Phosphorylation of APP695 at Thr668 decreases γ-cleavage and extracellular Aβ

Biochemical and Biophysical Research Communications

Volumn 357, Issue 4, 2007, Pages 1004-1010

  Feyt, Christine ^a   Pierrot, Nathalie ^a   Tasiaux, Bernadette ^a   Van Hees, Joanne ^a   Kienlen Campard, Pascal ^a   Courtoy, Pierre J ^a   Octave, Jean Noël ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Secretase; A ; Alzheimer's disease; APP; Phosphorylation

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID PRECURSOR PROTEIN;

ANIMAL CELL; ARTICLE; BRAIN CELL; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CHO CELL; CONTROLLED STUDY; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SITE DIRECTED MUTAGENESIS;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BINDING SITES; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; EXTRACELLULAR FLUID; MUTAGENESIS, SITE-DIRECTED; NEURONS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN BINDING; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; THREONINE;

RATTUS;

EID: 34247858992     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.04.036     Document Type: Article

References (19)

1. Braak H., and Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berl.) 82 (1991) 239-259
2. Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., and Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl. Acad. Sci. USA 82 (1985) 4245-4249
3. Kang J., Lemaire H.G., Unterbeck A., Salbaum J.M., Masters C.L., Grzeschik K.H., Multhaup G., Beyreuther K., and Muller-Hill B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325 (1987) 733-736
4. Octave J.N. The amyloid peptide and its precursor in Alzheimer's disease. Rev. Neurosci. 6 (1995) 287-316
5. Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., Teplow D.B., Ross S., Amarante P., Loeloff R., Luo Y., Fisher S., Fuller J., Edenson S., Lile J., Jarosinski M.A., Biere A.L., Curran E., Burgess T., Louis J.C., Collins F., Treanor J., Rogers G., and Citron M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE [see comments]. Science 286 (1999) 735-741
6. Iijima K., Ando K., Takeda S., Satoh Y., Seki T., Itohara S., Greengard P., Kirino Y., Nairn A.C., and Suzuki T. Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5. J. Neurochem. 75 (2000) 1085-1091
7. Oishi M., Nairn A.C., Czernik A.J., Lim G.S., Isohara T., Gandy S.E., Greengard P., and Suzuki T. The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells. Mol. Med. 3 (1997) 111-123
8. Lee M.S., Kao S.C., Lemere C.A., Xia W.M., Tseng H.C., Zhou Y., Neve R., Ahlijanian M.K., and Tsai L.H. APP processing is regulated by cytoplasmic phosphorylation. J. Cell Biol. 163 (2003) 83-95
9. Ando K., Iijima K.I., Elliott J.I., Kirino Y., and Suzuki T. Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid. J. Biol. Chem. 276 (2001) 40353-40361
10. Lemarchand P., Jaffe H.A., Danel C., Cid M.C., Kleinman H.K., Stratford-Perricaudet L.D., Perricaudet M., Pavirani A., Lecocq J.P., and Crystal R.G. Adenovirus-mediated transfer of a recombinant human alpha 1-antitrypsin cDNA to human endothelial cells. Proc. Natl. Acad. Sci. USA 89 (1992) 6482-6486
11. Stratford-Perricaudet L.D., Makeh I., Perricaudet M., and Briand P. Widespread long-term gene transfer to mouse skeletal muscles and heart. J. Clin. Invest. 90 (1992) 626-630
12. Essalmani R., Macq A.F., Mercken L., and Octave J.N. Missense mutations associated with familial Alzheimer's disease in Sweden lead to the production of the amyloid peptide without internalization of its precursor. Biochem. Biophys. Res. Commun. 218 (1996) 89-96
13. Macq A.F., Czech C., Essalmani R., Brion J.P., Maron A., Mercken L., Pradier L., and Octave J.N. The long term adenoviral expression of the human amyloid precursor protein shows different secretase activities in rat cortical neurons and astrocytes. J. Biol. Chem. 273 (1998) 28931-28936
14. Feyt C., Kienlen-Campard P., Leroy K., N'kuli F., Courtoy P.J., Brion J.P., and Octave J.N. Lithium chloride increases the production of amyloid beta peptide independently from its inhibition of GSK3. J. Biol. Chem. (2005)
15. Vingtdeux V., Hamdane M., Gompel M., Begard S., Drobecq H., Ghestem A., Grosjean M.E., Kostanjevecki V., Grognet P., Vanmechelen E., Buee L., Delacourte A., and Sergeant N. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism. Neurobiol. Dis. 20 (2005) 625-637
16. Liu F., Su Y., Li B.L., Zhou Y., Ryder J., Gonzalez-DeWhitt P., May P.C., and Ni B.H. Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35.Cdk5 and p25/Cdk5. FEBS Lett. 547 (2003) 193-196
17. Ryder J., Su Y., Liu F., Li B., Zhou Y., and Ni B. Divergent roles of GSK3 and CDK5 in APP processing. Biochem. Biophys. Res. Commun. 312 (2003) 922-929
18. Citron M., Teplow D.B., and Selkoe D.J. Generation of amyloid beta protein from its precursor is sequence specific. Neuron 14 (1995) 661-670
19. Sano Y., Nakaya T., Pedrini S., Takeda S., Iijima-Ando K., Iijima K., Mathews P.M., Itohara S., Gandy S., and Suzuki T. Physiological mouse brain abeta levels are not related to the phosphorylation state of Threonine-668 of Alzheimer's APP. PLoS 1 (2006) e51