A negative allosteric modulator demonstrates biased antagonism of the follicle stimulating hormone receptor

Molecular and Cellular Endocrinology

Volumn 333, Issue 2, 2011, Pages 143-150

  Dias, James A ^a,b   Bonnet, Béatrice ^c   Weaver, Barbara A ^a   Watts, Julie ^a   Kluetzman, Kerri ^a,b   Thomas, Richard M ^a   Poli, Sonia ^c   Mutel, Vincent ^c   Campo, Brice ^c  

^a WADSWORTH CENTER   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c ADDEX PHARMACEUTICALS   (Switzerland)

Author keywords

Follicle stimulating hormone; Receptor; Small molecule

Indexed keywords

ADX 61623; ESTRADIOL; FOLLITROPIN DERIVATIVE; PROGESTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GRANULOSA CELL; HORMONE RESPONSE; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; IC 50; NONHUMAN; OVARY FOLLICLE DEVELOPMENT; PHARMACOLOGICAL BLOCKING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ALLOSTERIC REGULATION; ANIMALS; BENZAMIDES; CELL LINE; FEMALE; FOLLICLE STIMULATING HORMONE; GRANULOSA CELLS; HEK293 CELLS; HUMANS; IODINE RADIOISOTOPES; OOCYTES; RATS; RECEPTORS, FSH; RECOMBINATION, GENETIC;

EID: 79651470154     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2010.12.023     Document Type: Article

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