The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 303, Issue 11, 2012, Pages

  Pulkkinen, Ville ^a,b   Manson, Martijn L ^a   Säfholm, Jesper ^a   Adner, Mikael ^a   Dahlén, Sven Erik ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Airway smooth muscle; Asthma; Bronchodilation; Prostaglandins

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ANTIGEN; BITTER TASTE SENSING TYPE 2 RECEPTOR; BRADYKININ; CARBACHOL; CHLOROQUINE; DENATONIUM BENZOATE; G PROTEIN COUPLED RECEPTOR; HISTAMINE; INDOMETACIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LEUKOTRIENE D4; MESSENGER RNA; NOSCAPINE; ONO 8130; OVALBUMIN; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; SQ 29648; THIAMINE; THROMBOXANE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRONCHODILATATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; GENE EXPRESSION; GUINEA PIG; MALE; MUSCLE EXCITATION; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; SMOOTH MUSCLE RELAXATION; TASTE BUD; TRACHEA; TRACHEA MUCOSA;

ALBUTEROL; ANIMALS; BRONCHODILATOR AGENTS; CARBACHOL; CHARYBDOTOXIN; CHLOROQUINE; CHOLINERGIC AGONISTS; GENE EXPRESSION; GUINEA PIGS; INDOLES; INDOMETHACIN; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; PEPTIDES; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, G-PROTEIN-COUPLED; RESPIRATORY MUCOSA; TRACHEA;

EID: 84870879028     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00205.2012     Document Type: Article

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