Rosiglitazone is a superior bronchodilator compared to chloroquine and β-adrenoceptor agonists in mouse lung slices

Respiratory Research

Volumn 15, Issue 1, 2014, Pages

  Donovan, Chantal ^a   Simoons, Mirjam ^a   Esposito, James ^a   Ni Cheong, Jean ^a   FitzPatrick, Meaghan ^a   Bourke, Jane E ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Chloroquine; Mouse lung slices; Rosiglitazone; Small airways; adrenoceptor agonists

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CAFFEINE; CHLOROQUINE; ISOPRENALINE; METHACHOLINE; ROSIGLITAZONE; RYANODINE; SALBUTAMOL; 2,4 THIAZOLIDINEDIONE DERIVATIVE; BRONCHODILATING AGENT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHOCONSTRICTION; CLINICAL ASSESSMENT; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DRUG EFFICACY; IMAGE ANALYSIS; LUNG SLICE; MALE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; TREATMENT RESPONSE; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECT; LUNG; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY;

ADRENERGIC BETA-AGONISTS; ANIMALS; BRONCHODILATOR AGENTS; CHLOROQUINE; LUNG; MALE; MICE; MICE, INBRED BALB C; ORGAN CULTURE TECHNIQUES; THIAZOLIDINEDIONES;

EID: 84899051139     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-15-29     Document Type: Article

References (42)

