Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP)

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 12, 2007, Pages 3511-3515

  Sulsky, Richard ^a   Magnin, David R ^a   Huang, Yanting ^a   Simpkins, Ligaya ^a   Taunk, Prakash ^a   Patel, Manorama ^a   Zhu, Yeheng ^a   Stouch, Terry R ^a   Bassolino Klimas, Donna ^a   Parker, Rex ^a   Harrity, Thomas ^a   Stoffel, Robert ^a   Taylor, David S ^a   Lavoie, Thomas B ^a   Kish, Kevin ^a   Jacobson, Bruce L ^b   Sheriff, Steven ^a   Adam, Leonard P ^a   Ewing, William R ^a   Robl, Jeffrey A ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^b ST CLOUD STATE UNIVERSITY   (United States)

Author keywords

aFABP; aP2; Biphenyl azoles; Fatty acid binding protein; Radioligand assay

Indexed keywords

ADIPOCYTE FATTY ACID BINDING PROTEIN INHIBITOR; BIPHENYL DERIVATIVE; FATTY ACID BINDING PROTEIN; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; BINDING AFFINITY; BINDING KINETICS; DIABETES MELLITUS; DRUG BINDING; DRUG POTENCY; DRUG SELECTIVITY; EPIDERMIS; FATTY ACID SYNTHESIS; LIGAND BINDING; MOUSE; MUSCLE TISSUE; NANOANALYSIS; NONHUMAN; OBESITY; PROTEIN SYNTHESIS;

ADIPOCYTES; ANIMALS; ANTILIPEMIC AGENTS; AZOLES; BINDING SITES; BIPHENYL COMPOUNDS; DISEASE MODELS, ANIMAL; EPIDERMIS; FATTY ACID-BINDING PROTEINS; HYPOGLYCEMIC AGENTS; MICE; MODELS, CHEMICAL; RADIOLIGAND ASSAY;

EID: 34249727188     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.12.044     Document Type: Article

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