Morphinans and isoquinolines: Acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 14, 2010, Pages 5071-5080

  Schuster, Daniela ^a   Spetea, Mariana ^a,b   Music, Melisa ^a   Rief, Silvia ^a   Fink, Monika ^a   Kirchmair, Johannes ^a   Schütz, Johannes ^a,b   Wolber, Gerhard ^a,c   Langer, Thierry ^a,c   Stuppner, Hermann ^a   Schmidhammer, Helmut ^a   Rollinger, Judith M ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b Life Science Center   (Austria)

^c Inte:Ligand Software Entwicklungs und Consulting GmbH   (Austria)

Author keywords

Acetylcholinesterase inhibition; Morphinans; Opioid receptor; Pharmacophore modeling

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; DELTA OPIATE RECEPTOR; DELTORPHIN; DONEPEZIL; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GALANTAMINE; ISOQUINOLINE DERIVATIVE; KAPPA OPIATE RECEPTOR; MORPHINAN DERIVATIVE; MU OPIATE RECEPTOR; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NATURAL PRODUCT; OPIATE RECEPTOR; RIVASTIGMINE; TACRINE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENZYME INHIBITION; IN VITRO STUDY; LIGAND BINDING; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; VALIDATION STUDY; VIRTUAL REALITY;

ACETYLCHOLINESTERASE; ANIMALS; CHOLINESTERASE INHIBITORS; GUINEA PIGS; ISOQUINOLINES; MODELS, MOLECULAR; MORPHINANS; RATS; RECEPTORS, OPIOID;

EID: 77955339023     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.05.071     Document Type: Article

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