1. Barnes PJ, Woolcock AJ. Difficult asthma. Eur Respir J 1998, 12:1209-1218. 10.1183/09031936.98.12051209, 9864023.
2. Dockrell M, Partridge MR, Valovirta E. The limitations of severe asthma: the results of a European survey. Allergy 2007, 62:134-141.
3. Gerthoffer WT, Solway J, Camoretti-Mercado B. Emerging targets for novel therapy of asthma. Curr Opin Pharmacol 2013, 13:324-330. 10.1016/j.coph.2013.04.002, 23639507.
4. Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat Med 2010, 16:1299-1304. 10.1038/nm.2237, 3066567, 20972434.
5. Donovan C, Tan X, Bourke JE. PPARgamma ligands regulate noncontractile and contractile functions of airway smooth muscle: implications for asthma therapy. PPAR Res 2012, 2012:809164. 3431171, 22966222.
6. Bourke JE, Bai Y, Donovan C, Esposito JG, Tan X, Sanderson MJ. Novel small airway bronchodilator responses to rosiglitazone in mouse lung slices. Am J Respir Cell Mol Biol 2013, [Epub ahead of print].
7. Benayoun L, Letuve S, Druilhe A, Boczkowski J, Dombret MC, Mechighel P, Megret J, Leseche G, Aubier M, Pretolani M. Regulation of peroxisome proliferator-activated receptor gamma expression in human asthmatic airways: relationship with proliferation, apoptosis, and airway remodeling. Am J Respir Crit Care Med 2001, 164:1487-1494. 10.1164/ajrccm.164.8.2101070, 11704601.
8. An SS, Wang WC, Koziol-White CJ, Ahn K, Lee DY, Kurten RC, Panettieri RA, Liggett SB. TAS2R activation promotes airway smooth muscle relaxation despite beta (2)-adrenergic receptor tachyphylaxis. Am J Physiol Lung Cell Mol Physiol 2012, 303:L304-311. 10.1152/ajplung.00126.2012, 3423830, 22683571.
9. Tan X, Sanderson MJ. Bitter-taste compounds dilate airways by inhibiting airway smooth muscle calcium oscillations and calcium sensitivity. Br J Pharmacol 2014, 171:646-62. 10.1111/bph.12460, 24117140.
10. Orsmark-Pietras C, James A, Konradsen JR, Nordlund B, Soderhall C, Pulkkinen V, Pedroletti C, Daham K, Kupczyk M, Dahlen B, Orsmark-Pietras C, James A, Konradsen JR, Nordlund B, Söderhäll C, Pulkkinen V, Pedroletti C, Daham K, Kupczyk M, Dahlén B, Kere J, Dahlén SE, Hedlin G, Melén E. Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics. Eur Respir J 2013, 42:65-78. 10.1183/09031936.00077712, 23222870.
11. Hancox RJ, Aldridge RE, Cowan JO, Flannery EM, Herbison GP, McLachlan CR, Town GI, Taylor DR. Tolerance to beta-agonists during acute bronchoconstriction. Eur Respir J 1999, 14:283-287.
12. Sovani MP, Whale CI, Tattersfield AE. A benefit-risk assessment of inhaled long-acting beta2-agonists in the management of obstructive pulmonary disease. Drug Saf 2004, 27:689-715. 10.2165/00002018-200427100-00001, 15350154.
13. Persson CG. Small airway relaxation-a forgotten medical need. Pulm Pharmacol Ther 2008, 21:1-3. 10.1016/j.pupt.2006.10.017, 17169595.
14. Sturton G, Persson C, Barnes PJ. Small airways: an important but neglected target in the treatment of obstructive airway diseases. Trends Pharmacol Sci 2008, 29:340-345. 10.1016/j.tips.2008.04.003, 18514920.
15. Burgel PR. The role of small airways in obstructive airway diseases. Eur Respir Rev 2011, 20:23-33. 10.1183/09059180.00010410, 21357889.
16. Mechiche H, Naline E, Candenas L, Pinto FM, Birembault P, Advenier C, Devillier P. Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites. Clin Exp Allergy 2003, 33:887-894. 10.1046/j.1365-2222.2003.01696.x, 12859443.
17. Finney MJ, Karlsson JA, Persson CG. Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation. Br J Pharmacol 1985, 85:29-36. 10.1111/j.1476-5381.1985.tb08827.x, 1916766, 2411319.
18. Cooper PR, Panettieri RA. Steroids completely reverse albuterol-induced beta (2)-adrenergic receptor tolerance in human small airways. J Allergy Clin Immunol 2008, 122:734-740. 10.1016/j.jaci.2008.07.040, 18774166.
19. Cooper P, Kurten R, Zhang J, Nicholls D, Dainty I, Panettieri R. Formoterol and salmeterol induce a similar degree of beta (2) -adrenoceptor tolerance in human small airways but via different mechanisms. Br J Pharmacol 2011, 163:521-532. 10.1111/j.1476-5381.2011.01257.x, 3101615, 21306583.
20. Donovan C, Royce SG, Esposito J, Tran J, Ibrahim ZA, Tang ML, Bailey S, Bourke JE. Differential effects of allergen challenge on large and small airway reactivity in mice. PloS One 2013, 8:e74101. 10.1371/journal.pone.0074101, 3765301, 24040180.
21. FitzPatrick M, Donovan C, Bourke JE. Prostaglandin E elicits greater bronchodilation than salbutamol in mouse intrapulmonary airways in lung slices. Pulm Pharmacol Ther 2013, [Epub ahead of print].
