Spatiotemporal dynamics of lipid signaling: protein kinase C as a paradigm

IUBMB Life

Volumn 60, Issue 12, 2008, Pages 782-789

  Gallegos, Lisa L ^a   Newton, Alexandra C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Diacylglycerol; Lipid second messenger; Protein kinase C

Indexed keywords

CALCIUM; DIACYLGLYCEROL; ISOENZYME; ISOPROTEIN; LIPID; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE ASSOCIATED GUANYLATE CYCLASE KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOLIPASE C; PROTEIN INTERACTING WITH PROTEIN KINASE C; PROTEIN KINASE C; 1,2-DIACYLGLYCEROL; UNCLASSIFIED DRUG;

CELL; INTRACELLULAR MEMBRANE; MEMBRANE BINDING; REVIEW; SECOND MESSENGER; ANIMAL; CELL MEMBRANE; ENZYMOLOGY; HUMAN; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL MEMBRANE; DIGLYCERIDES; HUMANS; PROTEIN KINASE C; SECOND MESSENGER SYSTEMS;

EID: 58149169884     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.122     Document Type: Review

References (51)

1. Di Paolo, G. and De Camilli, P. (2006) Phosphoinositides in cell regulation and membrane dynamics. Nature 443, 651-657.
2. Carrasco, S. and Merida, I. (2004) Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes. Mol. Biol. Cell. 15, 2932-2942.
3. Dries, D. R., Gallegos, L. L., and Newton, A. C. (2007) A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production. J Biol Chem 282, 826-830.
4. Villani, M., Subathra, M., Im, Y. B., Choi, Y., Signorelli, P., Del Poeta, M., and Luberto, C. (2008) Sphingomyelin synthases regulate production of diacylglycerol at the golgi. Biochem. J. (in press) [Epub ahead of print.]
5. Yeung, T., Gilbert, G. E., Shi, J., Silvius, J., Kapus, A., and Grinstein, S. (2008) Membrane phosphatidylserine regulates surface charge and protein localization. Science 319, 210-213.
6. Hurley, J. H. and Misra, S. (2000) Signaling and subcellular targeting by membrane-binding domains. Annu. Rev. Biophys. Biomol. Struct. 29, 49-79.
7. Hurley, J. H. (2006) Membrane binding domains. Biochim. Biophys. Acta. 1761, 805-811.
8. Newton, A. C. (2003) Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem. J. 370, 361-371.
9. Inoue, M., Kishimoto, A., Takai, Y., and Nishizuka, Y. (1977) Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain. J. Biol. Chem. 252, 7610-7616.
10. Takai, Y., Kishimoto, A., Kikkawa, U., Mori, T., and Nishizuka, Y. (1979) Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system. Biochem. Biophys. Res. Commun. 91, 1218-1224.
11. Creba, J. A., Downes, C. P., Hawkins, P. T., Brewster, G., Michell, R. H., and Kirk, C. J. (1983) Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca21-mobilizing hormones. Biochem. J. 212, 733-747.
12. Newton, A. C. (2004) Diacylglycerol's affair with protein kinase C turns 25. Trends Pharmacol. Sci. 25, 175-177.
13. Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., and Nishizuka, Y. (1982) Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem. 257, 7847-7851.
14. Sossin, W. S. (2007) Isoform specificity of protein kinase Cs in synaptic plasticity. Learn. Mem. 14, 236-246.
15. Cameron, A. J., De Rycker, M., Calleja, V., Alcor, D., Kjaer, S., Kostelecky, B., Saurin, A., Faisal, A., Laguerre, M., Hemmings, B. A., McDonald, N., Larijani, B. and Parker, P. J. (2007) Protein kinases, from B to C. Biochem. Soc. Trans. 35, 1013-1017.
16. Jacinto, E. and Lorberg, A. (2008) TOR regulation of AGC kinases in yeast and mammals. Biochem. J. 410, 19-37.
