ATM Deficiency Results in Accumulation of DNA-Topoisomerase I Covalent Intermediates in Neural Cells

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Alagoz, Meryem ^a   Chiang, Shih Chieh ^a   Sharma, Abhishek ^a   El Khamisy, Sherif F ^a,b,c  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b Ain Shams University   (Egypt)

^c Technology and Innovation   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; ATM PROTEIN; CAMPTOTHECIN; CULLIN; DNA TOPOISOMERASE; PHOSPHATIDYLINOSITOL 3 KINASE; REACTIVE OXYGEN METABOLITE; TELOMERIC REPEAT BINDING FACTOR 1; 2-MORPHOLIN-4-YL-6-THIANTHREN-1-YL-PYRAN-4-ONE; ATM PROTEIN, HUMAN; DNA TOPOISOMERASE INHIBITOR; ENZYME INHIBITOR; MORPHOLINE DERIVATIVE; PHOSPHODIESTERASE; PYRONE DERIVATIVE; TDP1 PROTEIN, HUMAN; TOP1 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; ATAXIA; ATAXIA TELANGIECTASIA; COMET ASSAY; COMPLEX FORMATION; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; EMBRYO; HUMAN; HUMAN CELL; MOUSE; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PROTEIN CLEAVAGE; PROTEIN DEFICIENCY; PROTEIN DEGRADATION; SINGLE STRANDED DNA BREAK; SUMOYLATION; ANTAGONISTS AND INHIBITORS; ASTROCYTE; BIOASSAY; CELL LINE; DEFICIENCY; DRUG EFFECTS; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ATAXIA TELANGIECTASIA;

ASTROCYTES; ATAXIA TELANGIECTASIA MUTATED PROTEINS; BIOLOGICAL ASSAY; CAMPTOTHECIN; CELL LINE; DNA BREAKS, SINGLE-STRANDED; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; MORPHOLINES; OXIDATIVE STRESS; PHOSPHORIC DIESTER HYDROLASES; PYRONES; SIGNAL TRANSDUCTION; TOPOISOMERASE I INHIBITORS; TRANSCRIPTION, GENETIC;

EID: 84876549669     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058239     Document Type: Article

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