2005).
25. D. Peng, K. Huang, Y. Liu, and M. Li. Simultaneous determination of two constituents in compound tramadol tablets by HPLC. Zhongguo Xinyao Zazhi 15(2): 120-122 (2006).
26. D.J. Speed, S.J. Dickson, E.R. Cairns, and N.D. Kim. Analysis of paracetamol using solid-phase extraction, deuterated internal standards, and gas chromatography-mass spectrometry. J. Anal. Toxicol. 25(3): 198-202 (2001).
27. F.W. McLafferty, and F. Turecek. Interpretation of Mass Spectra, Fourth edition University Science Books, Sausalito, CA, (1993).
28. P. Armitage, and G. Berry. Statistical Methods in Medical Research, Third Edition, Blackwell, Oxford, pp. 283-285 (1994).
29. J.N. Miller, and J.C. Miller. Statistics and Chemometrics for Analytical Chemistry, Fourth Edition, p. 57-64,77,78 (2000).