Membrane docking geometry and target lipid stoichiometry of membrane-bound PKCα C2 domain: A combined molecular dynamics and experimental study

Journal of Molecular Biology

Volumn 402, Issue 2, 2010, Pages 301-310

  Lai, Chun Liang ^a   Landgraf, Kyle E ^b   Voth, Gregory A ^a   Falke, Joseph J ^b  

^a Dept of Medicine   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Conserved membrane targeting domain; Molecular dynamics; Phosphatidylinositol 4,5 bisphosphate regulation; Positive cooperativity; Protein kinase C activation

Indexed keywords

CALCIUM ION; LIPID; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHATIDYLSERINE; PROTEIN KINASE C ALPHA; CALCIUM; DIVALENT CATION; MEMBRANE LIPID; PROTEIN BINDING;

ARTICLE; ATOM; CELL MEMBRANE; CONCENTRATION (PARAMETERS); ELECTRIC POTENTIAL; ELECTRON SPIN RESONANCE; EXPERIMENT; EXPERIMENTAL STUDY; GEOMETRY; LIPID BILAYER; MEMBRANE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; SIMULATION; STOICHIOMETRY; CHEMICAL MODEL; CHEMICAL STRUCTURE; METABOLISM;

CALCIUM; CATIONS, DIVALENT; ELECTRON SPIN RESONANCE SPECTROSCOPY; MEMBRANE LIPIDS; MEMBRANE PROTEINS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLSERINES; PROTEIN BINDING; PROTEIN KINASE C-ALPHA;

EID: 77956789005     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.07.037     Document Type: Article

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