Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Kaczocha, Martin ^a   Rebecchi, Mario J ^a   Ralph, Brian P ^b   Teng, Yu Han Gary ^b   Berger, William T ^b   Galbavy, William ^a   Elmes, Matthew W ^b   Glaser, Sherrye T ^c   Wang, Liqun ^b   Rizzo, Robert C ^d   Deutsch, Dale G ^b   Ojima, Iwao ^b  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c KINGSBOROUGH COMMUNITY COLLEGE   (United States)

^d Stony Brook University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2,4 DIPHENYLCYCLOBUTANE 1,3 DICARBOXYLIC ACID DI 1 NAPHTHYL AMIDE; ALPHA 2,4 DIPHENYLCYCLOBUTANE 1,3 DICARBOXYLIC ACID MONO 1 NAPHTHYL AMIDE; ALPHA 2,4 DIPHENYLCYCLOBUTANE 1,3 DICARBOXYLIC ACID MONO 1 NAPHTHYL ESTER; ALPHA 2,4 DIPHENYLCYCLOBUTANE 1,3 DICARBOXYLIC ACID MONO 2 NAPHTHYL ESTER; ANANDAMIDE; CANNABINOID 1 RECEPTOR; FATTY ACID BINDING PROTEIN; FATTY ACID BINDING PROTEIN 3; FATTY ACID BINDING PROTEIN 5; FATTY ACID BINDING PROTEIN 7; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; AMIDE; ANALGESIC AGENT; ARACHIDONIC ACID DERIVATIVE; ENDOCANNABINOID; PROTEIN BINDING;

ANALGESIA; ANANDAMIDE BRAIN LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BINDING AFFINITY; BRAIN LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; IN VIVO STUDY; INFLAMMATORY PAIN; INHIBITION KINETICS; MALE; MOUSE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PROTEIN INHIBITION; RAT; VISCERAL PAIN; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; HYPERALGESIA; METABOLISM; MOLECULAR DOCKING; NEURALGIA;

ANALGESIA; ANALGESICS; ANIMALS; ARACHIDONIC ACIDS; BRAIN; DISEASE MODELS, ANIMAL; ENDOCANNABINOIDS; FATTY ACID-BINDING PROTEINS; HYPERALGESIA; MALE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR DOCKING SIMULATION; NEURALGIA; POLYUNSATURATED ALKAMIDES; PPAR ALPHA; PROTEIN BINDING; RATS; RECEPTOR, CANNABINOID, CB1;

EID: 84899067762     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094200     Document Type: Article

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