22. Bai Y, Sanderson MJ. Modulation of the Ca2+ sensitivity of airway smooth muscle cells in murine lung slices. Am J Physiol Lung Cell Mol Physiol 2006, 291:L208-221. 10.1152/ajplung.00494.2005, 16461427.
23. Miura M, Belvisi MG, Stretton CD, Yacoub MH, Barnes PJ. Role of potassium channels in bronchodilator responses in human airways. Am Rev Respir Dis 1992, 146:132-136. 10.1164/ajrccm/146.1.132, 1378252.
24. Barnes PJ. Pharmacology of airway smooth muscle. Am J Respir Crit Care Med 1998, 158:S123-132. 10.1164/ajrccm.158.supplement_2.13tac800, 9817735.
25. Henry PJ, D'Aprile A, Self G, Hong T, Mann TS. Inhibitors of prostaglandin transport and metabolism augment protease-activated receptor-2-mediated increases in prostaglandin E2 levels and smooth muscle relaxation in mouse isolated trachea. J Pharmacol Exp Ther 2005, 314:995-1001. 10.1124/jpet.105.086124, 15937152.
26. Belvisi MG, Dale N, Birrell MA, Canning BJ. Bronchodilator activity of bitter tastants in human tissue. Nat Med 2011, 17:776-778. 10.1038/nm0711-776a, 21738151.
27. Morice AH, Bennett RT, Chaudhry MA, Cowen ME, Griffin SC, Loubani M. Effect of bitter tastants on human bronchi. Nat Med 2011, 17:775. 10.1038/nm0711-775, 21738149.
28. Lemoine H, Overlack C. Highly potent beta-2 sympathomimetics convert to less potent partial agonists as relaxants of guinea pig tracheae maximally contracted by carbachol. Comparison of relaxation with receptor binding and adenylate cyclase stimulation. J Pharmacol Exp Ther 1992, 261:258-270.
29. Pulkkinen V, Manson ML, Safholm J, Adner M, Dahlen SE. The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea. Am J Physiol Lung Cell Mol Physiol 2012, 303:L956-966. 10.1152/ajplung.00205.2012, 22962016.
30. Johnson M. The beta-adrenoceptor. Am J Respir Crit Care Med 1998, 158:S146-153. 10.1164/ajrccm.158.supplement_2.13tac110, 9817738.
31. Billington CK, Ojo OO, Penn RB, Ito S. cAMP regulation of airway smooth muscle function. Pulm Pharmacol Ther 2013, 26:112-120. 10.1016/j.pupt.2012.05.007, 3574867, 22634112.
32. Robinett KS, Deshpande DA, Malone MM, Liggett SB. Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors. Am J Respir Cell Mol Biol 2011, 45:1069-1074. 10.1165/rcmb.2011-0061OC, 3361362, 21642585.
33. Liggett SB. Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators. Expert Opin Ther Targets 2013, 17:721-731. 10.1517/14728222.2013.782395, 23577615.
34. Henry PJ, Goldie RG. Beta 1-adrenoceptors mediate smooth muscle relaxation in mouse isolated trachea. Br J Pharmacol 1990, 99:131-135. 10.1111/j.1476-5381.1990.tb14666.x, 1917490, 2158831.
35. Delmotte P, Sanderson MJ. Effects of albuterol isomers on the contraction and Ca2+ signaling of small airways in mouse lung slices. Am J Respir Cell Mol Biol 2008, 38:524-531. 10.1165/rcmb.2007-0214OC, 2335335, 18063837.
36. Zhang CH, Chen C, Lifshitz LM, Fogarty KE, Zhu MS, ZhuGe R. Activation of BK channels may not be required for bitter tastant-induced bronchodilation. Nat Med 2012, 18:648-650. author reply 650-641, 10.1038/nm.2733, 22561814.
37. Ong HL, Barritt GJ. Transient receptor potential and other ion channels as pharmaceutical targets in airway smooth muscle cells. Respirology 2004, 9:448-457. 10.1111/j.1440-1843.2004.00651.x, 15612955.
38. Zhang CH, Lifshitz LM, Uy KF, Ikebe M, Fogarty KE, ZhuGe R. The cellular and molecular basis of bitter tastant-induced bronchodilation. PLoS Biol 2013, 11:e1001501. 10.1371/journal.pbio.1001501, 3589262, 23472053.
39. Perez JF, Sanderson MJ. The frequency of calcium oscillations induced by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchioles. J Gen Physiol 2005, 125:535-553. 10.1085/jgp.200409216, 2234076, 15928401.
40. Faurschou P, Mikkelsen KL, Steffensen I, Franke B. The lack of bronchodilator effect and the short-term safety of cumulative single doses of an inhaled potassium channel opener (bimakalim) in adult patients with mild to moderate bronchial asthma. Pulm Pharmacol 1994, 7:293-297. 10.1006/pulp.1994.1034, 7626915.
41. Kidney JC, Fuller RW, Worsdell YM, Lavender EA, Chung KF, Barnes PJ. Effect of an oral potassium channel activator, BRL 38227, on airway function and responsiveness in asthmatic patients: comparison with oral salbutamol. Thorax 1993, 48:130-133. 10.1136/thx.48.2.130, 464287, 8493625.
42. Janssen LJ. Ionic mechanisms and Ca(2+) regulation in airway smooth muscle contraction: do the data contradict dogma?. Am J Physiol Lung Cell Mol Physiol 2002, 282:L1161-1178. 10.1152/ajpcell.00413.2001, 12003770.