Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-α

Biochemistry

Volumn 53, Issue 10, 2014, Pages 1697-1713

  Ziemba, Brian P ^a   Li, Jianing ^b   Landgraf, Kyle E ^a,c   Knight, Jefferson D ^a,d   Voth, Gregory A ^b   Falke, Joseph J ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c AvidBiotics Corporation   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CELL PROLIFERATION; CHEMICAL ACTIVATION; FLUORESCENCE MICROSCOPY; LIPID BILAYERS; MOLECULES; REFRACTIVE INDEX; SURFACE DIFFUSION;

MEMBRANE-BOUND ENZYMES; MEMBRANE-BOUND PROTEINS; PHOSPHATIDYLINOSITOL 4 ,5-BISPHOSPHATE; SINGLE-MOLECULE METHODS; SINGLE-MOLECULE STUDIES; SUPPORTED LIPID BILAYERS; TOTAL INTERNAL REFLECTION FLUORESCENCE MICROSCOPY; TWO DIMENSIONAL DIFFUSION;

ENZYMES;

CALCIUM ION; DIACYLGLYCEROL; PHORBOL ESTER; PHOSPHATIDYLSERINE; PROTEIN KINASE C ALPHA;

ARTICLE; BILAYER MEMBRANE; CELL MEMBRANE; CYTOPLASM; ENZYME ACTIVATION; FLUORESCENCE MICROSCOPY; LIPID BILAYER; MEMBRANE BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; TOTAL INTERNAL REFLECTION FLUORESCENCE MICROSCOPY;

CELL MEMBRANE; ENZYME ACTIVATION; HUMANS; LIPID BILAYERS; PHOSPHATIDYLSERINES; PROTEIN BINDING; PROTEIN KINASE C-ALPHA; PROTEIN STRUCTURE, TERTIARY;

EID: 84899011868     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi4016082     Document Type: Article

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