Investigation of a thiazolidinone derivative as an allosteric modulator of follicle stimulating hormone receptor: Evidence for its ability to support follicular development and ovulation

Biochemical Pharmacology

Volumn 89, Issue 2, 2014, Pages 266-275

  Sriraman, Venkataraman ^a   Denis, Deborah ^a   De Matos, Daniel ^a   Yu, Henry ^a,b   Palmer, Stephen ^b   Nataraja, Selva ^b  

^a EMD Serono Research Institute   (United States)

^b TocopheRx   (United States)

Author keywords

Follicular development; FSH receptor; FSH signalling; FSHR agonist; Glycoprotein hormone receptors; Ovulation

Indexed keywords

CYCLIC AMP; ESTRADIOL; FOLLITROPIN; FOLLITROPIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; THIAZOLE DERIVATIVE;

ALLOSTERISM; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG MEGADOSE; DRUG SAFETY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ESTROGEN SYNTHESIS; FEMALE; GENOTOXICITY; GRANULOSA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; OOCYTE; OVARY FOLLICLE; OVARY FOLLICLE DEVELOPMENT; OVARY FOLLICLE MATURATION; OVULATION; PREANTRAL FOLLICLE; PRIMARY CELL CULTURE; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SUPEROVULATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

FOLLICULAR DEVELOPMENT; FSH RECEPTOR; FSH SIGNALLING; FSHR AGONIST; GLYCOPROTEIN HORMONE RECEPTORS; OVULATION;

ALLOSTERIC REGULATION; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; FEMALE; GRANULOSA CELLS; HUMANS; MICE; OVARIAN FOLLICLE; OVULATION; RATS; RECEPTORS, FSH; THIAZOLIDINES;

EID: 84899418690     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.02.023     Document Type: Article

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