TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy

Nucleic Acids Research

Volumn 42, Issue 5, 2014, Pages 3089-3103

  Alagoz, Meryem ^a,b   Wells, Owen S ^b   El Khamisy, Sherif F ^a,b,c  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF SUSSEX   (United Kingdom)

^c ZEWAIL CITY OF SCIENCE AND TECHNOLOGY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

APURINIC OR APYRIMIDINIC ENDONUCLEASE I; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA TOPOISOMERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHODIESTERASE; TEMOZOLOMIDE; TYROSYL DNA PHOSPHODIESTERASE 1; UNCLASSIFIED DRUG;

ARTICLE; CANCER GENE THERAPY; CANCER RESISTANCE; CLONOGENIC ASSAY; CONTROLLED STUDY; DNA ALKYLATION; DNA DAMAGE; DNA STRAND BREAKAGE; DNA STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; GENOTOXICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; SENSITIZATION;

ALKYLATING AGENTS; CELL LINE; CELL LINE, TUMOR; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; HUMANS; NEOPLASMS; PHOSPHORIC DIESTER HYDROLASES; POLY(ADP-RIBOSE) POLYMERASES; TRANSCRIPTION, GENETIC;

EID: 84898947618     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt1260     Document Type: Article

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