Discovery of substituted benzamides as follicle stimulating hormone receptor allosteric modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 9, 2014, Pages 2168-2172

  Yu, Henry N ^a,b   Richardson, Thomas E ^c   Nataraja, Selva ^b   Fischer, David J ^a   Sriraman, Venkataraman ^a   Jiang, Xuliang ^a   Bharathi, Pandi ^c   Foglesong, Robert J ^c   Haxell, Thomas F N ^c   Heasley, Brian H ^c   Jenks, Mathew ^c   Li, Jane ^a   Dugas, Melanie S ^a   Collis, Regina ^a   Tian, Hui ^a   Palmer, Stephen ^b   Goutopoulos, Andreas ^a  

^a EMD Serono Research Institute Inc   (United States)

^b TocopheRx   (United States)

^c Scynexis Inc   (United States)

Author keywords

Agonist; Antagonist; Glycoprotein hormone; Gonadotropin; GPCR; Infertility; Ovary; PAM; Reproductive

Indexed keywords

AMIDE; BENZAMIDE DERIVATIVE; CYCLOPROPANE DERIVATIVE; FOLLITROPIN RECEPTOR; FURAN DERIVATIVE; LUTEINIZING HORMONE RECEPTOR; METHYL GROUP; PIPERAZINE DERIVATIVE; PIPERIDINE; PYRIDINE DERIVATIVE; SULFONAMIDE; THYROTROPIN RECEPTOR; FERTILITY PROMOTING AGENT; FOLLICLE STIMULATING HORMONE RECEPTOR ALLOSTERIC MODULATOR; UNCLASSIFIED DRUG; FOLLITROPIN;

ANIMAL CELL; ARTICLE; CELL ASSAY; DRUG CLEARANCE; DRUG DEVELOPMENT; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GRANULOSA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OVARY HYPERSTIMULATION; PHARMACOKINETICS; RAT; STRUCTURE ACTIVITY RELATION; ALLOSTERISM; ANIMAL EXPERIMENT; HALF LIFE TIME; SUBSTITUTION REACTION; VOLUME OF DISTRIBUTION; AGONISTS; ANIMAL; CELL CULTURE; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; METABOLISM;

RATTUS;

ALLOSTERIC REGULATION; ANIMALS; BENZAMIDES; CELLS, CULTURED; CHO CELLS; CRICETULUS; FEMALE; FOLLICLE STIMULATING HORMONE; GRANULOSA CELLS; HUMANS; RATS;

EID: 84899081651     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.018     Document Type: Article

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