Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening

European Journal of Medicinal Chemistry

Volumn 79, Issue , 2014, Pages 399-412

  Sun, Hao Peng ^a   Jia, Jian Min ^a   Jiang, Fen ^a   Xu, Xiao Li ^a   Liu, Fang ^a   Guo, Xiao Ke ^a   Cherfaoui, Bahidja ^a   Huang, Hao Ze ^a   Pan, Yang ^a   You, Qi Dong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Design and synthesis; Hsp90 inhibitors; ROCS

Indexed keywords

(2 AMINO 7,8 DIHYDROPYRIDO[4,3 D]PYRIMIDIN 6(5H) YL)(5 CHLORO 2,4 DIHYDROXYPHEN)METHANONE; (2 METHYL 7,8 DIHYDROPYRIDO[4,3 D]PYRIMIDIN 6(5H) YL)(5 CHLORO 2,4 DIHYDROXYPHENYL)METHANONE; (2,4 DIHYDROXYPHENYL)(2 (4 (PYRIMIDIN 2 YL)PIPERAZIN 1 YL) 7,8 DIHYDROPYRIDO[4,3 D]PYRIMIDIN 6(5H) YL)METHANONE; (2,4 DIMETHOXYPHENYL)(2 (4 (PYRIMIDIN 2 YL)PIPERAZIN 1 YL) 7,8 DIHYDROPYRIDO[4,3 D]PYRIMIDIN 6(5H) YL)METHANONE; (2,5 DIMETHOXYPHENYL)(2 (4 (PYRIMIDIN 2 YL)PIPERAZIN 1 YL) 7,8 DIHYDROPYRIDO[4,3 D]PYRIMIDIN 6(5H) YL)METHANONE; (4 CHLOROPHENYL)(2-(4 (PYRIMIDIN 2 YL)PIPERAZIN 1 YL) 7,8 DIHYDROPYRIDO[4,3 D]PYRIMIDIN 6(5H) YL)METHANONE; (4 FLUOROPHENYL)(2 (4 (PYRIMIDIN 2 YL)PIPERAZIN 1 YL) 7,8 DIHYDROPYRIDO[4,3 D]PYRIMIDIN 5(5H) YL)METHANONE; (5 CHLORO 2,4 DIHYDROXYPHENYL)(2 (4 (PYRIMIDIN 2 YL) PIPERAZIN 1 YL) 7,8 DIHYDRO[4,3 D]PYRIMIDIN 6(5H) YL)METHANONE; 2 (4 (PYRIMIDIN 2 YL)PIPERAZIN 1 YL) 5,6,7,8 TETRAHYDROPYRIDO[4,3 D]PYRIMIDINE; 6 BENZYL 2 (4 (PYRIMIDIN 2 YL)PIPERAZIN 1 YL) 5,6,7,8 TETRAHYDROPYRIDO[4,3 D]PYRIMIDINE; 6 BENZYL 2 CHLORO 5,6,7,8 TETRAHYDROPYRIDO[4,3 D]PYRIMIDINE; 6 BENZYL 2,4 DICHLORO 5,6,7,8 TETRAHYDROPYRIDO[4,3 D] PYRIMIDINE; 6 BENZYL 5,6,7,8 TETRAHYDROPYRIDO[4,3 D]PYRIMIDINE 2,4(1H,3H) DIONE; ALVESPIMYCIN; AT 13387; HEAT SHOCK PROTEIN 90 INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; HEAT SHOCK PROTEIN 90;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG CONFORMATION; DRUG DESIGN; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; PROCESS OPTIMIZATION; PROTEIN FOLDING; UBIQUITINATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HCT116 CELL LINE; HUMAN; MCF 7 CELL LINE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HCT116 CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899081467     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.061     Document Type: Article

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