Effects of albuterol isomers on the contraction and Ca2+ signaling of small airways in mouse lung slices

American Journal of Respiratory Cell and Molecular Biology

Volumn 38, Issue 5, 2008, Pages 524-531

  Delmotte, Philippe ^a   Sanderson, Michael J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

2 agonist; Ca2+ oscillations; Ca2+ sensitivity; Hyper reactivity; Relaxation

Indexed keywords

CALCIUM ION; METHACHOLINE; SALBUTAMOL; BRONCHODILATING AGENT;

ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFECT; LUNG SLICE; MOUSE; MUSCLE CONTRACTION; NONHUMAN; PHASE CONTRAST MICROSCOPY; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; ANIMAL; BAGG ALBINO MOUSE; BRONCHOSPASM; BRONCHUS; CHEMISTRY; COMPARATIVE STUDY; LUNG; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; STEREOISOMERISM;

ALBUTEROL; ANIMALS; BRONCHI; BRONCHOCONSTRICTION; BRONCHODILATOR AGENTS; CALCIUM SIGNALING; LUNG; MICE; MICE, INBRED BALB C; ORGAN CULTURE TECHNIQUES; STEREOISOMERISM;

EID: 42949120559     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2007-0214OC     Document Type: Article

References (26)

1. GINA. Global Strategy for Asthma Management and Prevention NIH Publication No 02-3659 Management Segment (Chapter 7): 2004. Available at www.ginasthma.org.; 2004.
2. Blake K. Review of guidelines and the literature in the treatment of acute bronchospasm in asthma. Pharmacotherapy 2006;26:148S-155S.
3. Nowak RM, Emerman CL, Schaefer K, Disantostefano RL, Vaickus L, Roach JM. Levalbuterol compared with racemic albuterol in the treatment of acute asthma: results of a pilot study. Am J Emerg Med 2004;22:29-36.
4. Nowak R. Single-isomer levalbuterol: a review of the acute data. Curr Allergy Asthma Rep 2003;3:172-178.
5. Berger WE. Levalbuterol: pharmacologic properties and use in the treatment of pediatric and adult asthma. Ann Allergy Asthma Immunol 2003;90:583-591; quiz 591-582, 659.
6. Scott VL, Frazee LA. Retrospective comparison of nebulized levalbuterol and albuterol for adverse events in patients with acute airflow obstruction. Am J Ther 2003;10:341-347.
7. Carl JC, Myers TR, Kirchner HL, Kercsmar CM. Comparison of racemic albuterol and levalbuterol for treatment of acute asthma. J Pediatr 2003;143:731-736.
8. Ahrens R, Weinberger M. Levalbuterol and racemic albuterol: are there therapeutic differences? J Allergy Clin Immunol 2001;108:681-684.
9. Lotvall J, Palmqvist M, Arvidsson P, Maloney A, Ventresca GP, Ward J. The therapeutic ratio of R-albuterol is comparable with that of RS-albuterol in asthmatic patients. J Allergy Clin Immunol 2001;108:726-731.
10. Barnes PJ. Treatment with (R)-albuterol has no advantage over racemic albuterol. Am J Respir Crit Care Med 2006;174:969-972. (discussion 972-964).
11. Agrawal DK, Ariyarathna K, Kelbe PW. (S)-Albuterol activates proconstrictory and pro-inflammatory pathways in human bronchial smooth muscle cells. J Allergy Clin Immunol 2004;113:503-510.
12. Zhang XY, Zhu FX, Olszewski MA, Robinson NE. Effects of enantiomers of beta 2-agonists on ACh release and smooth muscle contraction in the trachea. Am J Physiol 1998;274:L32-L38.
13. Johansson F, Rydberg I, Aberg G, Andersson RG. Effects of albuterol enantiomers on in vitro bronchial reactivity. Clin Rev Allergy Immunol 1996;14:57-64.
14. Mitra S, Ugur M, Ugur O, Goodman HM, McCullough JR, Yamaguchi H. (S)-Albuterol increases intracellular free calcium by muscarinic receptor activation and a phospholipase C-dependent mechanism in airway smooth muscle. Mol Pharmacol 1998;53:347-354.
15. Perez JF, Sanderson MJ. The frequency of calcium oscillations induced by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchioles. J Gen Physiol 2005;125:535-553.
16. Bai Y, Sanderson MJ. Airway smooth muscle relaxation results from a reduction in the frequency of Ca2+ oscillations induced by a cAMP-mediated inhibition of the IP3 receptor. Respir Res 2006;7:34.
17. Prakash YS, Kannan MS, Sieck GC. Regulation of intracellular calcium oscillations in porcine tracheal smooth muscle cells. Am J Physiol 1997;272:C966-C975.
18. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 2003;4:517-529.
19. Somlyo AP, Somlyo AV. Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 2003;83:1325-1358.
20. Oguma T, Kume H, Ito S, Takeda N, Honjo H, Kodama I, Shimokata K, Kamiya K. Involvement of reduced sensitivity to Ca in beta-adrenergic action on airway smooth muscle. Clin Exp Allergy 2006;36:183-191.
21. Bai Y, Sanderson MJ. Modulation of the Ca2+ sensitivity of airway smooth muscle cells in murine lung slices. Am J Physiol Lung Cell Mol Physiol 2006;291:L208-L221.
22. Sanderson MJ, Parker I. Video-rate confocal microscopy. Methods Enzymol 2003;360:447-481.
23. Sanderson MJ. Acquisition of multiple real-time images for laser scanning microscopy. Microscopy and Analysis 2004;18:17-23.
24. Sears MR, Lotvall J. Past, present and future-beta2-adrenoceptor agonists in asthma management. Respir Med 2005;99:152-170.
25. Baramki D, Koester J, Anderson AJ, Borish L. Modulation of T-cell function by (R)- and (S)-isomers of albuterol: anti-inflammatory influences of (R)-isomers are negated in the presence of the (S)-isomer. J Allergy Clin Immunol 2002;109:449-454.
26. Henderson WR Jr, Banerjee ER, Chi EY. Differential effects of (S)- and (R)-enantiomers of albuterol in a mouse asthma model. J Allergy Clin Immunol 2005;116:332-340.