Signaling of an allosteric, nanomolar potent, low molecular weight agonist for the follicle-stimulating hormone receptor

Biochemical Pharmacology

Volumn 85, Issue 8, 2013, Pages 1162-1170

  Van Koppen, Chris J ^a,b   Verbost, Pieter M ^a   Van De Lagemaat, Ruud ^a   Karstens, Willem Jan F ^a   Loozen, Huub J J ^a   Van Achterberg, Tanja A E ^a   Van Amstel, Monique G A ^a   Brands, Jolanda H G M ^a   Van Doornmalen, Els J P ^a   Wat, Jesse ^a   Mulder, Saskia J ^a   Raafs, Bianca C ^a   Verkaik, Saskia ^a   Hanssen, Rob G J M ^a   Timmers, C Marco ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ElexoPharm GmbH   (Germany)

Author keywords

Agonist; Allosterism; FSH receptor; Infertility; Ovary

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; DIHYDROPYRIDINE DERIVATIVE; ESTRADIOL; FERTILITY PROMOTING AGENT; FOLLICLE STIMULATING HORMONE RECEPTOR AGONIST; FOLLITROPIN; LUTEINIZING HORMONE RECEPTOR; ORG 2144440; PHOSPHOLIPASE C; RECOMBINANT FOLLITROPIN; THYROTROPIN RECEPTOR; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL MEMBRANE; CONTROLLED STUDY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG POTENCY; FEMALE; FOLLICULAR PHASE; GRANULOSA CELL; HUMAN; HUMAN CELL; INCUBATION TIME; INTERNALIZATION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; RAT; SIGNAL TRANSDUCTION; STEREOCHEMISTRY;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; DIHYDROPYRIDINES; FEMALE; FOLLICLE STIMULATING HORMONE; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; RATS; RECEPTORS, FSH; SIGNAL TRANSDUCTION; SULFONAMIDES; TYPE C PHOSPHOLIPASES;

EID: 84875212528     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.02.001     Document Type: Article

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