17. Neri, L. M., Martelli, A. M., Borgatti, P., Colamussi, M. L., Marchisio, M., and Capitani, S. (1999) Increase in nuclear phosphatidylinositol 3-kinase activity and phosphatidylinositol (3,4,5) trisphosphate synthesis precede PKC-zeta translocation to the nucleus of NGF-treated PC12 cells. Faseb J. 13, 2299-2310.
18. Suzuki, A., Akimoto, K. and Ohno, S. (2003) Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms. J. Biochem. 133, 9-16.
19. Drin, G. and Scarlata, S. (2007) Stimulation of phospholipase Cbeta by membrane interactions, interdomain movement, and G protein binding-how many ways can you activate an enzyme? Cell. Signal. 19, 1383-1392.
20. Rhee, S. G. (2001) Regulation of phosphoinositide-specific phospholipase C. Annu. Rev. Biochem. 70, 281-312.
21. Merida, I., Avila-Flores, A., and Merino, E. (2008) Diacylglycerol kinases: at the hub of cell signalling. Biochem. J. 409, 1-18.
22. Sakai, N., Sasaki, K., Ikegaki, N., Shirai, Y., Ono, Y., and Saito, N. (1997) Direct visualization of the translocation of the gamma-subspecies of protein kinase C in living cells using fusion proteins with green fluorescent protein. J. Cell. Biol. 139, 1465-1476.
23. Violin, J. D., Zhang, J., Tsien, R. Y., and Newton, A. C. (2003) A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J. Cell. Biol. 161, 899-909.
24. Violin, J. D. and Newton, A. C. (2003) Pathway illuminated: visualizing protein kinase C signaling. IUBMB Life 55, 653-660.
25. Gallegos, L. L., Kunkel, M. T., and Newton, A. C. (2006) Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling. J. Biol. Chem. 281, 30947-30956.
26. Giorgione, J. R., Lin, J. H., McCammon, J. A., and Newton, A. C. (2006) Increased membrane affinity of the C1 domain of protein kinase Cdelta compensates for the lack of involvement of its C2 domain in membrane recruitment. J. Biol. Chem. 281, 1660-1669.
27. Newton, A. C. (2001) Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem. Rev. 101, 2353-2364.
28. Lenz, J. C., Reusch, H. P., Albrecht, N., Schultz, G., and Schaefer, M. (2002) Ca21-controlled competitive diacylglycerol binding of protein kinase C isoenzymes in living cells. J. Cell. Biol. 159, 291-302.
29. Kohout, S. C., Corbalan-Garcia, S., Torrecillas, A., Gomez-Fernandez, J. C., and Falke, J. J. (2002) C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound state. Biochemistry 41, 11411-11424.
30. Keranen, L. M. and Newton, A. C. (1997) Ca2+ differentially regulates conventional protein kinase Cs' membrane interaction and activation. J. Biol. Chem. 272, 25959-25967.
31. Guerrero-Valero, M., Marin-Vicente, C., Gomez-Fernandez, J. C., and Corbalan-Garcia, S. (2007) The C2 domains of classical PKCs are specific PtdIns(4,5)P2-sensing domains with different affinities for membrane binding. J. Mol. Biol. 371, 608-621.
32. Corbalan-Garcia, S., Garcia-Garcia, J., Rodriguez-Alfaro, J. A., and Gomez-Fernandez, J. C. (2003) A new phosphatidylinositol 4,5-bisphosphate- binding site located in the C2 domain of protein kinase Calpha. J. Biol. Chem. 278, 4972-4980.
33. Evans, J. H., Murray, D., Leslie, C. C., and Falke, J. J. (2006) Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain. Mol. Biol. Cell. 17, 56-66.
34. Marin-Vicente, C., Nicolas, F. E., Gomez-Fernandez, J. C., and Corbalan-Garcia, S. (2008) The PtdIns(4,5)P2 ligand itself influences the localization of PKCalpha in the plasma membrane of intact living cells. J. Mol. Biol. 377, 1038-1052.
