Microbial transformation of isosteviol oxime and the inhibitory effects on NF-κB and AP-1 activation in LPS-stimulated macrophages

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 17, 2009, Pages 6348-6353

  Chang, Shwu Fen ^b   Chou, Bo Hon ^a   Yang, Li Ming ^a,c   Hsu, Feng Lin ^a   Lin, Wen Kuang ^a   Ho, Yi ^a   Lin, Shwu Jiuan ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b School of Medicine   (Taiwan)

^c NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

AP 1; Diterpenoid; Isosteviol oxime; Microbial transformation; NF B

Indexed keywords

4ALPHA CARBOXY 13ALPHA AMINO 13,16 SECO ENT 19 NORBEYERAN 16 OIC ACID 13,16 LACTAM; 4ALPHA CARBOXY 13ALPHA HYDROXY 13,16 SECO ENT 19 NORBEYERAN 16 OIC ACID 13,16 LACTONE; DEXAMETHASONE; ENT 1BETA HYDROXY 16 HYDROXYIMINOBEYERAN 19 OIC ACID; ENT 1BETA,7ALPHA DIHYDROXY 16 HYDROXYIMINOBEYERAN 19 OIC ACID; ENT 1BETA,7ALPHA DIHYDROXY 16 OXOBEYERAN 19 OIC ACID; ENT 7ALPHA HYDROXY 16 HYDROXYIMINOBEYERAN 19 OIC ACID; ENT 8BETA CYANOMETHYL 13 METHYL 12 PODOCARPEN 19 OIC ACID; ENT 8BETA CYANOMETHYL 13 METHYL 13 PODOCARPEN 19 OIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOSTEVIOL OXIME; LACTAM DERIVATIVE; LACTONE DERIVATIVE; LIPOPOLYSACCHARIDE; OXIME DERIVATIVE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ABSIDIA; ABSIDIA PSEUDOCYLINDROSPORA; ANIMAL CELL; ARTICLE; ASPERGILLUS NIGER; BIOTRANSFORMATION; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ISOLATION; DRUG POTENCY; DRUG SCREENING; MACROPHAGE; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DITERPENES, KAURANE; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MOLECULAR CONFORMATION; NF-KAPPA B; OXIMES; TRANSCRIPTION FACTOR AP-1;

ABSIDIA; ASPERGILLUS NIGER;

EID: 68649087855     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.07.029     Document Type: Article

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