Eugenolol and glyceryl-isoeugenol suppress LPS-induced iNOS expression by down-regulating NF-κB and AP-1 through inhibition of MAPKs and Akt/IκBα signaling pathways in macrophages

International Journal of Immunopathology and Pharmacology

Volumn 24, Issue 2, 2011, Pages 345-356

  Yeh, J L ^a   Hsu, J H ^a,b   Hong, Y S ^a   Wu, J R ^a,b   Liang, J C ^c   Wu, B N ^a   Chen, I J ^a   Liou, Shu Fen ^d  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^d CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

Author keywords

Derivatives; Inflammation; Lipopolysaccharide; Mitogen activated protein kinases; Transcription factor

Indexed keywords

ANTIINFLAMMATORY AGENT; EUGENOL; GLYCERYL ISOEUGENOL; I KAPPA B; I KAPPA B ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; ISOEUGENOL; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PROTEIN KINASE B; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLYCEROL DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRITE; STRESS ACTIVATED PROTEIN KINASE; AUTACOID; CREB1 PROTEIN, MOUSE; DRUG DERIVATIVE; ENDOTOXIN; ENDOTOXIN, ESCHERICHIA COLI; GLYCEROL; GLYCERYL-ISOEUGENOL; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; NITRIC OXIDE; NOS2 PROTEIN, MOUSE; RELA PROTEIN, MOUSE; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATTENUATION; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; GENE TRANSLOCATION; INTRACELLULAR SIGNALING; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; CELL VIABILITY; GENE EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL LINE; CELL SURVIVAL; DOSE RESPONSE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL SURVIVAL; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENDOTOXINS; EUGENOL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCEROL; I-KAPPA B PROTEINS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80051777105     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463201102400208     Document Type: Article

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