35. Johnson, J. E., Giorgione, J., and Newton, A. C. (2000) The C1 and C2 domains of protein kinase C are independent membrane targeting modules, with specificity for phosphatidylserine conferred by the C1 domain. Biochemistry 39, 11360-11369.
36. Stahelin, R. V., Wang, J., Blatner, N. R., Rafter, J. D., Murray, D., and Cho, W. (2005) The origin of C1A-C2 interdomain interactions in protein kinase Calpha. J. Biol. Chem. 280, 36452-36463.
37. Schechtman, D. and Mochly-Rosen, D. (2001) Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene 20, 6339-6347.
38. Benes, C. H., Wu, N., Elia, A. E., Dharia, T., Cantley, L. C., and Soltoff, S. P. (2005) The C2 domain of PKCdelta is a phosphotyrosine binding domain. Cell 121, 271-280.
39. Staudinger, J., Lu, J., and Olson, E. N. (1997) Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha. J. Biol. Chem. 272, 32019-32024.
40. Adamski, F. M., Zhu, M. Y., Bahiraei, F., and Shieh, B. H. (1998) Interaction of eye protein kinase C and INAD in Drosophila. Localization of binding domains and electrophysiological characterization of a loss of association in transgenic flies. J. Biol. Chem. 273, 17713-17719.
41. Leitges, M., Kovac, J., Plomann, M., and Linden, D. J. (2004) A unique PDZ ligand in PKCalpha confers induction of cerebellar long-term synaptic depression. Neuron 44, 585-594.
42. Stiffler, M. A., Chen, J. R., Grantcharova, V. P., Lei, Y., Fuchs, D., Allen, J. E., Zaslavskaia, L. A., and MacBeath, G. (2007) PDZ domain binding selectivity is optimized across the mouse proteome. Science 317, 364-369.
43. Hall, C., Lim, L., and Leung, T. (2005) C1, see them all. Trends Biochem. Sci. 30, 169-171.
44. Oancea, E. and Meyer, T. (1998) Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals. Cell 95, 307-318.
45. Stensman, H. and Larsson, C. (2007) Identification of acidic amino acid residues in the protein kinase C alpha V5 domain that contribute to its insensitivity to diacylglycerol. J. Biol. Chem. 282, 28627-28638.
46. Slater, S. J., Seiz, J. L., Cook, A. C., Buzas, C. J., Malinowski, S. A., Kershner, J. L., Stagliano, B. A., and Stubbs, C. D. (2002) Regulation of PKC alpha activity by C1-C2 domain interactions. J. Biol. Chem. 277, 15277-15285.
47. Stahelin, R. V., Digman, M. A., Medkova, M., Ananthanarayanan, B., Melowic, H. R., Rafter, J. D., and Cho, W. (2005) Diacylglycerolinduced membrane targeting and activation of protein kinase Cepsilon: mechanistic differences between protein kinases Cdelta and Cepsilon. J. Biol. Chem. 280, 19784-19793.
48. Pepio, A. M. and Sossin, W. S. (1998) The C2 domain of the Ca(21)-independent protein kinase C Apl II inhibits phorbol ester binding to the C1 domain in a phosphatidic acid-sensitive manner. Biochemistry 37, 1256-1263.
49. Jose Lopez-Andreo, M., Gomez-Fernandez, J. C., and Corbalan-Garcia, S. (2003) The simultaneous production of phosphatidic acid and diacylglycerol is essential for the translocation of protein kinase Cepsilon to the plasma membrane in RBL-2H3 cells. Mol. Biol. Cell. 14, 4885-4895.
50. Farah, C. A., Nagakura, I., Weatherill, D., Fan, X., and Sossin, W. S. (2008) A physiological role for phosphatidic acid in the translocation of the novel protein kinase C Apl Ii in aplysia neurons. Mol. Cell. Biol. 28, 4719-4733.
51. Toker, A. (2005) The biology and biochemistry of diacylglycerol signalling. Meeting on molecular advances in diacylglycerol signalling. EMBO Rep. 6, 310-314.